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1.
Corey Andrews Yiting Xu Michael Kirberger Jenny J. Yang 《International journal of molecular sciences》2021,22(1)
Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM’s ability to adapt to binding targets with different structures is related to the flexible central helix separating the N- and C-terminal lobes, which allows for conformational changes between extended and collapsed forms of the protein. CaM-binding targets are most often identified using prediction algorithms that utilize sequence and structural data to predict regions of peptides and proteins that can interact with CaM. In this review, we provide an overview of different CaM-binding proteins, the motifs through which they interact with CaM, and shared properties that make them good binding partners for CaM. Additionally, we discuss the historical and current methods for predicting CaM binding, and the similarities and differences between these methods and their relative success at prediction. As new CaM-binding proteins are identified and classified, we will gain a broader understanding of the biological processes regulated through changes in Ca2+ concentration through interactions with CaM. 相似文献
2.
A comparison between different PMD compensation techniques 总被引:17,自引:0,他引:17
Sunnerud H. Chongjin Xie Karlsson M. Samuelsson R. Andrekson P.A. 《Lightwave Technology, Journal of》2002,20(3):368-378
We quantify the benefits of using different techniques for compensation of polarization mode dispersion (PMD) in fiber-optic communication systems by means of numerical simulations. This is done both with respect to PMD-induced pulse broadening and in terms of system outage probability for different data formats [nonreturn-to-zero (NRZ) and return-to-zero (RZ)]. Attention is focused on simple and relevant single- and double-stage post-transmission compensators with a few degrees of freedom (DOF). It is generally believed that a PMD compensator with a polarization controller and a variable delay line can only compensate the PMD to the first order. We show, from analytical results, the counterintuitive fact that this scheme can also partially compensate for higher order PMD. We also investigate the benefit of using a polarizer as compensation element where the optical average power can be used as a feedback signal 相似文献
3.
4.
Dr. V. Recina Dr. D. Lundström B. Karlsson 《Metallurgical and Materials Transactions A》2002,33(9):2869-2881
The influence of chemical composition on the microstructure of the γ-titanium aluminide alloy Ti-48Al-2W-0.5Si (at. pct) and the accompanying tensile, low-cycle fatigue, and creep properties
has been evaluated. The study showed that small variations in chemical composition and casting procedures resulted in considerable
variations in the microstructure, yielding vastly different mechanical properties. Low contents of aluminum and tungsten led
to a coarse-grained lamellar (γ/α
2) microstructure with high creep resistance. A composition close to the nominal one produced a duplex (γ+γ/α
2) structure with favorable strength, ductility, and low-cycle fatigue properties. By controlling the solidification and cooling
rates at casting, a pseudoduplex (PS-DP) microstructure with a unique combination of high strength and high fatigue and creep
resistance can be obtained. These unique properties can be explained by the diffuse boundaries between the relatively small
γ grains and the neighboring lamellar colonies, combined with semicoherent interfaces between the γ and α
2 phases. At tensile and low-cycle fatigue loading, these boundaries act like high-angle boundaries, producing a virtually
fine-grained material promoting strength, whereas at creep loading, grain-boundary sliding is hindered in the semicoherent
interfaces leading to high creep resistance. 相似文献
5.
Kreppner Jana M.; Rutter Michael; Beckett Celia; Castle Jenny; Colvert Emma; Groothues Christine; Hawkins Amanda; O'Connor Thomas G.; Stevens Suzanne; Sonuga-Barke Edmund J. S. 《Canadian Metallurgical Quarterly》2007,43(4):931
Longitudinal analyses on normal versus impaired functioning across 7 domains were conducted in children who had experienced profound institutional deprivation up to the age of 42 months and were adopted from Romania into U.K. families. Comparisons were made with noninstitutionalized children adopted from Romania and with nondeprived within-U.K. adoptees placed before the age of 6 months. Specifically, the validity of the assessment, the degree of continuity and change in levels of functioning from 6 to 11 years, and the factors in the pre- and postadoption environment accounting for heterogeneity in outcome were examined. Pervasive impairment was significantly raised in children experiencing institutional deprivation for ≥6 months of life, with a minority within this group showing no impairment. There was no additional significant effect of duration of deprivation beyond the 6-month cutoff, and few other predictors explained outcome. The pattern of normality/impairment was mainly established by 6 years of age, with considerable continuity at the individual level between 6 and 11 years. The findings are discussed in terms of the possibility of a sensitive period for development. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
7.
