一种微流控2×2光开关的性能研究

微流控光学是在微尺度上通过操控微流体达到调节系统光学特性的技术。微流控光开关在多个元件集成到单一微流控芯片并实现可重构的微流控光路中起重要作用。使用气动方式设计了一种光路可重构的2×2光开关。通过压缩气体驱动控制一个可调气隙反射镜的状态,使光在微流道内交替发生透射和全反射,实现光开关功能。通过在COMSOL软件中仿真分析,得出其消光比为10.2dB、开关周期可达到60ms。结果显示,该方法具有较好的开关性能。此开关可与其他器件集成,制作复杂的微流控器件以实现其他不同的功能。     

微流控拉曼检测芯片的制备与应用

微流控芯片系统具有高效率、低损耗、高安全系数、高灵敏度等优势,表面增强拉曼散射(SERS)光谱具有灵敏度高以及指纹效应强等优点。从两方面对微流控拉曼检测芯片进行综述:微流控芯片通道和SERS基底的制备以及微流控拉曼检测芯片的集成与应用。最后讨论了SERS微流控芯片在便携化应用方面的挑战和机遇,并对整个领域的未来发展方向与前景进行了展望。     

基于微流控技术的新型光衰减器器件设计

采用液体作为光学器件元素,以微流控技术、电磁驱动技术及MOEMS技术相结合,提出一种新颖的可调光衰减器结构.通过电磁驱动装置控制衰减器中微流体的位置,实现光能量的可调衰减.以电磁驱动方式控制衰减器的调节,它的工作电压小、驱动行程大,且控制电路较为简单.该衰减器具有体积小、衰减范围大的特点,有利于光衰减器的集成化、微型化及制作.     

高速光流控成像研究进展（特邀）

高速光流控成像是融合了高速光学成像和微流控的新兴交叉技术,能够对高速复杂流体环境中的生物体进行高分辨率、高通量和多信息维度的成像和定量检测分析,在生物能源、食品科学、药物筛选、疾病诊断等领域展现出卓越的应用前景。对高速光流控成像的基本原理、关键技术和前沿进展进行综述,并对该技术未来的发展趋势和面临的挑战进行展望。     

微流光纤传感器：从功能集成到功能设计（特邀）

随着微流控技术的日趋成熟,将微流控芯片技术和光微流方法在微结构光纤中进行交叉融合,已经逐渐形成了一个新的发展方向。简要综述了这一技术是如何从初期的利用微结构光纤的特殊结构,进行简单的功能集成,拓展到如今基于特殊需求进行光纤的功能设计的新阶段,以实现在微结构光纤内部构造微流控感测系统的目的。该方向的发展,不仅促进了光波导与微流物质检测技术相结合,还为实现不同检测原理在微结构光纤内的高灵敏度光纤微流传感器技术开辟了新方法与新途径。     

基于微流控芯片的生物传感器发展现状与展望

微流控芯片具有样品体积小、检测成本低、检测时间短等优点,与光学传感器、电化学传感器和微波传感器结合可以构建灵敏度高、可重复、便携的检测系统。对微流控芯片在生物传感器中的最新应用进行了综述,并介绍了各种生物传感器的特性和原理,通过生物传感器和微流控芯片集成实现了对复杂生物指标的快速和高灵敏度检测。对未来的发展方向进行了展望,并提出了新一代生物微流控传感器发展中存在的挑战和应对问题的策略。     

一种新型分析芯片的发展及其应用

指出微全分析系统已成为国际关注的焦点,它正向着微型化、集成化、便携化、自动化方向发展。它使许多不连续的分析过程连续化和自动化,完成实时及在位分析,实现高效率、快速度、少耗样、低成本、无污染、大批量生产的目标。目前,微流控芯片主要应用于医学临床诊断、新型药物的研制与开发以及环境监测等领域。着重介绍了微流控分析芯片的特点、工作原理及其分类,最后强调了微流控分析芯片的发展和应用。     

微流控光脉冲调制器

为了解决常见光调制器偏振依赖或结构复杂的问题,本文基于微流控光学提出一种可控光脉冲调制器。利用基于T形结产生的离散液滴和全反射原理的微流控光开关,将连续光变换成数字脉冲信号,并通过调节液滴的长度和生成速率调制光脉冲的宽度和频率。所提微流控光脉冲调制器具有结构简单、插入损耗低、消光比高、易集成的优点。微流控光脉冲调制器的流场与光场特性被分析,结构被优化。研究结果显示：该光脉冲调制器的消光比为17.74 dB,插入损耗为0.49 dB。     

