Structural Aspects and Prediction of Calmodulin-Binding Proteins

Calmodulin (CaM) is an important intracellular protein that binds Ca²⁺ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM’s ability to adapt to binding targets with different structures is related to the flexible central helix separating the N- and C-terminal lobes, which allows for conformational changes between extended and collapsed forms of the protein. CaM-binding targets are most often identified using prediction algorithms that utilize sequence and structural data to predict regions of peptides and proteins that can interact with CaM. In this review, we provide an overview of different CaM-binding proteins, the motifs through which they interact with CaM, and shared properties that make them good binding partners for CaM. Additionally, we discuss the historical and current methods for predicting CaM binding, and the similarities and differences between these methods and their relative success at prediction. As new CaM-binding proteins are identified and classified, we will gain a broader understanding of the biological processes regulated through changes in Ca²⁺ concentration through interactions with CaM.     

Normality and impairment following profound early institutional deprivation: A longitudinal follow-up into early adolescence.

Longitudinal analyses on normal versus impaired functioning across 7 domains were conducted in children who had experienced profound institutional deprivation up to the age of 42 months and were adopted from Romania into U.K. families. Comparisons were made with noninstitutionalized children adopted from Romania and with nondeprived within-U.K. adoptees placed before the age of 6 months. Specifically, the validity of the assessment, the degree of continuity and change in levels of functioning from 6 to 11 years, and the factors in the pre- and postadoption environment accounting for heterogeneity in outcome were examined. Pervasive impairment was significantly raised in children experiencing institutional deprivation for ≥6 months of life, with a minority within this group showing no impairment. There was no additional significant effect of duration of deprivation beyond the 6-month cutoff, and few other predictors explained outcome. The pattern of normality/impairment was mainly established by 6 years of age, with considerable continuity at the individual level between 6 and 11 years. The findings are discussed in terms of the possibility of a sensitive period for development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Bilateral loss of vestibular function: clinical findings in 53 patients

The clinical presentations and aetiologies of a series of 53 cases of bilateral vestibular failure (BVF) seen by the authors over a decade were evaluated by retrospective review of the medical records. Thirty-nine per cent of patients had associated neurological disease; 13% had a progressive cerebellar syndrome with disabling gait ataxia, abnormal eye movements and cerebellar atrophy on neuro-imaging. BVF was usually unsuspected. Nine per cent had cranial or peripheral neuropathies and in this group there was no abnormality of brain stem/cerebellar oculomotor function, but hearing loss was common. Eleven per cent revealed BVF and hearing loss secondary to meningitis, and 6% had other neurological disorders. Idiopathic BVF was found in 21% of cases, characterised by paroxysmal vertigo and/or oscillopsia, but no abnormal clinical signs. Gentamicin ototoxicity accounted for a further 17%, while autoimmune disease was present in 9% of patients. Otological or neoplastic disease was diagnosed in the remaining 13% of patients. It was concluded that neurological, audiological and ocular motor assessments allow the probable cause of BVF to be defined in approximately 80% of cases. A group of BVF related to autoimmune pathologies is reported for the first time, indicating the need for immunological screening. Idiopathic BVF may present with only minor visual or vestibular symptoms, while in patients with cerebellar degeneration, BVF may be unsuspected and, thus, underdiagnosed.     

美国大学教学评估及其对中国高等教育的启示

美国大学和学院，学生对教师教学进行有效性评估。不同大学对教学有不同要求和标准；美国学术界对教学评估体系利与弊展开过辩论，而学生和老师的背景特征可能引起偏见。美国学生对老师进行教学评估的体系，对中国高等教育教学可能有一定的他石意义，但是，评估体系的现实条件有差异，中国不应当照抄或照搬美国教学评估，尤其应该摒弃将教与学关系扭曲为买方和卖方关系的观念。取其精华而弃其糟粕，建立适应中国的教学评估体系才能提高高等教育质量。     

Equi-affine Invariant Geometry for Shape Analysis

Traditional models of bendable surfaces are based on the exact or approximate invariance to deformations that do not tear or stretch the shape, leaving intact an intrinsic geometry associated with it. These geometries are typically defined using either the shortest path length (geodesic distance), or properties of heat diffusion (diffusion distance) on the surface. Both measures are implicitly derived from the metric induced by the ambient Euclidean space. In this paper, we depart from this restrictive assumption by observing that a different choice of the metric results in a richer set of geometric invariants. We apply equi-affine geometry for analyzing arbitrary shapes with positive Gaussian curvature. The potential of the proposed framework is explored in a range of applications such as shape matching and retrieval, symmetry detection, and computation of Voroni tessellation. We show that in some shape analysis tasks, equi-affine-invariant intrinsic geometries often outperform their Euclidean-based counterparts. We further explore the potential of this metric in facial anthropometry of newborns. We show that intrinsic properties of this homogeneous group are better captured using the equi-affine metric.     

Laplacian colormaps: a framework for structure‐preserving color transformations

Mappings between color spaces are ubiquitous in image processing problems such as gamut mapping, decolorization, and image optimization for color‐blind people. Simple color transformations often result in information loss and ambiguities, and one wishes to find an image‐specific transformation that would preserve as much as possible the structure of the original image in the target color space. In this paper, we propose Laplacian colormaps, a generic framework for structure‐preserving color transformations between images. We use the image Laplacian to capture the structural information, and show that if the color transformation between two images preserves the structure, the respective Laplacians have similar eigenvectors, or in other words, are approximately jointly diagonalizable. Employing the relation between joint diagonalizability and commutativity of matrices, we use Laplacians commutativity as a criterion of color mapping quality and minimize it w.r.t. the parameters of a color transformation to achieve optimal structure preservation. We show numerous applications of our approach, including color‐to‐gray conversion, gamut mapping, multispectral image fusion, and image optimization for color deficient viewers.     

X-ray Photoelectron Spectroscopy of Cadmium Tin Oxide Ceramics in As-Fired and Electrochemically Reduced Forms

X-ray photoelectron spectroscopy (XPS) has been employed to investigate the chemical nature of samples of dicadmium stannate (Cd₂SnO₄) in the as-fired, electrochemically reduced, and reoxidized states. The reduction of Cd₂SnO₄ was found to be associated with a dramatic color change from bright yellow to dark green, a phenomenon commonly known as the electrochromic effect. Both quantitative XPS results and binding energy measurements proved that, upon exposure of the reduced ceramic bodies to air, the Sn²⁺ to Sn⁴⁺ transition readily took place to produce the intermediate compound, Cd₂SnO₃ with divalent tin. Prolonged exposure to the atmosphere did not result in further progress of reoxidation extending to monovalent cadmium. However, complete reoxidation of the reduced samples was possible by annealing in air at 350°C for a short period of time, e.g., 3 h, by which the original features of the as-fired state such as color and electrical conductivity were restored. The results also showed that reoxidized samples at high temperature assume the same XPS characteristics as those of as-fired ceramics.     

Unifying Functional User Interface Design Principles

ABSTRACT

Many designers and User Interface (UI) educators discuss principles to be followed when designing the functional aspects of a UI. However, many UI principles have been proposed, scattered in scientific papers and teaching books. Some principles are different, and many are somehow similar or overlapping with others. This makes it very difficult to comprehend where to pay attention to when designing a UI. In this paper, we perform a systematic literature review to first identify the most relevant authors in the domain of functional UI design principles. Focusing on the three most cited works of these authors, we extracted 257 principles. We next analyzed all these principles, unified their variants, and, considering their scientific influence, finally derived a shorter and core selection of 36 principles. This core selection provides educators and UI designers with a clear path to teach, evaluate, learn and improve the UI functional design.