Characterization,in vitro bioactivity and biological studies of sol-gel-derived TiO2 substituted 58S bioactive glass

Bioactive glasses (BGs) have been used for bone formation and bone repair processes in recent years. This study investigated the titanium substitution effect on 58S BGs (Ti-BGs) 60SiO₂-(36 − X)CaO-4P₂O₅-XTiO₂ (X = 0, 3, and 5 mol.%) prepared by the sol-gel technique, and the main goal was to find the optimum amount of titanium in Ti-BGs. Synthesized BGs, which were investigated after immersion in simulated body fluid (SBF), were tested by X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy. Moreover alkaline phosphate (ALP) activity, 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and antibacterial studies were employed to investigate the biological properties of Ti-BGs. According to the FTIR and XRD test results, hydroxyapatite (HA) formation on Ti-BGs surfaces was confirmed. Meanwhile, the presence of 5 mol.% compared to 3 mol.% increased the HA grain distribution and their size on the Ti-BGs surface. Additionally, MTT and ALP results confirmed that the optimal amount of titanium substitution in BG was 5 mol.%. Since 5 mol.% Ti incorporated BG (BG-5) had the highest biocompatibility level, antibacterial properties, maximum cell proliferation, and ALP activity among the synthesized Ti-BGs, it is presented as the best candidate for further in vivo investigations.     

Optimal motion planning for parallel robots via convex optimization and receding horizon

In this paper, the problem of motion planning for parallel robots in the presence of static and dynamic obstacles has been investigated. The proposed algorithm can be regarded as a synergy of convex optimization with discrete optimization and receding horizon. This algorithm has several advantages, including absence of trapping in local optimums and a high computational speed. This problem has been fully analyzed for two three-DOF parallel robots, ie 3s-RPR parallel mechanism and the so-called Tripteron, while the shortest path is selected as the objective function. It should be noted that the first case study is a parallel mechanism with complex singularity loci expression from a convex optimization problem standpoint, while the second case is a parallel manipulator for which each limb has two links, an issue which increases the complexity of the optimization problem. Since some of the constraints are non-convex, two approaches are introduced in order to convexify them: (1) A McCormick-based relaxation merged with a branch-and-prune algorithm to prevent it from becoming too loose and (2) a first-order approximation which linearizes the non-convex quadratic constraints. The computational time for the approaches presented in this paper is considerably low, which will pave the way for online applications.     

Using correlation coefficients for locating partial discharge in power transformer

Most serious failure of power transformers is due to the insulation breakdown. Partial discharge (PD) that damages insulation by gradual erosion is major source of insulation failure. The effective ability of the wavelet packets analysis as a tool for disk-to-disk partial discharge faults detection and localization in transformer windings is shown in this paper. Techniques for locating a PD source are of the major importance in both the maintenance and repair of a transformer. One of the most well-known methods of PD localization in transformers is based on winding modeling and current of neutral point analysis. Since the impedance between PD location and neutral point of winding depends on the PD location in respect to neutral point, the frequency spectrum of neutral point current varies when the PD location changes. In the other word, the current components of neutral points vary according to the place where PD occurs. So in this paper, detailed model of transformer winding is modeled and the neutral point current is studied for locating PD. The used method is validated by the simulated model of transformer windings. This model produces a very acceptable current when compared to the experimental data. In this paper for locating partial discharge (PD) in transformer windings, a simulated model is developed for the transformer winding and the PD phenomenon mechanism. The impulse current test and wavelet packets transformation are used to locate PD. It is shown that the neutral current measurement of the transformer winding has useful information about PD location.     

New Approaches in Monitoring Multivariate Categorical Processes based on Contingency Tables in Phase II

In some statistical process control (SPC) applications, quality of a process or product is characterized by contingency table. Contingency tables describe the relation between two or more categorical quality characteristics. In this paper, two new control charts based on the WALD and Stuart score test statistics are designed for monitoring of contingency table‐based processes in Phase‐II. The performances of the proposed control charts are compared with the generalized linear test (GLT) control chart proposed in the literature. The results show the better performance of the proposed control charts under small and moderate shifts. Moreover, new schemes are proposed to diagnose which cell corresponding to different levels of categorical variables is responsible for out‐of‐control signal. In addition, we propose EWMA–WALD and EWMA–Stuart score test control charts to improve the performance of Shewhart‐based control charts in detecting small and moderate shifts in contingency table parameters. Meanwhile, we compare the performances of two proposed EWMA‐based control charts with the ones of three existing control charts called EWMA–GLT, EWMA–GLRT and an EWMA‐type control chart for multivariate binomial/multinomial processes along with the ones of the corresponding Shewhart‐based control charts. A numerical example is given to show the efficiency of the proposed methods. Finally, the effect of parameter estimation in Phase I based on m historical contingency table on the performance of the Shewhart‐based control charts is studied. Copyright © 2016 John Wiley & Sons, Ltd.     

Experimental investigation of the flow-induced motion of a square-section cylinder

The flow-induced motion(FIM)of an elastically mounted square-section cylinder is experimentally investigated over a wide range of Reynolds numbers(1.5×104＜Re＜7....     

A Comprehensive Study of Market Prediction from Efficient Market Hypothesis up to Late Intelligent Market Prediction Approaches

Computational Economics - This paper has scrutinized the process of testing market efficiency, data generation process and the feasibility of market prediction with a detailed, coherent and...     

Identifying the time of step change in binary profiles

Control charts are intended to aid quality practitioners in monitoring whether a change has occurred in a process. When a control chart indicates an out-of-control signal, it means that the process has changed. However, control chart signals do not indicate the real time of process changes; so estimators are applied to indicate the time when a change in the process takes place, which is referred to as the change point. This paper provides a maximum likelihood estimator to identify the real time of a step change in phase II monitoring of binary profiles, in which the quality of a process is characterized by a logistic regression between the response and predictor variables. Simulation studies are provided to evaluate the effectiveness of the change point estimator.     

Matrix based method for synthesis of main intensified and integrated distillation sequences

The objective of many studies in this area has involved access to a column-sequencing algorithm enabling designers and researchers alike to generate a wide range of sequences in a broad search space, and be as mathematically and as automated as possible for programing purposes and with good generality. In the present work an algorithm previously developed by the authors, called the matrix method, has been developed much further. The new version of the algorithm includes thermally coupled, thermodynamically equivalent, intensified, simultaneous heat and mass integrated and divided-wall column sequences which are of gross application and provide vast saving potential both on capital investment, operating costs and energy usage in industrial applications. To demonstrate the much wider searchable space now accessible, a three component separation has been thoroughly examined as a case study, always resulting in an integrated sequence being proposed as the optimum.     

A critical review of bioceramics for magnetic hyperthermia

Magnetic hyperthermia (HT) using biocompatible ceramics is a ground-breaking, competent, and safe thermo-therapeutic strategy for cancer treatment. The magnetic properties of bioceramics, along with their structure and synthesis parameters, are responsible for the controlled heating of malignant tumors and are the key to clinical success. After providing a brief overview of magnetism and its significance in biomedicine, this review deals with materials selection and synthesis methods of bioceramics/glasses used for HT. Relevant research carried out on promising bioceramics for magnetic HT, with a focus on their size, shape, surface functionalization, magnetic field parameters, and in vitro/in vivo properties to optimize cancer therapy, is also discussed. Recent progress in magnetic HT combined with chemotherapy and phototherapy is especially highlighted, with the aim to provide interdisciplinary knowledge to advance further the applications of bioceramics in this field.