Effects of citrate on the different phases of calcium oxalate crystallization

Urinary citrate appears to be an important factor in the crystallization process of calcium oxalate and calcium phosphate. The urinary excretion of citrate was found to be significantly lower in patients with calcium oxalate stone disease as compared with normal subjects, and about 30 per cent of the calcium stone formers can be considered as hypocitraturic. The lowest excretion of citrate was recorded in urine collected during the night. Citrate has significant effects on supersaturation with respect to both calcium oxalate and calcium phosphate, it also inhibits the growth of these crystals. In addition, citrate appears to be capable of inhibiting the aggregation of crystals composed of calcium oxalate, brushite, and hydroxyapatite. The heterogenous growth of calcium oxalate on calcium phosphate is also counteracted by citrate. As a consequence of the crucial role of citrate in these processes, stone prevention with alkaline citrate has become an attractive form of treatment in patients with recurrent stone formation. Single evening dose administration of sodium potassium citrate resulted in an of sodium potassium citrate resulted in an increased excretion of citrate, reduced levels of the calcium/citrate ratio as well as supersaturation with respect to calcium oxalate and a decreased rate of stone formation. However, conflicting results of stone preventive treatment with alkaline citrate have been reported by different groups, and long-term follow-up of patients treated in a randomized way is necessary to definitely assess the efficacy of alkaline citrate.     

Cell-mediated immunological responses in cervical and vaginal cancer patients immunized with a lipidated epitope of human papillomavirus type 16 E7

Human papillomavirus (HPV) infection has been causally associated with cervical cancer. We tested the effectiveness of an HLA-A*0201-restricted, HPV-16 E7 lipopeptide vaccine in eliciting cellular immune responses in vivo in women with refractory cervical cancer. In a nonrandomized Phase I clinical trial, 12 women expressing the HLA-A2 allele with refractory cervical or vaginal cancer were vaccinated with four E786-93 lipopeptide inoculations at 3-week intervals. HLA-A2 subtyping was also performed, and HPV typing was assessed on tumor specimens. Induction of epitope-specific CD8+ T-lymphocyte (CTL) responses was analyzed using peripheral blood leukapheresis specimens obtained before and after vaccination. CTL specificity was measured by IFN-gamma release assay using HLA-A*0201 matched target cells. Clinical responses were assessed by physical examination and radiographic images. All HLA-A*0201 patients were able to mount a cellular immune response to a control peptide. E786-93-specific CTLs were elicited in 4 of 10 evaluable HLA-A*0201 subjects before vaccination, 5 of 7 evaluable HLA-A*0201 patients after two vaccinations, and 2 of 3 evaluable HLA-A*0201 cultures after all four inoculations. Two of three evaluable patients' CTLs converted from unreactive to reactive after administration of all four inoculations. There were no clinical responses or treatment toxicities. The ability to generate specific cellular immune responses is retained in patients with advanced cervical cancer. Vaccination with a lipidated HPV peptide epitope appears capable of safely augmenting CTL reactivity. Although enhancements of cellular immune responses are needed to achieve therapeutic utility in advanced cervical cancer, this approach might prove useful in treating preinvasive disease.     

孤岛油田西区聚合物驱开发研究

孤岛油田西区注聚区1997年3月投入注聚后，高渗层得到有效封堵，吸水剖面得到明显改善。注聚期间，通过实施注聚区外围水井降水或停注、油井放大生产压差和调整注聚井注入速度等开发措施，扩大了聚合物波及体积，聚合物驱取得了明显效果。     

化肥厂合成气及重整氢真空变压吸附制取高纯度氢气

从设计、生产操作和经济效益3个方面阐述了以化肥厂合成气及重氢为原料，通过真空变压吸附（VPSA）装置制取高纯度氢的过程。工业应用结果表明，该制氢工艺是一项操作简便灵活，制氢费用较低的工艺路线。VPSA装置技术和设计上的特点能够保证大的操作弹性、高的产品氢纯度和较高的氢气回收率。在36％－51％的低限负荷下，通过适当调整吸附时间，可获得纯度99％的氢气产品，89％－92％的氢气回收率。     

HPMBP与伯胺N_(1923)对希土元素(Ⅲ)的协同萃取

本文研究了HPMBP与伯胺N_(1923)的二甲苯溶液,从盐酸介质中协同萃取希土(Ⅲ)的机理。用斜率法、恒摩尔法确定了协萃配合物的组成为:RNH_3Ln(PMBP)_4。求得关于Pr(Ⅲ)协萃反应的平衡常数及协萃配合物的生成常数分别为:logK_(12)=-1.95;logβ_(12)=3.94。实验发现,协萃系数(R)随希土元素的原子序数(Z)递变而呈现“双峰效应”。还研究了协萃配合物的IR,NMR谱。     

步进式加热炉钢坯跑偏测试

钢坯在炉内的横向跑偏和纵向跑偏位移量,是步进式加热炉设备的重要性能之一.重点介绍了鞍钢1780热连轧生产线步进式加热炉钢坯跑偏测试的应用技术.     

中条山供水工程取水首部电气设计的特点

对70m落差下大型泵站供电设计中电缆的受发热这两个难点进行了论述，并通过应用特种电缆和工程塑料解决了这些难题，使泵站的设计能够较好地满足安全、便利运行的要求，为地质条件较为复杂的情况下设计泵站提供了一个比较理想的模式。     

陆西凹陷包日温都断裂构造带岩性油藏研究

为寻找岩性油藏，应用波阻抗反演地震储层预测技术，对包日温都断裂构造带砂体展布情况进行了预测，发现并落实了2个岩性圈闭，由此认为，研究区北部是大型水下扇砂体与半深湖相暗色泥岩交汇之处，有利于形成岩性油藏，这一结论将对今后加强储层预测工作和寻找有利砂体提供借鉴。     

实施油气回收的必要性和技术方案的探讨

简要介绍油气回收技术;从环保和增加经济效益的角度,以福建炼化公司的实际情况为例提出了油气回收的方案,并对实行该方案的必要性和经济效益做了分析;希望增强炼化企业对油气回收问题的重视,达到安全生产、改善环境和节约能源的目的。