建设项目工程总承包其他费的构成与计取研究

分析目前工程总承包其他费的现状及问题,并对比研究工程总承包其他费与施工管理措施费、工程建设其他费的区别和联系,探讨工程总承包其他费的构成内容与计取规则.     

金针菇多糖对微冻大黄鱼及其鱼片品质变化的影响

为研究金针菇多糖（polysaccharide from Flammulina velutipes，FVP）对微冻大黄鱼及鱼片在贮藏期间肌原纤维蛋白性质的变化及水分分布的影响，实验分别选用0.03、0.06、0.09 g/L FVP浸渍处理大黄鱼和鱼片，以无菌水处理为对照组，分析微冻贮藏期间样品的感官指标得分、总挥发性盐基氮含量、总巯基含量、Ca2＋-ATPase活性、蛋白流变学性质以及水分迁移变化规律。结果表明：FVP可有效抑制整鱼总挥发性盐基氮含量上升和感官得分的下降；减缓整鱼及鱼片在微冻过程中总巯基含量、Ca2＋-ATPase活性下降和水分流失；此外FVP还能够延缓大黄鱼因腐败而出现的蛋白凝胶能力减弱。在本实验选取的多糖浓度范围内，0.09 g/L FVP处理组保鲜效果较强。该研究结果可为FVP用于水产品贮运保鲜提供理论参考。     

The effect of alkali metal oxide on the properties of borosilicate fireproof glass: Structure,thermal properties,viscosity, chemical stability

The purpose of the current work was to research the effect of alkali metal oxide on the structure, thermal properties, viscosity and chemical stability in the glass system (R₂O–CaO–B₂O₃–SiO₂) systematically. Because the glass would emulsify when Li₂O was added to the glass batch, this article did not discuss Li₂O. The results showed that when the amount of Na₂O was less than 4 mol.%, there was a higher interconnectivity of borate and silicate sub-networks in glass, as more mixed Si–O–B bonds were present in glass. The glass samples exhibited excellent thermal properties and chemical stabilities. As the amount of Na₂O exceeded 4 mol.%, the interconnectivity of borate and silicate sub-networks was weakened. The thermal properties and chemical stabilities of the glass samples were reduced. The connectivity of the silicate sub-network was weakened slightly as the Na/K ratio varied, and the coefficient of thermal expansion (CTE) of the glass samples gradually increased, and the resistance to thermal shock (RTS) value gradually decreased. Moreover, the viscosity of the glass samples decreased with the ratio of Na/Si and Na/K increased.     

浸渍剂和压紧系数对全膜电容器端部电场分布的影响研究

全膜电容器边缘处的电场畸变是影响电容器元件击穿的重要因素之一.为研究浸渍情况和压紧系数对全膜电容器电场分布的影响,对电容器端部进行建模,通过改变浸渍情况和压紧系数,计算不同参数下电容器端部的电场分布情况,结果表明:未浸渍情况下电场最大值集中在折边处两侧,浸渍情况下场强在折边圆弧处分布较为均匀.同时发现,在浸渍情况下增大压紧系数K可以明显改善全膜电容器端部电场的分布情况.     

反坦克导弹用热电池研究进展

反坦克导弹作为击毁坦克和其他装甲目标的武器装备,在国家安全领域具有重要地位.热电池作为反坦克导弹的能源系统,对导弹功能实现具有重要意义.围绕反坦克导弹用热电池快激活和瞬时高比功率技术,结合热电池电化学材料体系发展历史、现状,探讨了提升快激活能力,提高瞬时比功率输出能力的技术,并对技术发展趋势进行了展望.     

基于整体性视角的社区更新：框架、模式与案例 — —以佛山桂华邨社区为例

现行的政府单一主导、政府与开发 商合作的社区更新模式与业主的自主更新需 求产生了矛盾。针对现有研究对社区更新的 系统性缺乏关注的问题，本文从整体视角出 发，通过构建“参与主体—程序设计—法规 政策—资金调配”四维框架，分析现行社区 更新模式与业主自主更新需求产生冲突的内 在机制。在优化现有模式的基础上，提出三 种适应业主自主更新需求的理论模式。桂华 邨业主自主更新失败的实践案例证明了本文 所提出的四维框架的重要性。最后，从政府 视角对我国社区更新机制提出优化建议。     

药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

基于网络的决策支持系统在水资源管理中的应用

综述了决策支持系统(DSS)与基于网络的决策支持系统(Web-based DSS)在水资源管理中的应用概况,通过对二者进行比较,指出Web-based DSS具有便于系统更新维护、降低用户使用门槛、扩展用户沟通渠道等优势。对Web-based DSS涉及的基础应用开发、多源信息采集与集成、多模块并行耦合、决策效果评估等关键技术进行了分析,探讨了Web-based DSS在多源异构大数据环境下面临的问题与挑战。     

AQP3 Increases Intercellular Cohesion in NSCLC A549 Cell Spheroids through Exploratory Cell Protrusions

Tumor cell aggregation is critical for cell survival following the loss of extracellular matrix attachment and dissemination. However, the underlying mechanotransduction of clustering solitary tumor cells is poorly understood, especially in non-small cell lung cancers (NSCLC). Here, we examined whether cell surface protrusions played an important role in facilitating the physical contact between floating cells detached from a substrate. We employed poly-2-hydroxyethyl methacrylate-based 3D culture methods to mimic in vivo tumor cell cluster formation. The suprastructural analysis of human NSCLC A549 cell spheroids showed that finger-like protrusions clung together via the actin cytoskeleton. Time-lapse holotomography demonstrated that the finger-like protrusions of free-floating cells in 3D culture displayed exploratory coalescence. Global gene expression analysis demonstrated that the genes in the organic hydroxyl transport were particularly enriched in the A549 cell spheroids. Particularly, the knockdown of the water channel aquaporin 3 gene (AQP3) impaired multicellular aggregate formation in 3D culture through the rearrangement of the actomyosin cytoskeleton. Moreover, the cells with reduced levels of AQP3 decreased their transmigration. Overall, these data indicate that cell detachment-upregulated AQP3 contributes to cell surface protrusions through actomyosin cytoskeleton remodeling, causing the aggressive aggregation of free-floating cells dependent on the property of the substratum and collective metastasis.