Collaborative Action of Microglia and Astrocytes Mediates Neutrophil Recruitment to the CNS to Defend against Escherichia coli K1 Infection

Escherichia coli K1 is a leading cause of neonatal bacterial meningitis. Recruitment of neutrophils to the central nervous system (CNS) via local immune response plays a critical role in defense against E. coli K1 infection; however, the mechanism underlying this recruitment remains unclear. In this study, we report that microglia and astrocytes are activated in response to stimulation by E. coli K1 and/or E. coli K1-derived outer membrane vesicles (OMVs) and work collaboratively to drive neutrophil recruitment to the CNS. Microglial activation results in the release of the pro-inflammatory cytokine TNF-α, which activates astrocytes, resulting in the production of CXCL1, a chemokine critical for recruiting neutrophils. Mice lacking either microglia or TNF-α exhibit impaired production of CXCL1, impaired neutrophil recruitment, and an increased CNS bacterial burden. C-X-C chemokine receptor 2 (CXCR2)-expressing neutrophils primarily respond to CXCL1 released by astrocytes. This study provides further insights into how immune responses drive neutrophil recruitment to the brain to combat E. coli K1 infection. In addition, we show that direct recognition of E. coli K1 by microglia is prevented by the K1 capsule. This study also reveals that OMVs are sufficient to induce microglial activation.     

Strength,strain capacity and toughness of five dual-phase pipeline steels

The effect of microstructures on strength, strain capacity and low temperature toughness of a micro-alloyed pipeline steel was elucidated. Five various dual-pha...     

含大规模新能源的电力系统STATCOM选址及容量优化

为了改善含大规模新能源电力系统电压稳定性,针对大电网系统提出了一种基于分区优化的静止同步补偿器（static synchronous compensator, STATCOM）动态无功多目标选址定容方法。提出了一种基于电气距离和暂态电压特性的分区方法,能够有效地考虑电力系统拓扑结构、线路参数以及励磁系统参数和稳定器参数等对电力系统分区的影响;采用电压控制指标辨识STATCOM最优安装节点;构建了包含投资成本、静态电压稳定指标和暂态电压严重性指标的多目标动态无功规划模型;采用基于自适应协方差矩阵和混沌搜索的多目标群搜索优化算法和熵权理想度排序法对多目标无功规划模型进行求解和决策推理。对所提方法在某省级规划电网中进行了测试,仿真结果表明,优化后的STATCOM配置方案能够有效改善电力系统静态和暂态电压稳定性。     

超声马达各向异性摩擦材料性能的试验研究

根据超声马达对摩擦材料切向和纵向性能的不同要求,采用在酚醛树脂胶中添加玻璃丝布和玻璃纤维增强的方法制备出不同弹性模量匹配的各向异性摩擦材料,并对其性能进行了测试。结果表明:当摩擦材料垂直方向与水平方向的弹性模量的比值为0.71~1.42时,摩擦材料受振动头的正压力和驱动力先增大后减小,比值为1.24时,马达的正压力和驱动力最大,驱动效果最好。     

山羊皮家具革开发技术

对山羊皮家具革技术进行了研究,针对其结构特征,分别对准备工段和涂饰操作作了重要说明,得到成革质量好,实用性高的山羊皮家具革。     

钨镍共掺杂V2O5薄膜的光电特性研究

利用溶胶–凝胶旋涂法和后退火工艺在FTO导电玻璃上制备了钨镍共掺杂V₂O₅薄膜,研究了薄膜在不同温度和不同偏压下的光电特性和相变特性。利用X射线衍射仪（XRD）、扫描电子显微镜（SEM） 和X射线光电子能谱仪（XPS） 测试了钨镍共掺杂V₂O₅薄膜的晶体结构、表面形貌和组分,分析了不同钨镍共掺杂浓度对V₂O₅薄膜相变光电特性的影响。结果表明,当钨和镍的掺杂质量分数分别为3 %和1.5 %时,钨镍共掺杂的V₂O₅薄膜的相变温度为218.5 ℃,在可见光范围内有较高的透过率,在近红外1310 nm波长处的光学透过率达48.83%,与未掺杂V₂O₅薄膜的光学透过率相比提高了10.29%,薄膜电阻降低了30.53%,热致回线宽度收窄为15 ℃,说明钨镍共掺杂的V₂O₅薄膜具有良好的可逆相变光电特性,有望在新型光电器件领域得到较好的应用。     

Sogatella furcifera Saliva Mucin-like Protein Is Required for Feeding and Induces Rice Defences

The white-backed planthopper (WBPH), Sogatella furcifera, is one of the most important piercing-sucking pests of rice (Oryza sativa) in Asia. Mucin-like salivary protein (SFMLP) is highly expressed in the salivary glands of WBPH, which plays an important role in WBPH feeding. In this study, WBPH injected with dsSFMLP had difficulty in sucking phloem sap from rice plants, which significantly reduced their food intake, weight, and survival. In contrast, the knockdown of the SFMLP gene had only a marginal effect on the survival of WBPH fed an artificial diet. Further studies showed that silencing SFMLP resulted in the short and single-branched salivary sheaths secretion and less formation of salivary flanges in rice. These data suggest that SFMLP is involved in the formation of the salivary sheath and is essential for feeding in WBPH. Overexpression of the SFMLP gene in rice plants promoted the feeding of WBPH, whereas silencing the gene in rice plants significantly decreased WBPH performance. Additionally, it was found that overexpression of SFMLP in rice plants elicited the signalling pathway of SA (salicylic acid) while suppressing JA (jasmonic acid); in contrast, silencing of the SFMLP gene in rice plants showed the opposite results. This study clarified the function of SFMLP in WBPH feeding as well as mediating rice defences.     

服装材料悬垂伸长量与成衣样板修正量的研究

服装材料是成衣生产与制作的基本要素,其特性将直接影响成衣穿着的美观和舒适度,也影响成衣生产中工业样板的准确性.通过自制的模具(180°半圆模型)测量服装材料在悬垂状态下不同纱向、不同基础长度的悬垂伸长量,进行科学合理的量化分析,总结出服装材料悬垂伸长的规律.通过函数关系建立了服装材料悬垂伸长量和成衣样板修正量间的关系,为成衣样板的修正提供了科学的、可靠的依据,提高了成衣工业样板的制作效率和结构、规格的精度.     

Research on a New Hybrid System of a Tyre Crane Using Supercapacitors

Research on a hybrid system of a crane is a focus which considers environmental protection and energy saving.A new environmental protection and energy saving hybrid system of tyre crane.which utilizes supercapacitors as the energy store device,is presented.Analyzing the pdneiple of supercapacitors,the model of the crane's hybrid system is set up in this paper,and the model of main blocks are established.Through simulation analyzing,the energy saving result of the new hybrid system is obtained,and the good application value of the new hybrid system is explained.