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丹皮酚衍生物抗氧化活性研究 总被引:1,自引:0,他引:1
以丹皮酚和有机胺以及多种金属化合物为主要原料,合成11种丹皮酚衍生物。通过DPPH.分析法,研究了目标产物的抗氧化性。结果表明,目标产物有一定抗氧化活性,但清除自由基能力都比较弱。 相似文献
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罗地亚(Rhodia)将投资3500万美元,在上海附近建设一套联苯酚装置,产能1.2万t/a.2007年初建成。新装置将生产联苯酚、邻苯二酚和氢化醌。罗地亚在上海有三座工厂,生产联苯酚衍生物。在无锡与日本宇部合资生产邻苯二酚衍生物邻甲氧基苯酚及香精和香料组分异冰片基环己醇(IBCH)。 相似文献
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<正> 一、引言邻二烷氧基苯或称邻苯二酚醚类是一类有用的合成中间体,可用于天然产物、香料、药物、液晶的合成以及橡胶抗氧剂、高分子聚合终止剂、钻井泥浆稳定剂等制造。近年来发展的一类喹啉型抗球虫饲料添加剂如保喹乐(Buquinolate)、敌可昆(Decoquinate)等均是邻苯二酚醚类的衍生物。因此研究其合成方法,在当前具有相当重要的意义。制取邻苯二酚醚类通常以邻苯二酚为原 相似文献
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邻苯二酚俗称几茶酚或焦尔茶酚,它以多种衍生物的形式存在于自然界中,是重要的精细化工原料,广泛应用于农药、医药、香料、染料、感光材料及橡胶等行业。 一、生产工艺 邻苯二酚的合成工艺很多,目前国内外工业生产所采用的方法主要有以下三种。 相似文献
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对龙眼核中的总黄酮含量和抗氧化性进行了研究,结果表明,龙眼核中黄酮类物质质量分数为1.21%;龙眼核中黄酮类物质对清除自由基有明显作用,且黄酮类物质的添加量在试验范围内与其抗氧化性呈正相关。 相似文献
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以L-谷氨酸为起始原料,经邻苯二甲酸酐保护、酰化开环、肼解脱保护等反应合成了7种茶氨酸类似物,结构经EA、IR、1HNMR、13CNMR和MS进行了确认,并测定了其清除DPPH自由基和羟自由基活性。结果表明:2-氨基-5-氧代-5-[(4-羟基苯基)氨基]戊酸清除自由基活性最强,0.002 mol/L时清除DPPH自由基率为90%,0.004 mol/L时清除羟自由基率达95%;2-氨基-5-氧代-5-[(4-氨基苯基)氨基]戊酸次之。由此可见,茶氨酸类似物中5位连有苯基或所连苯基对位有供电子基团时,可提高其清除DPPH自由基和羟自由基活性,且随对位所连基团供电性的提高,清除活性增强。 相似文献
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以Fenton反应产生羟自由基,测定中华猕猴桃水提液清除羟自由基的能力。以L-酪氨酸和L-多巴为底物,测定中华猕猴桃水提液对酪氨酸酶单酚酶和二酚酶活力的影响以及抑制动力学。实验结果表明:中华猕猴桃水提液对羟自由基有较好的清除作用,当水提液质量浓度为1.0 g/L时,羟自由基清除率达到了95.57%。中华猕猴桃水提液对酪氨酸酶单酚酶和二酚酶的活性均有较好的抑制作用,其半数抑制浓度(IC_(50))分别为0.28和0.35 g/L。动力学研究表明,中华猕猴桃水提液对酪氨酸酶二酚酶的抑制作用属于可逆过程,其抑制作用表现为混合型抑制。 相似文献
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Wei-Cai Zeng Wen-Chang Zhang Wen-Hua Zhang Bi Shi 《Reactive and Functional Polymers》2013,73(3):573-578
The antioxidant activity and food protection effect of bioactive polypeptides from bovine hair were investigated. In various in vitro tests, polypeptides showed a strong reducing power and a remarkable antioxidant capability to scavenge free radicals (ABTS, superoxide and hydroxyl radicals). Moreover, polypeptides also exhibited a significant food protection effect to inhibit the oxidation of edible oil by controlling the peroxide value (POV). Furthermore, by using gel filtration chromatography (GFC), high performance size exclusion chromatography (HPSEC), amino acid analysis and atomic force microscopy (AFM), an antioxidant polypeptide (APB) was purified and characterized with a molecular weight of 18.7 KDa in the form of spherical lumps, which was composed of 17 kinds of amino acids and contained sulfydryl group. Our results suggested that the antioxidant polypeptide from bovine hair could be a new potential source for preparing natural antioxidant applied in oil or oil-rich food. 相似文献
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为了从吡嗪和噁唑类化合物中寻找新的抗氧化剂,本文采用FeCl3催化吡嗪-N-氧化物和噁唑化合物发生氧化偶联反应,合成了3个吡嗪-噁唑联芳类化合物。采用1HNMR、13CNMR和MS对目标化合物的结构进行了表征;通过抑制自由基引发的DNA氧化反应及淬灭自由基反应体系对化合物的抗氧化活性和还原能力进行了测试。结果表明,3个目标化合物能够有效地抑制自由基引发的DNA氧化反应并捕获自由基,具有较强的自由基清除能力和还原能力,是一类潜在的抗氧化剂。其中,在抑制2,2''-偶氮二异丁基脒二盐酸盐(AAPH)引发的DNA氧化反应体系中,3个吡嗪-噁唑联芳类化合物的有效计量因子(n)分别为1.48、1.78和1.88; 在抑制HO?和还原型谷胱甘肽自由基(GS?)引发的DNA氧化反应体系中,3个化合物相对空白硫代巴比妥酸活性物质(TBARS)吸光度百分数分别为76.1%和68.3%、69.8%和64.1%及72.6%和67.4%;3个化合物均能够捕获2,2''-偶氮-双-(3-乙基苯并噁唑啉-6-磺酸)二铵盐自由基(ABTS ?)和二苯苦味酰肼自由基(DPPH?)。 相似文献
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葛根素的基础研究与临床应用新进展 总被引:10,自引:0,他引:10
葛根素是中药葛根的主要有效成分之一。实验证明有清除氧自由基,抗氧化性损伤,扩张心脑血管和降低心肌氧耗等多种作用,临床主要用于防治心脑血管疾病。本文就近年来葛根素的药理学及其临床应用的最新进展进行了综述。 相似文献
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A chemical reduction method for preparing monodispersed pure-phase copper colloids in water and ethylene glycol has been reported.
