全文获取类型
收费全文 | 8198篇 |
免费 | 1039篇 |
国内免费 | 154篇 |
专业分类
电工技术 | 17篇 |
综合类 | 360篇 |
化学工业 | 3973篇 |
金属工艺 | 205篇 |
机械仪表 | 46篇 |
建筑科学 | 43篇 |
矿业工程 | 38篇 |
能源动力 | 45篇 |
轻工业 | 3969篇 |
水利工程 | 18篇 |
石油天然气 | 106篇 |
武器工业 | 2篇 |
无线电 | 72篇 |
一般工业技术 | 246篇 |
冶金工业 | 61篇 |
原子能技术 | 24篇 |
自动化技术 | 166篇 |
出版年
2024年 | 27篇 |
2023年 | 157篇 |
2022年 | 478篇 |
2021年 | 577篇 |
2020年 | 300篇 |
2019年 | 286篇 |
2018年 | 281篇 |
2017年 | 258篇 |
2016年 | 332篇 |
2015年 | 329篇 |
2014年 | 397篇 |
2013年 | 489篇 |
2012年 | 582篇 |
2011年 | 585篇 |
2010年 | 403篇 |
2009年 | 432篇 |
2008年 | 341篇 |
2007年 | 520篇 |
2006年 | 480篇 |
2005年 | 358篇 |
2004年 | 279篇 |
2003年 | 257篇 |
2002年 | 205篇 |
2001年 | 185篇 |
2000年 | 149篇 |
1999年 | 110篇 |
1998年 | 89篇 |
1997年 | 74篇 |
1996年 | 62篇 |
1995年 | 44篇 |
1994年 | 55篇 |
1993年 | 44篇 |
1992年 | 48篇 |
1991年 | 30篇 |
1990年 | 20篇 |
1989年 | 21篇 |
1988年 | 14篇 |
1987年 | 12篇 |
1986年 | 13篇 |
1985年 | 10篇 |
1984年 | 10篇 |
1983年 | 7篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1977年 | 3篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 5篇 |
1951年 | 6篇 |
排序方式: 共有9391条查询结果,搜索用时 31 毫秒
1.
2.
3.
Jiao Zhang Junjie Li Ayesha Murtaza Aamir Iqbal Lijuan Zhu Shinawar Waseem Ali Muhammad Usman Roshan Yameen Siyi Pan Wanfeng Hu 《International Journal of Food Science & Technology》2022,57(2):963-973
This work evaluated the synergistic effects of combined high-intensity ultrasound (HIU) with β-cyclodextrin (β-CD) treatments on inhibiting browning of apple juice and explored the mechanism through simulation system. The combined treatment of 300 W HIU with 0.006 g mL−1 β-CD had a synergistic impact on maintaining juice colour, resulting in a 39.06% reduction in browning degree, only a 36.64% decrease in total phenolic content, and a 17.82% reduction in PPO activity. The inhibition of enzymatic browning in simulated system revealed that HIU suppressed the enzyme (Polyphenol oxidase, PPO) and β-CD inhibited enzyme (PPO) and embedded substrate (polyphenol). The results of spectroscopic analysis showed that the particle-size distribution of PPO narrowed, the content of α-helix in the secondary structure increased, the fluorescence intensity increased, and the maximum wavelength was red-shifted after HIU and β-CD treatment. Changes in structure could further result in PPO activity loss. Hence, the combined treatment could synthetically alleviate the browning of apple juice. 相似文献
4.
Nienke Visser Harm Jan Lourens Gerwin Huls Edwin Bremer Valerie R. Wiersma 《International journal of molecular sciences》2021,22(5)
Elevated activation of the autophagy pathway is currently thought to be one of the survival mechanisms allowing therapy-resistant cancer cells to escape elimination, including for cytarabine (AraC)-resistant acute myeloid leukemia (AML) patients. Consequently, the use of autophagy inhibitors such as chloroquine (CQ) is being explored for the re-sensitization of AraC-resistant cells. In our study, no difference in the activity of the autophagy pathway was detected when comparing AraC-Res AML cell lines to parental AraC-sensitive AML cell lines. Furthermore, treatment with autophagy inhibitors CQ, 3-Methyladenine (3-MA), and bafilomycin A1 (BafA1) did not re-sensitize AraC-Res AML cell lines to AraC treatment. However, in parental AraC-sensitive AML cells, treatment with AraC did activate autophagy and, correspondingly, combination of AraC with autophagy inhibitors strongly reduced cell viability. Notably, the combination of these drugs also yielded the highest level of cell death in a panel of patient-derived AML samples even though not being additive. Furthermore, there was no difference in the cytotoxic effect of autophagy inhibition during AraC treatment in matched de novo and relapse samples with differential sensitivity to AraC. Thus, inhibition of autophagy may improve AraC efficacy in AML patients, but does not seem warranted for the treatment of AML patients that have relapsed with AraC-resistant disease. 相似文献
5.