PDMS微流控芯片中的微通道加工技术

传统加工方法制作PDMS微流控芯片中的微通道存在诸多限制,特别是难以实现复杂三维微通道的加工。首先介绍了微通道的传统加工方法,接着简要介绍了不同3D打印技术的基本原理,最后重点阐述了3D打印技术在PDMS微流控芯片微通道加工中的应用。未来,微流控芯片中微通道的加工将会向着高通量、低成本、高精度、三维化、集成化、微型化的方向发展。3D打印、以纳米压印为主要代表的微纳制造技术与传统微通道成型技术的不断融合,为研究人员提供了更多的思路,必将成为微通道加工中的重要技术手段,推动微流控芯片在生物医学、检验检疫、分析化学等领域更广泛的应用。     

基于微流控技术新型光开关器件设计

首先介绍了较为常用的几种光开关的工作原理、特点和应用。描述了MEMS、MOEMS、微流控技术。以MOEMS及微流控技术相接合,提出一种新的微流控光开关阵列结构,通过电控方法改变微流控芯片波导结构,实现光路变化。该光开关具有体积小,结构简单,功率损耗低,有利于光开关阵列集成化、微型化及制作。以电控方式控制光开关,在开关速度上比温控更快、更稳定,且控制电路简单等特点易构成大容量交换矩阵。     

Hybrid Integration of an Active Pixel Sensor and Microfluidics for Cytometry on a Chip

Reported are motivations and approaches for the integration of custom sensors with microfluidic devices for cytometry on a chip and related fluid metering applications. To demonstrate, details of a digital 16-element mixed-signal CMOS active pixel optical sensor with adaptive spatial filtering is first described. The 0.18-mum CMOS fabricated sensor is then shown coupled to a microfluidic channel via a polymer encapsulated chip-on-board approach as well as a preferred flip-chip-on-glass hybrid integration approach. However, both approaches discussed possess attributes that are well suited for reliable high-volume production. Utilizing these two disparate assembly topologies, the intelligent sensor's general behavior, optical input dynamic range, and near-field sensitivity to polymer beads being transported in a microfluidic channel is explored. The findings suggest that discrete near-field sensor integration with microfluidics is a well-positioned integration approach for helping to obviate the need for precision analog-to-digital conversion, optical fiber microchannel coupling, and conventional microscopy for a set of relevant micro total analysis system applications. By opting instead for a hybrid multichip module approach to system integration, this study marks a slight departure in strategy relative to many common monolithic system-on-chip integration efforts     

Light Actuation of Liquid in Optofluidics

Optofluidics is the integration of optics and microfluidics（so-called lab on the chip）. Wherein the actuation of liquid is a key technic. In a variety of methods for controlling microscale liquid, the light actuation is particularly interesting. The light actuation offers a novel way to control the flow of fluids for biomedical and biotechnological applications, etc.. The complexity and cost of devices sometimes may be greatly reduced by using complete optical control and may be more flexible in operation than other methods. However the light actuation of liquid is a burgeoning field as well as optofluidics. There is lots of work to do. Here we systematically describe four mechanisms for the light actuation of liquid based on the following points： optoelectrowetting, photothermal effect, radiation pressure, photosensitive substance.     

集成光学国际研究进展

介绍了集成光学基本概念及其主要应用领域,分析了集成光学国际研究现状。在理论研究方面,对新型器件的设计、计算和模拟以及基于固体物理学和波动光学的基础理论研究是目前研究热点;而在器件研究方面,通信及传感器件是目前的研究热点。同时还分析了集成光学器件的发展趋势,指出光学双稳态集成器件以及新一代集成光学传感器的研究将是未来集成光学器件的一个研究热点。     

Microfluidics for Rapid Detection of Live Pathogens

Rapid, sensitive, and selective detection of live pathogens remains a key priority for quality control and risk assessment. While conventional methods often require complicated workflows, costly reagents, lab equipment, and are time-consuming, rendering them inadequate for field testing and low-resource settings. Increased attention has been drawn to developing alternative low-cost and rapid methods to detect on-site live pathogens in different environmental matrices. Among them, microfluidic devices that integrate various laboratory functions in a miniaturized manner have proven to be a promising tool for the rapid and sensitive detection of pathogens. Herein, the development of microfluidic devices specifically designed for the detection of live pathogens is discussed along a concise summary of novel microfluidics systems recently developed, contrasted to conventional methods regarding assay time, the limit of detection, and target organisms. These include a variety of micro total analysis systems (µTAS) and microfluidic paper-based analytical devices (µPADs) in combination with molecular methods and traditional live cell detection techniques, such as cell culture, DNA intercalating dyes, resazurin, and immobilized bioreceptors (e.g., aptamers and capture antibodies). Furthermore, insights on the future perspectives of microfluidics for live pathogen detection with a highlight on the rapid and low-cost method development for field testing are provided.     