Owing to the reduction property of ethylene glycol, the reaction rate in ethylene glycol is higher than that in water. In
addition, the amount of reducing agent can be reduced largely. Ascorbic acid plays roles as reducing agent and antioxidant
of colloidal copper, due to its ability to scavenge free radicals and reactive oxygen molecules. Thermogravimetric results
reveal that the as-prepared copper nanoparticles have good stability, and they begin to be oxidized at above 210 °C. Polyvinyl
pyrrolidone works both as size controller and polymeric capping agents, because it hinders the nuclei from aggregation through
the polar groups, which strongly absorb the copper particles on the surface with coordination bonds. 相似文献
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Nadhir Gourine Mohamed Yousfi Isabelle Bombarda Boubakeur Nadjemi Emile Gaydou 《Journal of the American Oil Chemists' Society》2010,87(2):157-166
The composition and antioxidant activities of Pistacia atlantica Desf. essential oil were investigated. Qualitative and quantitative differences in compositions and in antioxidant activities
of male and female leaf essential oils were observed during the season. The essential oils obtained by hydrodistillation were
analysed by GC and GC–MS. The oils were rich in monoterpenes hydrocarbons and oxygenated sesquiterpenes. The main components
of male essential oil were α-pinene/α-thujene, spathulenol and bicyclogermacrene. The major component of female essential oil was δ-3-carene. The seasonal variation showed that most of the main components of the oils reached theirs highest values in September.
The antioxidant activity of the oil was investigated in vitro using two assays: DPPH· (2,2-di-phenyl-1-picrylhydrazyl) free radical-scavenging and FRAP (Ferric Reducing Antioxidant Power). The highest antioxidant
capacity to scavenge free DPPH radicals was reached in the month of June for male oils and during the months of September–October
for the female oils. The high reducing power for male oil was observed during the month of June and for the female oil it
was in August. The female oil was more active than the male oil. The antioxidant capacity of the female oil was almost ten
times higher than Ascorbic acid in the FRAP assay. 相似文献
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The major objective was to measure the trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) equivalent antioxidant
capacity (TEAC) of carbazole derivatives (Ar2NHs) by means of scavenging 2,2′-diphenyl-1-picrylhydrazyl (DPPH) and the 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate)
radical cation (ABTS+·). The Ar2NHs included phenoxazine (PozNH), phenothiazine (PtzNH), iminostilbene (IsbNH) and diphenylamine (DpaNH), and the TEAC of
trolox, α-tocopherol (TocH), l-ascorbic acid (VC) and l-ascorbyl-6-laurate (VC-12) were measured as well. The TEAC results revealed that the ability to scavenge DPPH (PozNH > IsbNH ~PtzNH ~TroH ~TocH ~VC ~VC12),
differed from the ability to scavenge ABTS+ (PtzNH > IsbNH > PozNH > DpaNH ~TroH ~TocH ~VC ~VC12). CazNH did not react with DPPH and ABTS+·. Furthermore, the addition of acetic acid accelerated the reaction rate of Ar2NH to scavenge DPPH, suggesting that a sequential proton loss electron transfer (SPLET) mechanism occurred with amine-type
antioxidants during the trapping of DPPH. In contrast, the addition of acetic acid or pyridine reduced the reaction rate of
Ar2NH to scavenge ABTS+., suggesting that the hydrogen atom transfer (HAT) mechanism is the basis for the reaction that is occurring.
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