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1.
Ping-Chi Hsu Jia-Ying Jhong Li-Ping Huang Kuo-Hsin Lee Hsin-Pao Chen Yue-Leon Guo 《International journal of molecular sciences》2021,22(8)
Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in the manufacture of polyvinylchloride plastics and has been associated with concerns regarding male reproductive toxicity. In this study, we hypothesized that maternal exposure to DEHP induces transgenerational inheritance of adult-onset adverse reproductive outcomes through the male germline in the F1, F2, and F3 generations of male offspring. Pregnant rats were treated with 5 or 500 mg of DEHP/kg/day through gavage from gestation day 0 to birth. The offspring body weight, anogenital distance (AGD), anogenital index (AGI), sperm count, motility, and DNA fragmentation index (DFI) were measured for all generations. Methyl-CpG binding domain sequencing was performed to analyze sperm DNA methylation status in the F3. DEHP exposure at 500 mg/kg affected AGD, AGI, sperm count, mean DFI, and %DFI in the F1; AGD, sperm count, and mean DFI in the F2; and AGD, AGI, mean DFI, and %DFI in the F3. DEHP exposure at 5 mg/kg affected AGD, AGI, sperm count, and %DFI in the F1; sperm count in the F2; and AGD and AGI in F3. Compared with the control group, 15 and 45 differentially hypermethylated genes were identified in the groups administered 5 mg/kg and 500 mg/kg DEHP, respectively. Moreover, 130 and 6 differentially hypomethylated genes were observed in the groups administered 5 mg/kg and 500 mg/kg DEHP. Overall, these results demonstrated that prenatal exposure to DEHP caused transgenerational epigenetic effects, which may explain the observed phenotypic changes in the male reproductive system. 相似文献
2.
This article presents a new method for pairing devices securely. The commitment-based authentication uses a fuzzy secret that the devices only know approximately. Its novel feature is time-based opening of commitments in a single round. We also introduce a new source for the fuzzy secret: synchronized drawing with two fingers of the same hand on two touch screens or surfaces. The drawings are encoded as strings and compared with an edit-distance metric. A prototype implementation of this surprisingly simple and natural pairing mechanism shows that it accurately differentiates between true positives and man-in-the-middle attackers. 相似文献
3.
We present an optimization-based unsupervised approach to automatic document summarization. In the proposed approach, text summarization is modeled as a Boolean programming problem. This model generally attempts to optimize three properties, namely, (1) relevance: summary should contain informative textual units that are relevant to the user; (2) redundancy: summaries should not contain multiple textual units that convey the same information; and (3) length: summary is bounded in length. The approach proposed in this paper is applicable to both tasks: single- and multi-document summarization. In both tasks, documents are split into sentences in preprocessing. We select some salient sentences from document(s) to generate a summary. Finally, the summary is generated by threading all the selected sentences in the order that they appear in the original document(s). We implemented our model on multi-document summarization task. When comparing our methods to several existing summarization methods on an open DUC2005 and DUC2007 data sets, we found that our method improves the summarization results significantly. This is because, first, when extracting summary sentences, this method not only focuses on the relevance scores of sentences to the whole sentence collection, but also the topic representative of sentences. Second, when generating a summary, this method also deals with the problem of repetition of information. The methods were evaluated using ROUGE-1, ROUGE-2 and ROUGE-SU4 metrics. In this paper, we also demonstrate that the summarization result depends on the similarity measure. Results of the experiment showed that combination of symmetric and asymmetric similarity measures yields better result than their use separately. 相似文献
4.
In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria
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Su Chul Jang Sae Rom Kim Yae Jin Yoon Kyong‐Su Park Ji Hyun Kim Jaewook Lee Oh Youn Kim Eun‐Jeong Choi Dae‐Kyum Kim Dong‐Sic Choi Yoon‐Keun Kim Jaesung Park Dolores Di Vizio Yong Song Gho 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(4):456-461
Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo. 相似文献
5.
