Transdermal Iontophoretic Delivery of Thyrotropin-Releasing Hormone Across Excised Rabbit Pinna Skin

Enhanced transport of a model peptide drug thyrotropin-releasing hormone (TRH), a tripeptide of molar mass 362 g and a pK_a 6.2, through excised rabbit pinna skin was achieved by means of iontophoresis with continuous current or monophase periodically pulsed current. The resulting flux in the steady state was proportional to the applied current density. In the transdermal iontophoretic delivery of TRH, the pulsed iontophoretic flux exceeded that obtained with a continuous current. At a low ionic strength, an increased degree of protonation in TRH increased the rate of permeation. The flux of TRH in a buffer at pH 4 is greater than that at pH 8 when the ionic strength is 0.1 M. At a greater ionic strength, the trend is reversed. The enhanced flux of unprotonated TRH during transdermal iontophoresis is attributed largely to electro-osmotic volume flow. An increased rate of permeation of TRH crossing the skin is achieved at low ionic strength, moderate pH, and a large duly cycle of current; the frequency of pulsed current had no significant influence on the rate of transdermal iontophoretic delivery of TRH.     

The As-prepared surfaces of C-axis-oriented Nd1Ba2Cu3Oy thin films characterized using scanning probe microscopes

Recently, superconducting Nd₁Ba₂Cu₃O_y (Ndl23) thin films with high superconducting transition temperature (T _c) have been successfully fabricated at our institute employing the standard laser ablation method. In this paper, we report the results of surface characterization of the Nd123 thin films using an ultrahigh vacuum scanning tunneling microscope/spectroscopy (UHV-STM/STS) and an atomic force microscope (AFM) system operated in air. Clear spiral pattern is observed on the surfaces of Nd123 thin films by STM and AFM, suggesting that films are formed by two-dimensional island growth mode. Contour plots of the spirals show that the step heights of the spirals are not always the integer or half-integer number of thec-axis parameter of the structure. This implies that the surface natural termination layer of the films may not be unique. This result is supported byI-V STS measurements. The surface morphology of the Nd123 thin films is compared with that of thec-axis-oriented Y₁Ba₂Cu₃S_y thin films. Surface atomic images of the as-prepared Nd123 thin films are obtained employing both STM and AFM. STS measurements show that most of the surfaces are semiconductive. The results of STS measurements together with the fact that we are able to see the surface atomic images using scanning probe microscopes suggest that exposure to air does not cause serious degradation to the as-prepared surfaces of Nd123 thin films.     

OFDM-MIMO系统及其频率同步分析

多媒体业务对无线通信的带宽与品质提出了更高的要求，OFDM和MIMO由于满足了这一需求被越来越多的无线通信标准采用所为底层的调制和传输技术。频率同步问题是OFDM—MIMO物理层设计中正确解调的前提和基础，本文介绍了OFDM—MIMO的原理、特点和频率同步问题的研究现状。     

氧化铝厂渣浆泵机械密封的失效形式及改进措施

本文介绍了渣浆泵机械密封的失效形式,并根据长期现场工作经验,分析了机械密封泄漏的主要原因,据此提出了改进措施,通过对动静环密封面倒角,改变密封面尺寸及载荷系数后有效地解决了由于径向跳动过大而引起的密封面刮碰擦裂的失效问题。     

宣钢1260 m3高炉扩容大修改造设计

宣钢l260m^3高炉大修改造时将炉容扩大到l350m^3，对高炉本体系统设备及冷却系统、自动控制及检测系统进行了全面的改造更新，在炉腹、炉腰及炉身下部高热负荷区域采用铜冷却壁，取消炉身中上部铸铁冷却壁凸台，并采用薄内衬等先进、适用、可靠、成熟的技术。     

In situ polymerization and characterization of polyester‐based polyurethane/nano‐silica composites

Polyester‐based polyurethane/nano‐silica composites were obtained via in situ polymerization and investigated by Fourier‐transform infrared spectroscopy (FTIR), or FTIR coupled with attenuated total reflectance (FTIR‐ATR), Transmission electron microscopy (TEM), atomic force microscopy (AFM), an Instron testing machine, dynamic mechanical analysis (DMA) and ultraviolet‐visible spectrophotometry (UV‐vis). FTIR analysis showed that in situ polymerization provoked some chemical reactions between polyester molecules and nano‐silica particles. FTIR‐ATR, TEM and AFM analyses showed that both surface and interface contained nano‐silica particles. Instron testing and DMA data showed that introducing nano‐silica particles into polyurethane enhanced the hardness, glass temperature and adhesion strength of polyurethane to the substrate, but also increased the resin viscosity. UV‐vis spectrophotometry showed that nano‐silica obtained by the fumed method did not shield UV radiation in polyurethane films. Copyright © 2003 Society of Chemical Industry     

Renal R2 chemoreceptor activity is attenuated after back heating in the rat

The aim of the present study was to determine the afferent connections of the nucleus accumbens in snakes, in particular its catecholaminergic input. For that purpose, in vitro and in vivo applications of retrograde tracers in the nucleus accumbens of Elaphe guttata were combined with tyrosine hydroxylase (TH) immunohistochemistry. Both techniques revealed telencephalic inputs to the nucleus accumbens originating from the diagonal band of Broca, ventral pallidum, amygdaloid complex, and dorsal cortex. Major diencephalic inputs arise from the dorsomedial thalamic nucleus and the hypothalamus. In the brainstem, a few retrogradely labeled cells were observed in the raphe nucleus and the locus coeruleus. Considerably more cells were found in the midbrain tegmentum. Within the confines of the locus coeruleus and, in particular, the midbrain tegmentum, retrogradely labeled cells stained also for TH suggesting that those areas constitute the major catecholaminergic input to the nucleus accumbens of snakes. The experimental approach used in the present study, in particular the in vitro technique, seems to be very suited for studying the development of basal ganglia organization of reptiles in the near future.     

川东地区长兴组缝洞型储层的识别

本文针对四川东部地区上二叠统长兴组(P_2~2)缝洞型储层的低孔、低渗及非均质性等特点,分析了影响这类储层识别的主要因素,提出了利用现有的地球物理测井手段定性识别储层的指标和定量综合识别储层的方法,这可望提高测试成功率。     

Synthesis, characteristics and oxygen-sensitive properties of SrMgxTi 1 − xO3 nanocrystals

SrMg_xTi_{1 - x}O₃ nanocrystals (x = 0.1–0.6) were synthesized by the stearic acid gel method. Powder samples were characterized by X-ray diffraction and X-ray photoelectron (XP) spectroscopy. The results showed that the lattice parameter a and the O 1s XP spectrum changed not only with the Mg content x but also with the grain size d of the samples. The conductivity of a thick film specimen fabricated on an aluminium oxide wafer was investigated in a nitrogen—oxygen atmosphere.     

MEASUREMENT OF THE SPECIFIC SURFACE AREA OF POWDERS BY THIN LAYER WICKING

The specific surface areas (A) of different clay mineral powders were measured by both the BET method and by thin layer wicking. The values of A for the BET and the wicking experiments coincided within a few percent. Thus, the simple and inexpensive thin layer wicking approach may well suffice to obtain reliable specific surface area values for most powders. From the wicking data it is also possible to obtain a rough estimate of the average particle size.