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1.
Corey Andrews Yiting Xu Michael Kirberger Jenny J. Yang 《International journal of molecular sciences》2021,22(1)
Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM’s ability to adapt to binding targets with different structures is related to the flexible central helix separating the N- and C-terminal lobes, which allows for conformational changes between extended and collapsed forms of the protein. CaM-binding targets are most often identified using prediction algorithms that utilize sequence and structural data to predict regions of peptides and proteins that can interact with CaM. In this review, we provide an overview of different CaM-binding proteins, the motifs through which they interact with CaM, and shared properties that make them good binding partners for CaM. Additionally, we discuss the historical and current methods for predicting CaM binding, and the similarities and differences between these methods and their relative success at prediction. As new CaM-binding proteins are identified and classified, we will gain a broader understanding of the biological processes regulated through changes in Ca2+ concentration through interactions with CaM. 相似文献
2.
Kreppner Jana M.; Rutter Michael; Beckett Celia; Castle Jenny; Colvert Emma; Groothues Christine; Hawkins Amanda; O'Connor Thomas G.; Stevens Suzanne; Sonuga-Barke Edmund J. S. 《Canadian Metallurgical Quarterly》2007,43(4):931
Longitudinal analyses on normal versus impaired functioning across 7 domains were conducted in children who had experienced profound institutional deprivation up to the age of 42 months and were adopted from Romania into U.K. families. Comparisons were made with noninstitutionalized children adopted from Romania and with nondeprived within-U.K. adoptees placed before the age of 6 months. Specifically, the validity of the assessment, the degree of continuity and change in levels of functioning from 6 to 11 years, and the factors in the pre- and postadoption environment accounting for heterogeneity in outcome were examined. Pervasive impairment was significantly raised in children experiencing institutional deprivation for ≥6 months of life, with a minority within this group showing no impairment. There was no additional significant effect of duration of deprivation beyond the 6-month cutoff, and few other predictors explained outcome. The pattern of normality/impairment was mainly established by 6 years of age, with considerable continuity at the individual level between 6 and 11 years. The findings are discussed in terms of the possibility of a sensitive period for development. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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4.
美国大学教学评估及其对中国高等教育的启示 总被引:4,自引:0,他引:4
美国大学和学院,学生对教师教学进行有效性评估。不同大学对教学有不同要求和标准;美国学术界对教学评估体系利与弊展开过辩论,而学生和老师的背景特征可能引起偏见。美国学生对老师进行教学评估的体系,对中国高等教育教学可能有一定的他石意义,但是,评估体系的现实条件有差异,中国不应当照抄或照搬美国教学评估,尤其应该摒弃将教与学关系扭曲为买方和卖方关系的观念。取其精华而弃其糟粕,建立适应中国的教学评估体系才能提高高等教育质量。 相似文献
5.
Tooraj Hashemi Jenny Illingsworth Farhad Golestani-Fard 《Journal of the American Ceramic Society》1991,74(3):662-665
X-ray photoelectron spectroscopy (XPS) has been employed to investigate the chemical nature of samples of dicadmium stannate (Cd2 SnO4 ) in the as-fired, electrochemically reduced, and reoxidized states. The reduction of Cd2 SnO4 was found to be associated with a dramatic color change from bright yellow to dark green, a phenomenon commonly known as the electrochromic effect. Both quantitative XPS results and binding energy measurements proved that, upon exposure of the reduced ceramic bodies to air, the Sn2+ to Sn4+ transition readily took place to produce the intermediate compound, Cd2 SnO3 with divalent tin. Prolonged exposure to the atmosphere did not result in further progress of reoxidation extending to monovalent cadmium. However, complete reoxidation of the reduced samples was possible by annealing in air at 350°C for a short period of time, e.g., 3 h, by which the original features of the as-fired state such as color and electrical conductivity were restored. The results also showed that reoxidized samples at high temperature assume the same XPS characteristics as those of as-fired ceramics. 相似文献
6.
ABSTRACT Many designers and User Interface (UI) educators discuss principles to be followed when designing the functional aspects of a UI. However, many UI principles have been proposed, scattered in scientific papers and teaching books. Some principles are different, and many are somehow similar or overlapping with others. This makes it very difficult to comprehend where to pay attention to when designing a UI. In this paper, we perform a systematic literature review to first identify the most relevant authors in the domain of functional UI design principles. Focusing on the three most cited works of these authors, we extracted 257 principles. We next analyzed all these principles, unified their variants, and, considering their scientific influence, finally derived a shorter and core selection of 36 principles. This core selection provides educators and UI designers with a clear path to teach, evaluate, learn and improve the UI functional design. 相似文献
7.
Rogers Jeffrey M. Jensen Jenny Valderrama Joaquin T. Johnstone Stuart J. Wilson Peter H. 《Virtual Reality》2021,25(2):357-366
Virtual Reality - Stroke rehabilitation suffers from low levels of patient engagement, impeding recovery. Virtual rehabilitation (VR) approaches can improve patient outcomes; however, there is... 相似文献
8.
C. -X. Ji Peter F. Ladwig Ronald D. Ott Y. Yang Joshua J. Yang Y. Austin Chang Eric S. Linville Jenny Gao Bharat B. Pant 《JOM Journal of the Minerals, Metals and Materials Society》2006,58(6):50-54
Sputter-deposited, equiatomic PtMn thin films have application in giant magnetoresistive spin valves, tunneling magnetoresistive
spin valves, and magnetic random access memory. However, the as-deposited films are found to be a disordered A1 phase in a
paramagnetic state rather than an antiferromagnetic phase with L10 structure, which is needed for device operation. Therefore, a postannealing step is required to induce the phase transformation
from the asdeposited A1 face-centered-cubic phase to the antiferromagnetic L10 phase. The A1 to L10 metastable transformation was studied by x-ray diffraction and differential-scanning calorimetry. An exothermic transformation
enthalpy of −12.1 kJ/mol of atoms was determined. The transformation kinetics were simulated using the Johnson-Mehl-Avrami
analysis. 相似文献
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