Characterization,in vitro bioactivity and biological studies of sol-gel-derived TiO2 substituted 58S bioactive glass |
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Authors: | Amirhossein Moghanian Saba Nasiripour Atiyyeh Koohfar Mohammad Sajjadnejad SeyedMohammad Hosseini Mohsen Taherkhani Zahra Miri Seyed Hesamedin Hosseini Mehrnaz Aminitabar Ali Rashvand |
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Affiliation: | 1. Department of Materials Engineering, Imam Khomeini International University, Qazvin, Iran;2. School of Metallurgy and Materials Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran;3. Department of Materials Engineering, School of Engineering, Yasouj University, Yasouj, Iran;4. Qazvin Science and Technology Park, Qazvin, Iran;5. Department of Dermatology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran;6. Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran |
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Abstract: | Bioactive glasses (BGs) have been used for bone formation and bone repair processes in recent years. This study investigated the titanium substitution effect on 58S BGs (Ti-BGs) 60SiO2-(36 − X)CaO-4P2O5-XTiO2 (X = 0, 3, and 5 mol.%) prepared by the sol-gel technique, and the main goal was to find the optimum amount of titanium in Ti-BGs. Synthesized BGs, which were investigated after immersion in simulated body fluid (SBF), were tested by X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy. Moreover alkaline phosphate (ALP) activity, 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and antibacterial studies were employed to investigate the biological properties of Ti-BGs. According to the FTIR and XRD test results, hydroxyapatite (HA) formation on Ti-BGs surfaces was confirmed. Meanwhile, the presence of 5 mol.% compared to 3 mol.% increased the HA grain distribution and their size on the Ti-BGs surface. Additionally, MTT and ALP results confirmed that the optimal amount of titanium substitution in BG was 5 mol.%. Since 5 mol.% Ti incorporated BG (BG-5) had the highest biocompatibility level, antibacterial properties, maximum cell proliferation, and ALP activity among the synthesized Ti-BGs, it is presented as the best candidate for further in vivo investigations. |
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Keywords: | bioactive glass biomedical applications hydroxyapatite sol-gel TiO2 |
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