Reducing the complexity of distance measurement methods for circular turbo codes that use structured interleavers
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Youssouf Ould‐Cheikh‐Mouhamedou 《International Journal of Communication Systems》2015,28(9):1572-1579
The knowledge of turbo code's minimum Hamming distance (dmin) and its corresponding codeword multiplicity (Amin) is of a great importance because the error correction capability of a code is strongly tied to the values of dmin and Amin. Unfortunately, the computational complexity associated with the search for dmin and Amin can be very high, especially for a turbo code that has high dmin value. This paper introduces some useful properties of turbo codes that use structured interleavers together with circular encoding. These properties allow for a significant reduction of search space and thus reduce significantly the computational complexity associated with the determination of dmin and Amin values. © 2014 The Authors. International Journal of Communication Systems published by John Wiley & Sons, Ltd. 相似文献
6.
Based on the multi-item Food Choice Questionnaire (FCQ) originally developed by Steptoe and colleagues (1995), the current study developed a single-item FCQ that provides an acceptable balance between practical needs and psychometric concerns. Studies 1 (N = 1851) and 2 (2a (N = 3290), 2b (N = 4723), 2c (N = 270)) showed that the single-item FCQ scale has good convergent and discriminant validity. Generally, the results showed the highest correlations with the related multi-item dimensions (>0.40). Study 2 refined the scale. Only the items for convenience (Study 2a), sensory appeal (Study 2b) and mood (Study 2c) needed to be revised (as Study 1 showed a correlation between the multi-item and the single-item below the threshold of 0.60). The results also showed comparable predictive validity. Both methods revealed similar association patterns between food motives and consumption behaviours (Fisher’s z tests revealed agreements of 86.2% for Study 1, 92.9% for Study 2a and 100% for Studies 2b and 2c). Study 3 (N = 6062) showed an example of the added value of a context-specific application for the single-item FCQ. Different motives were shown to be relevant across contexts, and the context-specific motives had additional explained variance beyond the general multi-item FCQ. Studies 2b and 3 also showed the performance of the single-item FCQ in an international context. In sum, the results indicate that the single-item FCQ can be used as a flexible and short substitute for the multi-item FCQ. The study also discusses the conditions that should be considered when using the single-item scale. 相似文献
7.
Clustering is a solution for classifying enormous data when there is not any early knowledge about classes. With emerging new concepts like cloud computing and big data and their vast applications in recent years, research works have been increased on unsupervised solutions like clustering algorithms to extract knowledge from this avalanche of data. Clustering time-series data has been used in diverse scientific areas to discover patterns which empower data analysts to extract valuable information from complex and massive datasets. In case of huge datasets, using supervised classification solutions is almost impossible, while clustering can solve this problem using un-supervised approaches. In this research work, the focus is on time-series data, which is one of the popular data types in clustering problems and is broadly used from gene expression data in biology to stock market analysis in finance. This review will expose four main components of time-series clustering and is aimed to represent an updated investigation on the trend of improvements in efficiency, quality and complexity of clustering time-series approaches during the last decade and enlighten new paths for future works. 相似文献
8.
9.
为了满足市场的需要,中石化天津分公司炼油厂根据FCCU自身特点采取了一系列提高柴汽比的措施,包括:调节反应系统和分馏的操作条件及采用MGD技术,以提高柴油产率。实施后,FCCU的柴汽比从0.5提高到0.9,创造了良好的经济效益。 相似文献
10.
随着计算机网络技术的发展,远程教学系统的结构发生了重大的变化,逐步由原来的客户机/服务器(C/S)结构转变为基于Internet的浏览器/服务器(B/S)结构。本文提出了基于CORBA技术的B/S结构系统模型。分析了其运行过程,并与传统的结构进行了比较,指明了其优越性。在本文的结尾。指出了使用这种技术的一个具体例子。 相似文献