Microenvironment and related genes predict outcomes of patients with cervical cancer: evidence from TCGA and bioinformatic analysis

Cervical cancer (CESC) is one of the most common cancers and affects the female genital tract. Consistent HPV infection status has been determined to be a vital cause of tumorigenesis. HPV infection may induce changes to the immune system and limit the host’s immune response. Immunotherapy is therefore essential to improving the overall survival of both locally advanced and recurrent CESC patients. Using 304 relevant samples from TCGA, we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC. Functional enrichment analysis, pathway enrichment analysis, and PPI network construction were performed to explore the differentially expressed genes (DEGs). The analysis identified 425 DEGs, which included 295 up-regulated genes and 130 down-regulated genes. We established that upregulation of CCL5 was correlated with significantly better survival, meaning that CCL5 expression could serve as a novel prognostic biomarker for CESC patients. We further focused on CCL5 as a hub gene in CESC, as it had significant correlations with increased numbers of several types of immune cells. Cell-type fractions of M1 macrophages were significantly higher in the high-immune-scores group, which was associated with better overall survival. Finally, we concluded that CCL5 is a promising prognostic biomarker for CESC, as well as a novel chemotherapeutic target.     

基于UC/OS-Ⅱ的网络控制系统通讯接口设计

基于UC／OS—Ⅱ实时操作系统的网络控制系统，通过以太网将服务器和各地控制器联结，可控制多个电机协调运动．服务器采用工业级计算机，客户端(控制器)采用集成网卡接口的嵌入式系统，通过交换机进行数据交换．系统根据IP地址将命令送给各控制器，同时将客户端状态返回，并通过检验校验字符的方式减少联网过程的握手次数．其通讯的最基本函数用标准C语言编写，生成静态库文件，可直接通过工程方式使用．其通讯接口包括联网初始化、服务器和客户端网络联接、以及控制、并常处理和维护等程序。     

热镀锌板(卷)工程设计中的环境保护问题

对热镀锌板(卷)的生产工艺、主要生产设备进行了简要介绍，并就其污染源(工序)、生产过程中产生的污染物及其控制措施进行了评述，同时就设计和生产中宜注意的几个环保问题进行了分析。     

天然气空气绝热转化制合成气催化剂研究

制备了天然气空气绝热转化催化剂,采用固定床反应器进行稳定性评价试验,对反应前后的催化剂进行了分析表征。结果说明,天然气和空气绝热转化反应放热形成的高温对催化剂有烧结作用,使催化剂晶体结构发生了变化,起活性作用的金属镍和氧化铝载体转化为镍铝尖晶石结构的物质。进一步的试验表明,在1050～1300℃的温度可以把催化剂的晶体结构改变。     

钻井参数仪的模块化设计方法研究

文章以模块化设计原理为基础，讨论了钻井参数仪的模块划分，模块化设计准则和主要设计内容。采用模块化设计方法、现场设备网络的开放网络和现场总线解决方案设计的钻井参数仪，具有传输信号稳定、可靠性高、抑制噪声能力强、组建现场网络成本低等特点。     

新型微光探测器激光防护材料的研究

系统分析了微光夜视器的结构及其原理，并结合当前器件存在的激光致盲威胁，提出了增强系统安全的新措施。同时，系统地介绍了防激光滤光材料一些重要的性能参数以及滤光材料的组成、制备加工工艺。研究结果表明，新型的防激光材料能够有效地防护800nm，900nm以及10613nm等三个波长的激光，并且可见光透过率大于85％。     

合成己二腈反应技术研究——(Ⅴ)己二腈工业反应过程模拟与反应器改造

对己二腈工业反应器提出了两釜串联带回流的模型,通过模拟计算得出模型的级间返混系数 f=6的结论。该模型能较好地预测工业反应器中物料组分浓度变化和气、液两相的流动特性;指出了现工业反应器的鼓泡中和段体积偏小是造成己二酸浓度偏高的关键;提出了可以通过增加串连一个鼓泡预反应段的改造方案,能有效地降低己二酸的浓度,从7%降至4%左右,从而能较好地减缓腐蚀和结焦。     

双极关键工艺的在线统计分析

采用了双极晶体管作为双极工艺的测试结构,将在线工艺的统计分析理论应用于双极工艺,研制了双极工艺的统计分析软件。最后给出了双极工艺的某些分析结果。     

Thoracic epidural anesthesia as the last option for treating angina in a patient before coronary artery bypass surgery

Robertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. This was confirmed by the PHA-stimulated culture of peripheral blood lymphocytes. A review of the literature identifies only eight reported cases of acquired Robertsonian translocations in leukaemia. In the majority of cases the Robertsonian translocation occurs as a secondary change in a complex abnormal clone, whereas in two out of nine patients reported, including ours, it is found as a sole karyotypic abnormality.     

环境保护地理信息系统的设计

本文主要介绍基于计算机网络的通用型环境保护地理信息系统的功能和实现方法。