Ewa Maria Kratz Katarzyna Sokiewicz Adriana Kubis-Kubiak Agnieszka Piwowar 《International journal of molecular sciences》2021,22(2)
Sirtuins (SIRTs), enzymes from the family of NAD+-dependent histone deacetylases, play an important role in the functioning of the body at the cellular level and participate in many biochemical processes. The multi-directionality of SIRTs encourages scientists to undertake research aimed at understanding the mechanisms of their action and the influence that SIRTs have on the organism. At the same time, new substances are constantly being sought that can modulate the action of SIRTs. Extensive research on the expression of SIRTs in various pathological conditions suggests that regulation of their activity may have positive results in supporting the treatment of certain metabolic, neurodegenerative or cancer diseases or this connected with oxidative stress. Due to such a wide spectrum of activity, SIRTs may also be a prognostic markers of selected pathological conditions and prove helpful in assessing their progression, especially by modulating their activity. The article presents and discusses the activating or inhibiting impact of individual SIRTs modulators. The review also gathered selected currently available information on the expression of SIRTs in individual disease cases as well as the biological role that SIRTs play in the human organism, also in connection with oxidative stress condition, taking into account the progress of knowledge about SIRTs over the years, with particular reference to the latest research results. 相似文献
6.
Jennie O'Loughlin Silvia Napolitano Fahad Alkhathami Cillian O'Beirne Daniel Marhöfer Megan O'Shaughnessy Prof. Orla Howe Prof. Matthias Tacke Dr. Marina Rubini 《Chembiochem : a European journal of chemical biology》2021,22(6):1093-1098
Antibiotic resistance is a growing problem for public health and associated with increasing economic costs and mortality rates. Silver and silver-related compounds have been used for centuries due to their antimicrobial properties. In this work, we show that 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate/NHC*-Ag-OAc (SBC3) is a reversible, high affinity inhibitor of E. coli thioredoxin reductase (TrxR; Ki=10.8±1.2 nM). Minimal inhibition concentration (MIC) tests with different E. coli and P. aeruginosa strains demonstrated that SBC3 can efficiently inhibit bacterial cell growth, especially in combination with established antibiotics like gentamicin. Our results show that SBC3 is a promising antibiotic drug candidate targeting bacterial TrxR. 相似文献
7.
8.
9.
Angiotensin I‐converting enzyme inhibitory and Ca‐binding activities of peptides prepared from tuna cooking juice and spleen proteases
下载免费PDF全文
![点击此处可从《International Journal of Food Science & Technology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jirawadee Kasiwut Wirote Youravong Pittaya Adulyatham Nualpun Sirinupong 《International Journal of Food Science & Technology》2015,50(2):389-395
Tuna cooking juice is a by‐product from the tuna canning industry. In this study, tuna cooking juice was hydrolysed by proteases extracted from the spleen. Tuna cooking juice showed the highest ACE inhibitory and Ca‐binding activities after hydrolysis for 270 and 180 min, respectively. The hydrolysate was further fractionated by ultrafiltration. The permeate exhibited highest ACE inhibitory and Ca‐binding activities when passed through 1 and 5 kDa cut‐off membranes, respectively. Gel filtration chromatography was used to determine the MW of bioactive peptides that exhibited highest ACE inhibitory and Ca‐binding activities. Those peptides that exhibited highest ACE inhibitory and Ca‐binding activities were the MW range of 238–829 Da and 1355–1880 Da, respectively. These results suggest that the tuna cooking juice and the spleen protease extract are a potential source of bioactive peptides that can be utilised as bioactive ingredients in functional food and nutraceuticals. 相似文献
10.