| 乳清多肽对D-半乳糖衰老模型大鼠血清和脏器组织抗氧化效果的影响 |
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| 引用本文： | 彭新颜,孔保华,熊幼翎.乳清多肽对D-半乳糖衰老模型大鼠血清和脏器组织抗氧化效果的影响[J].食品科学,2010,31(9):238. |
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| 作者姓名： | 彭新颜 孔保华 熊幼翎 |
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| 作者单位： | 鲁东大学食品工程学院;东北农业大学食品学院;肯塔基大学动物与食品科学系; |
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| 基金项目： | 国家“863”计划项目(2008AA10Z315) |
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| 摘 要： | 研究乳清蛋白的碱性蛋白酶水解产物对D-半乳糖(D-gal)衰老模型大鼠抗氧化效果的影响。将大鼠分为7组,包括正常对照组、D-gal模型阴性对照组、D-gal+未水解乳清蛋白组、D-gal+乳清蛋白肽低剂量组、D-gal+乳清蛋白肽中剂量组、D-gal+乳清蛋白肽高剂量组和D-gal+抗坏血酸模型阳性对照组。各处理组灌胃45d后,检测衰老大鼠血清、心脏和肾脏的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和丙二醛(MDA)含量的变化及肝脏中过氧化氢酶(CAT)活性的变化。抗坏血酸阳性对照组和低、中、高剂量乳清多肽组均可使大鼠血清、心脏和肾脏的SOD、GSH-Px及CAT活性提高,MDA含量降低,并且与阴性对照组相比差异显著(P<0.05)。其中,高剂量乳清多肽组(200mg/kgbw)对SOD酶活性作用最显著,使血清SOD活性比阴性对照组提高了29.2%。高剂量乳清多肽组使肾脏GSH-Px活性及肝脏中CAT活性达到了阳性对照抗坏血酸的水平(P>0.05),同时,中剂量乳清多肽组(100mg/kgbw)使心脏中的MDA含量与阴性对照组相比下降了38.6%。结果表明,乳清多肽能够通过提高生物体内抗...
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| 关 键 词： | D-半乳糖 大鼠 乳清蛋白水解物 抗氧化能力 |
Antioxidative Effect of Whey Protein Hydrolysates in Serum,Heart and Kidney of D-galactose-induced Aging Rats |
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| PENG Xin-yan,KONG Bao-hua,XIONG You-ling.Antioxidative Effect of Whey Protein Hydrolysates in Serum,Heart and Kidney of D-galactose-induced Aging Rats[J].Food Science,2010,31(9):238. |
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| Authors: | PENG Xin-yan KONG Bao-hua XIONG You-ling |
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| Affiliation: | PENG Xin-yan1,2,KONG Bao-hua2,*,XIONG You-ling3(1.College of Food Engineering,Ludong University,Yantai 264025,China,2.College of Food Science,Northeast Agricultural University,Harbin 150030,3.Department of Animal , Food Sciences,University of Kentucky,Lexington 40546,USA) |
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| Abstract: | The antioxidative effect of whey protein isolate(WPI) hydrolysates on aging rats induced by D-galactose(D-gal) was investigated.The rats were divided into seven groups including the control group,D-gal model group,D-gal-induced rats treated with unhydrolyzed WPI,D-gal-induced rats treated with WPI hydrolysates at low,middle and high dosages,and D-gal-induced rats treated with ascorbic acid as the positive group.The experiment period was last for 45 days.The effect of WPI hydrolysates on antioxidative enzyme... |
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| Keywords: | D-galactose rats whey protein hydrolysate antioxidant capacity |
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