Two-Photon Polymerization Lithography for Optics and Photonics: Fundamentals,Materials, Technologies,and Applications

The rapid development of additive manufacturing has fueled a revolution in various research fields and industrial applications. Among the myriad of advanced 3D printing techniques, two-photon polymerization lithography (TPL) uniquely offers a significant advantage in nanoscale print resolution, and has been widely employed in diverse fields, for example, life sciences, materials sciences, mechanics, and microfluidics. More recently, by virtue of the optical transparency of most of the resins used, TPL is finding new applications in optics and photonics, with nanometer to millimeter feature dimensions. It enables the minimization of optical elements and systems, and exploration of light-matter interactions with new degrees of freedom, never possible before. To review the recent progress in the TPL related optical research, it starts with the fundamentals of TPL and material formulation, then discusses novel fabrication methods, and a wide range of optical applications. These applications notably include diffractive, topological, quantum, and color optics. With a panoramic view of the development, it is concluded with insights and perspectives of the future development of TPL and related potential optical applications.     

Microfluidics meets MEMS

The use of planar fluidic devices for performing small-volume chemistry was first proposed by analytical chemists, who coined the term "miniaturized total chemical analysis systems" (/spl mu/TAS) for this concept. More recently, the /spl mu/TAS field has begun to encompass other areas of chemistry and biology. To reflect this expanded scope, the broader terms "microfluidics" and "lab-on-a-chip" are now often used in addition to /spl mu/TAS. Most microfluidics researchers rely on micromachining technologies at least to some extent to produce microflow systems based on interconnected micrometer-dimensioned channels. As members of the microelectromechanical systems (MEMS) community know, however, one can do more with these techniques. It is possible to impart higher levels of functionality by making features in different materials and at different levels within a microfluidic device. Increasingly, researchers have considered how to integrate electrical or electrochemical function into chips for purposes as diverse as heating, temperature sensing, electrochemical detection, and pumping. MEMS processes applied to new materials have also resulted in new approaches for fabrication of microchannels. This review paper explores these and other developments that have emerged from the increasing interaction between the MEMS and microfluidics worlds.     

Solid state optical space switches for network cross-connect andprotection applications

Network protection and reconfiguration is becoming increasingly important in fiber optic communications systems. This is driven by the intense traffic and high cost of lost high-data-rate optical connections. Optical cross-connects at the nodes in transmission systems are developing rapidly in response. A key optical component required for these applications is an optical space switch. Since the required timescale of network reconfiguration at the optical level is on the order of 50 ms to prevent electrical intervention. The optical space switching speed must be approximately 5 ms or faster. The demand created by these applications has motivated the development of a solid state optical space switch based on a novel planar-waveguide technology. This planar integrated optics technology relies on the thermo-optic effect in specialized optical polymer materials and results in reliable optical space switches without moving parts to wear out. This article reviews the state of the art in solid state optical space switches based on thermo-optic polymers and applications of these switches in network communication systems. The same polymer-based planar waveguide technology used to make the solid state optical space switches of today provides the basis for WDM devices. Electro-optic modulators, and devices integrating several functions (space switching, wavelength multiplexing, light generation and detection) in one component in the years to come     

基于微纳器件的全光图像处理技术及应用

纳米技术的飞速发展促进了微纳结构的加工制造、科学研究及工业应用。而微纳结构的光学特性是近年来光学领域的研究热点之一,其带动了纳米光子学、表面等离激元光学、超表面/超材料光学、拓扑光子学、非厄米光学等新兴学科的发展,为实现光的高精度、全方位操控奠定了重要技术基础。文中主要针对全光图像处理中的边缘检测技术,系统地梳理了微纳光学结构和器件在实现光计算（如微分、卷积等）时涉及的基础、原理、技术和应用,并展望了其在超快图像处理、高对比度显微成像、卷积神经网络和智能光学系统等领域的应用研究。     

Recent developments in micromachined silicon

This paper provides a review, directed at scientists and engineers concerned with microsystems technology, of advances in microelectromechanical systems (MEMS). The emphasis is on silicon technology, where the electrical properties of the material are exploited in circuitry and the mechanical properties are used in sensor and microstructure applications. Developments in surface micromachining are discussed, and applications in sensors, microelectronic devices, vacuum microanalysis systems, microfluidics, and optoelectronic subsystems are reviewed. Some emerging technologies are assessed and promising new research directions are identified