Comparison of Fatigue Strengths of Bulk Metallic Glasses Produced by Tilt Casting and High-Pressure Casting

High fatigue strength is one of the important factors that facilitates the industrial usage of bulk metallic glasses (BMGs). Fatigue data were analyzed using the Weibull probability models for BMGs produced with different casting processes in order to study the reliability of fatigue strengths of cast glassy alloys. The fatigue data of tilt-cast and high-pressure-cast BMGs can be explained by a three-parameter Weibull cumulative distribution function (cdf) and a mixture model of two-parameter Weibull cdfs, respectively. We conclude that the cast defects, which reduce fatigue strength, should be eliminated in order to realize a high reliability of fatigue strengths.     

Theoretical analysis of high-temperature characteristics of1.3-μm InP-based quantum-well lasers

By taking into account the electrostatic deformation in the band profiles and the temperature dependence of the optical dephasing time, we study the temperature sensitivity of the differential gain, threshold carrier density, and radiative current density in 1.3-μm InP-based strained-layer quantum-well (QW) lasers. Electrostatic deformation is analyzed by the self-consistent numerical calculation of Poisson's equation, the scalar effective-mass equation for the conduction band, and the multiband effective-mass equation for the valence band. The optical dephasing time is then obtained from the intrasubband scattering rates for electrons and holes within the fully dynamic random phase approximation including carrier-carrier and carrier-phonon interactions on an equal basis. It is clarified that the electrostatic band-profile deformation is one of the dominant mechanisms For determining the temperature sensitivity Of the differential gain, while the optical dephasing time has a pronounced influence on the transparent condition at elevated temperatures. We demonstrate that the electrostatic band-profile deformation and the temperature-dependent optical dephasing play essential roles in determining the high-temperature characteristics of InP-based QW lasers     

Experimental investigations of harmonic synchronization conditionsand mechanisms of mode-locked laser diodes induced by optical-pulseinjection

We investigated the detailed characteristics of synchronization of mode-locked laser diodes (MLLD's) by subharmonic optical pulse injection. It was shown that optical harmonic injection mode-locking was not very sensitive to injection pulse shapes. In the time domain, subharmonic injection pulses were multiplexed inside the MLLD and these multiplexed pulses effectively modulated the absorbance of the saturable absorber at the MLLD's repetition frequency. It was also found in the spectral domain that injection pulse trains should have optical spectrum components broader than the MLLD's intermode spacing, and injection spectral components should couple to at least two modes of the MLLD     

Anti-viral effect of interferon-alpha on bovine viral diarrhea virus

PURPOSE: Lamotrigine (LTG) is recognised as effective add-on therapy for focal epilepsies, but this is the first double-blind, placebo-controlled, crossover study in treatment-resistant generalised epilepsy. METHODS: The study consisted of 2 x 8-week treatment periods followed by a 4-week washout period. Patients received doses of either 75 or 150 mg daily, depending on their concomitant antiepileptic drugs (AEDs). Long-term continuation was offered at the end of the study with open-label LTG. RESULTS: Five centres in Australia recruited 26 patients who were having absence, myoclonic, or generalized tonic-clonic seizures or a combination of these. Twenty-two patients completed the study. There was a significant reduction in frequency of both tonic-clonic and absence seizure types with LTG. A 350% decrease in seizures was observed for tonic-clonic seizures in 50% of cases and for absence seizures in 33% of evaluable cases. Rash was the only adverse effect causing discontinuation. Twenty-three of 26 opted for open-label LTG, with 20 still receiving LTG for a mean of 26 months. In these 20, 80% had > or =50% seizure reduction and five (25%) were seizure free. CONCLUSIONS: This study shows that LTG is effective add-on therapy in patients with refractory generalised epilepsies. Statistically significant reduction in seizures in both absence and tonic-clonic seizure types was seen even with low doses of LTG.     

CABG after patch angioplasty of the left main coronary: artery report of a case

A 57-year-old man was admitted to our hospital because of restenosis of the left main coronary trunk (LMT) after patch angioplasty for the LMT lesion. PTCA was repeated four times during three years after patch angioplasty, but recent coronary angiogram still demonstrated 75% restenosis of the LMT lesion. Double-CABG was performed to LAD and LCX using the left internal thoracic artery and saphenous vein graft. Postoperative coronary angiogram revealed an excellent result. A careful consideration must be given to the indication of the patch angioplasty of the LMT lesion.     

