Co-immobilization of chitosan and dermatan sulfate from Raja montagui skin on polyethylene terephthalate surfaces: Characterization and antibiofilm activity |
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| Authors: | Jihane Hayder Mohamed Aymen Chaouch Noumi Amira Mohamed Ben Mansour Frédéric Chaubet |
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| Affiliation: | 1. University of Monastir, Laboratory of Genetics, Biodiversity and Bioresources Valorization (LR11ES41), High Institute of Biotechnology of Monastir, Monastir, Tunisia;2. University of Monastir, Laboratory of interfaces and advanced materials (LIMA), Faculty of Sciences of Monastir, Monastir, Tunisia;3. University of Monastir, Laboratory of Contagious Diseases and Biologically Active Substances (LR99ES27), Faculty of Pharmacy, Monastir, Tunisia;4. Galilee Institute, University of Paris 13, Paris-Sorbonne University, Laboratory for Vascular Translational Science, Villetaneuse, France |
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| Abstract: | In this work, polyethylene terephthalate (PET) was chemically modified by covalent co-immobilization of two separate layers of bioactive polymers composed of chitosan and a new dermatan sulfate isolated from Raja montagui skin. The new materials obtained were characterized by determination of carboxyl groups, ATR-FTIR spectroscopy, drop water contact angle, SEM, and TGA measurements. The different immobilizations modified the surface characteristics; especially when the first layer was dermatan sulfate (PET–DS–Chito) which presented the best surface wettability (71?±?3°). It also reduced the ability of Staphylococcus epidermidis to form biofilm on PET surfaces which could decrease the virulence of vascular prosthesis infections. |
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| Keywords: | Antibiofilm chitosan dermatan sulfate material polyethylene terephthalate Staphylococcus epidermidis surface modification |
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