Multilayer calculations by conventional matrix methods for dielectricum/noble metal/dielectricum systems on glass have been performed. The aim has been to maximize the integrated parameters for solar transmission, Tsol, and transmission of visible light, Teye We have found that Ag is superior for maximizing the transmittance over the narrow visible wavelength range owing to the low internal absorptance. When solar energy transmission is considered multilayers based on Au are the best choice for metal film thicknesses above 15 nm. For thinner films, Ag is still to be preferred. 相似文献
8.
Quinine induces changes in the motion of the cupula in the lateral line canal of the African knife-fish in response to sinusoidal water movements. Two different phases in the action of quinine on the cupular frequency response can be discerned. In the first phase the best frequency, i.e., the frequency at which the cupular vibratory displacement is maximal in response to constant-amplitude sinusoidal canal fluid displacement, shifts toward higher frequencies. During this phase, lasting about 70-100 min, the best frequency increases by a factor between 1.3 and 1.5. In the second phase, during roughly the following 90 min, the best frequency decreases gradually to a value 0.3-0.5 times that observed before the application of quinine. 相似文献
9.
Fifty-five patients (46 women and 9 men) with craniomandibular disorders and a history of pain of at least 6 months' duration participated in this trial. The patients were randomly assigned to three groups: one group to receive acupuncture; one group to receive occlusal splint therapy; and one group to act as controls. Pressure pain threshold, clinical dysfunction score, and visual analog scale measures were used to evaluate patients before, immediately after, and 6 months after treatment. A moderate, but statistically significant, correlation was found between pressure pain threshold and the number of tender spots in the masticatory muscles (tau = -.43; P < .001), degree of tenderness in the masticatory muscles (tau = -.43; P < .001), clinical dysfunction score (tau = .32; P < .001), and the visual analog scale (tau = -.25; P < .01). The short-term results showed a statistically significant improvement in all evaluations for both treatment groups. No significant differences were found in the control group. The improvements resulted in significant differences between the control and each treatment group immediately after treatment. At the 6-month follow-up, no significant differences in pressure pain threshold or clinical dysfunction score were found in the two treatment groups compared with the short-term results. 相似文献
10.
Cornelius Temmel Nils-Gunnar Ingesten Birger Karlsson 《Metallurgical and Materials Transactions A》2006,37(10):2995-3007
Anisotropy of forged steel components is especially adverse when it concerns rotationally symmetric components. Manganese
sulfides (MnS) in steels may be desired for their improvement of machining properties; however, they also deteriorate fatigue
behavior. A quantification of the effect of MnS on anisotropy is necessary to find an optimum for component dimensioning.
To isolate the influence of MnS on anisotropy only, high cleanness of the test material is required. The test material in
the current investigation was molten in a vacuum furnace to high-cleanness composition. Materials with two different S levels
were produced to detect variations in anisotropy according to amount, shape, and distribution of the MnS inclusions. The two
batches were cross-rolled to plates with a deformation ratio of 4.5. The MnS phase constitutes, upon forging or rolling, pancake-shaped
inclusions. In the case of cross-rolling, an in-plane rotational symmetry of the inclusions could be created. The shape and
size of these inclusions are essential for the mechanical behavior of the material. Push-pull fatigue testing was performed
in longitudinal (in plane) and short transversal directions relative to the rolling plane. The results showed strong anisotropy
of the fatigue behavior with inferior performance in short transverse directions where the principal stress is perpendicular
to the flattened inclusions. The anisotropy was somewhat more pronounced for the high-S material, resulting from a different
fatigue crack growth mechanism. 相似文献