Induction of tolerance to an experimental cardiac allograft through intrathymic inoculation of class II major histocompatibility complex disparate antigens

Indefinite donor-specific tolerance to a cardiac allograft can be induced through pretransplantation intrathymic injection of donor spleen cells and a single intraperitoneal injection of antilymphocyte serum. This study was designed to determine whether this phenomenon was reproducible with grafts differing in either class I major histocompatibility complex only or class II MHC only. Donors of cells and hearts in all experiments were RP rats. Class I MHC disparate grafts were performed by placing an RP heart into a Lewis recipient, and class II disparate grafts were performed with RP donors and Wistar Furth recipients. Lewis (n = 10) and Wistar Furth (n = 10) recipients underwent intraperitoneal injection of 1 ml antilympocyte serum and intrathymic injection of 5 x 10(7) RP spleen cells. Three weeks later, heterotopic cardiac transplantation was done with a heart from an RP rat. Control rats had no pretreatment or received antilympocyte serum alone. Without pretreatment, RP hearts survived 7 to 9 days (mean 8 days) in Lewis recipients (n = 5) and 9 to 14 days (mean 12 days) in Wistar Furth recipients (n = 5). Antilymphocyte serum alone produced slight prolongation of graft survival. Lewis rats pretreated with class I disparate RP splenocytes and antilympocyte serum had graft survivals of 8 to 27 days (mean 14 days), not significantly different from the results with antilympocyte serum alone. Class II disparate RP grafts placed in pretreated Wistar Furth rats had significant prolongation of graft survival, with four of five grafts surviving longer than 60 days (p < 0.01 vs antilympocyte serum alone). These results suggest that a disparity at the class II locus of the major histocompatibility complex is critical for the induction of cardiac allograft tolerance after intrathymic inoculation of allogeneic cells.     

A Two-Channel Picture Coding System: I--Real-Time Implementation

The two-channel system previously reported has been implemented in hardware using system parameters appropriate to consumer television. The basic system divides the spectrum into lowand high-frequency spatial components. The lows are coarsely sampled and finely quantized and the highs finely sampled and coarsely quantized using a companded, randomized quantizer. The purpose of this experiment was to demonstrate the potential of the system for low-cost practical application, to study the effect of the character of the randomizing noise, and to ascertain that there were no deleterious effects due to interlace, motion, or input noise. Theoretical noise calculations were qualitatively confirmed.     

Discrimination of psychoactive fungi (commonly called "magic mushrooms") based on the DNA sequence of the internal transcribed spacer region

'Magic mushrooms' (MMs) are psychoactive fungi containing the hallucinogenic compounds, psilocin (1) and psilocybin (2). Since June 6, 2002, these fungi have been regulated by the Narcotics and Psychotropics Control Law in Japan. Because there are many kinds of MMs and they are sold even as dry powders in local markets, it is very difficult to identify the original species of the MMs by morphological observation. Therefore, we investigated the internal transcribed spacer (ITS) region in the ribosomal RNA gene of MMs obtained in Japanese markets to classify them by a genetic approach. Based on the size and nucleotide sequence of the ITS region amplified by PCR, tested MMs were classified into 6 groups. Furthermore, a comparison of the DNA sequences of the MMs with those of authentic samples or with those found in the databases (GenBank, EMBL and DDBJ) made it possible to identify the species of tested MMs. Analysis by LC revealed that psilocin (1) was contained at the highest level in Panaeolus cyanescens among the MMs, but was absent in the Amanita species.     

Secure optical data storage with random phase key codes by use of a configuration of a joint transform correlator

A secure optical storage based on a configuration of a joint transform correlator by use of a photorefractive material is presented. A key code designed through the use of an optimized algorithm so that its Fourier transform has a uniform amplitude distribution and a uniformly random phase distribution is introduced. Original two-dimensional data and the key code are placed side-by-side at the input plane. Both of them are stored in a photorefractive material as a joint power spectrum. The retrieval of the original data can be achieved with the same key code. We can record multiple two-dimensional data in the same crystal by angular multiplexing and/or key code multiplexing.