枯草芽孢杆菌JS01对肥胖小鼠肠道菌群及脂褐质的影响

探究枯草芽孢杆菌JS01对高脂饮食引起的肠道菌群紊乱、肥胖、肝脏脂质沉积及过氧化等是否有积极的治疗作用。以雄性小鼠为实验动物建立肥胖模型组(C～F)，并用不同含量的枯草芽孢杆菌JS01饲喂低、中、高干预组(D、E、F)。结果表明：添加枯草芽孢杆菌后，干预组F的体质量显著减轻，干预组E、F的体质量增长率明显降低。高脂饮食使模型对照组C小肠中双歧杆菌含量上升、乳酸杆菌含量下降、肝脏脂肪变性明显且脂褐质含量上升，添菌后使模型干预组(D、E、F)小肠中的大肠杆菌和双歧杆菌含量均下降、乳酸杆菌含量上升、肝脏脂肪变性程度减轻且脂褐质含量降低。枯草芽孢杆菌JS01能改善因高脂饮食引起的肥胖、肠道菌群紊乱、肝脏脂质沉积及过氧化。

Effect of Bacillus subtilis JS01 Ingestion on Intestinal Flora and Lipofuscin in Obese Mice

This study was undertaken to observe whether or not Bacillus subtilis JS01 ingestion has a positive therapeutic effect on high-fat diet caused intestinal flora disorder, obesity, lipid peroxidation and fat deposition in mice. Male mice were used to create experimental obesity model groups (C through F) and different doses of Bacillus subtilis JS01 were fed to low-, middle- and high-dose intervention groups (D, E and F), respectively. The results showed that Bacillus subtilis JS01 supplementation resulted in a significant reduction in the body weight of intervention group F and in the weight gain of intervention groups E and F. High-fat diet model group C showed an increase in intestinal Bifidobacteria level, a decrease in intestinal Lactobacillus level, remarkable hepatic steatosis, and a rise in hepatic lipofuscin. Oral administration of Bacillus subtilis JS01 could decrease intestinal Bifidobacteria and Lactobacillus levels, relieve hepatic steatosis and reduce hepatic lipofuscin. In conclusion, Bacillus subtilis JS01 can improve high-fat diet caused obesity, intestinal flora disorder, lipid peroxidation and fat deposition in mice.