Cholesterol‐imprinted polymer receptor prepared by a hybrid imprinting method

A novel cholesterol‐imprinted polymer (CMIP‐H) was prepared by a hybrid method of covalent imprinting and non‐covalent imprinting. This approach involves the copolymerization of a template‐containing monomer, cholesteryl 2‐hydroxyethyl methacrylate carbonate, and a cross‐linker, followed by hydrolysis to afford a flexible guest‐binding site accompanied with the easy and efficient removal of a ‘sacrificial spacer’. The effect of solvent on the binding capacity of CMIP‐H towards cholesterol was studied, indicating that a good binding capacity towards cholesterol could be achieved in a less‐polar solvent. The binding experiments of CMIP‐H towards a series of structural analogues of cholesterol, including cholesterol acetate, progesterone and stigmasterol, were carried out in hexane. The results showed that CMIP‐H almost did not bind cholesterol acetate at all because the hydrogen‐bonding site is blocked. It exhibited a similar binding towards both cholesterol and stigmasterol, but much higher binding towards progesterone. Copyright © 2005 Society of Chemical Industry     

The growth of ambient aerosols in the conditions of the respiratory system

The effect on ambient aerosols of exposure to the conditions of the respiratory system was determined by sampling simultaneously through two dichotomous samplers in parallel. In one of the samplers the aerosol was brought to 37°C and near 100% relative humidity before passing through the virtual impactor. The results show that, as a result of humidification, about 10–15% by mass of the aerosol which would normally been collected in the fine (less than 2.5 μm aerodynamic diameter) fraction of the sample grows sufficiently when humidified to be collected with the coarse fraction. It is suggested that the direct application to inhalation studies of dichotomous sampler results should be approached with some caution.     

Unsaturated polyesters. II. Structure and properties of polyester resins based on cinnamylsuccinic acid

Unsaturated Polyester resins were prepared by the reaction of cinnamylsuccinic acid with saturated diols, namely, ethylene, diethylene, propylene, dipropylene, tetramethylene, and hexamethylene glycols, and the unsaturated diols, namely, 1,4-butene- and 1,4-butynediols. All the polyester resins obtained have been characterized and were found to cure with styrene, with relatively low conversions. The properties of the cured polyesters in the form of films were determined. IR and ¹H-NMR spectroscopy were used for both qualitative and quantitative analyses of the polyesters and their hydrolyzate products, after curing with styrene.     

Experimental Procedure for Determining Transport Properties of Oxide Scales

To determine the transport properties of oxide scales growing on an alloy, a laboratory apparatus was developed which allows plotting of characteristic V = f (i) curves and oxidation with an applied electric field. The apparatus and formalism used are described; it appears that such experimental procedures allow determination of the mean ionic transport number, ti; the conductivity values σ, σ_i, and σ,_e; and the effective charge, Z*, of the moving species in the oxide scale (A1₂O₃ in the present case).     

Preparation of vanadyl porphyrin complexes from a metal-porphyrin petroleum concentrate and study of their catalytic activity

A mixture of vanadyl porphyrin complexes was obtained from a metal-porphyrin concentrate (MPC) isolated from crude petroleum by selective extraction. The petroleum MPC was subjected to demetallization and the subsequent introduction of the vanadyl cation into the porphyrin ring. It was shown that the mixture of vanadyl-porphyrin complexes obtained from MPC catalyzes the cyclohexene epoxidation reaction. On the basis of experimental data, it was assumed that the mechanism of olefin oxygenation in the presence of vanadyl porphyrin complexes is similar to the mechanism of the Prilezhaev epoxidation reaction of unsaturated compounds.     

Nanolayered lightweight flexible shields with multidirectional optical transparency

New nanolayered coatings are designed and deposited on flexible plastic substrate having the thickness of 100 /spl mu/m, in order to realize lightweight ultrathin transparent shielding foils. The structure of the coating is optimized considering three figures of merit: the average transmittance in the visible range for normal incidence, the normalized average transmittance for oblique incidence at 550 nm, and the transmittance quality factor. The nanotechnology exploited for the deposition of the transparent metals is the dual ion beam sputtering. Tests of durability, optical transmission, and shielding effectiveness demonstrate that the film has a high adhesion under mechanical solicitation, high resistance against aging, peak transmittance in the visible range higher than 70%, omnidirectional properties in the range 0/spl deg/-60/spl deg/, and shielding effectiveness of 40 dB up to 6 GHz.     

甘三酯立体专一分析的研究：（Ⅱ）甘三酯立体专一分析方法初探

在第一部分综合讨论的基础上对甘三酯立体专一分析方法作了初步探讨。以液体油(菜油)及固体脂(猪脂)为基质,系统地研究了这一分析方法,取得了经验并补充了一些具体验证方法。分析液体油的结果与文献数据相一致,分析猪脂的结果欠佳,还存在一些问题需待进一步研究。     

Determination of precompression and compression force levels to minimize tablet friability using simplex

Pilot simplex experiments for improving the tablet strength of three aspirin tablet formulations based on precompression and compression forces were presented. As each simplex moved towards the direction of the optimum, the friability was being minimized and the crushing strength was concomittantly being maximized. Because it followed a systematic direction, simplex process would locate a local optimum rapidly. The appropriate levels of precompression and compression forces that produced tablets with the desired strength were attained in five trials. By contrast, random search for this force combination required at least ten trials. Simplex technique is a cost and time effective means for determining the precompression and compression forces that will reduce the friability or increase the hardness of a tablet formulation. Results appeared to also indicate that crushing strength might be a more reliable measure of tablet strength than friability.