Surface functionalization of bioactive glasses and hydroxyapatite with polyphenols from organic red grape pomace |
| |
| Authors: | Giacomo Riccucci Martina Cazzola Sara Ferraris Virginia Alessandra Gobbo Marta Miola Antonella Bosso Gissur Örlygsson Chuen How Ng Enrica Verné Silvia Spriano |
| |
| Affiliation: | 1. Politecnico di Torino, Turin, Italy;2. Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria—Centro di Ricerca Viticoltura ed Enologia, Asti, Italy;3. Innovation Center Iceland, Reykjavík, Iceland;4. Genis hf, Siglufjördur, Iceland |
| |
| Abstract: | An extract of polyphenols was obtained from organic red grape pomace, chemically analyzed, and used for functionalization of two bioactive glasses and porous hydroxyapatite. Functionalization is effective on hydroxyapatite and the bioactive glass with higher surface reactivity with a different grafting mechanism. Grafting does not inhibit redox and radical scavenging activity of polyphenols. The grafted polyphenols make a continuous layer with an almost complete surface coverage. Polyphenols are released with different kinetics according to the mechanism of grafting and maintain their redox activity. A homogeneous thin layer of polyphenols is still firmly grafted on both substrates after 28 days of soaking and it still maintains radical scavenging activity. The functionalized samples can be sterilized by gamma irradiation. |
| |
| Keywords: | bioactive glass hydroxyapatite polyphenols surface modification |
|
|
