一种重叠胃腺癌细胞分离线估计算法

针对胃腺癌细胞显微图像中经常出现重叠(或粘连)现象,对后续进一步的研究工作产生了很多不良影响,为了准确地分离重叠(或粘连)的胃腺癌细胞,采用了一种数学形态学与改进的B样条活动轮廓模型算法相结合的方法。该算法首先对图像进行二值化处理,然后利用变元腐蚀得到细胞的非线性距离图和背景的非线性距离图,接着对两者进行叠加,即得到一幅新的非线性距离图,最后使B样条曲线准确收敛到目标边界,以便自动分离细胞。实验结果表明,该算法不但能有效地构造分离线,并能估计出重叠(或粘连)胃腺癌细胞的原始形状。     

基于形态学和活动轮廓模型的活体细胞图像分割算法

针对常用细胞轮廓分割方法人工干预较多的缺点，提出基于形态学和活动轮廓模型的活体细胞图像分割算法．利用形态学的基本操作提取活体细胞的初始轮廓，运用活动轮廓模型提取准确的细胞轮廓．实验表明该算法鲁棒性和准确性较好，能在无人工干预的情况下获取准确的细胞边缘．     

重叠细胞图像分离算法的设计

在实际的细胞图像中,经常会遇到重叠现象（又称为聚堆）,即多个细胞聚一起的情形,这给后续的分析处理带来了困难,因此需要设计一个有效的算法,能够将这些重叠在一起的细胞群分离为单个的细胞,文中针对二值化的图像,提出了一个基于形态学的算法,该方法首先利用腐蚀操作,以确定聚堆细胞最终分离为单个细胞的个数,然后再根据腐蚀后的结果,在原妈的二值图像上找到了分离点,从而最终有效地将重叠细胞分离为单个细胞,文中主要     

活动轮廓模型在重叠藻细胞计数中的应用

针对重叠藻细胞显微图像的计数问题,提出一种基于活动轮廓模型的重叠藻细胞自动计数方法。对重叠藻细胞显微图像进行预处理,标记连通域,提取并处理局部图像,采用活动轮廓模型算法提取重叠藻细胞边缘,同时进行边缘分析和计数。与传统分水岭算法相比,该计数方法不直接进行重叠藻细胞分割,可以消除因直接分割时过分割与欠分割导致的计数误差,提高重叠藻细胞计算准确度。实验结果表明,该方法对重叠藻细胞的计数准确率高于90%。     

基于稀疏轮廓点模型的彩色重叠细胞图像分割

根据对细胞轮廓结构的分析,提出了描述细胞轮廓特征的稀疏轮廓点模型。该模型将细胞轮廓划分为强轮廓和弱轮廓2部分,并用一系列稀疏的轮廓点来近似表示细胞轮廓。在该模型的基础上,算法综合了彩色图像处理与灰度图像处理的方法,首先提取细胞与背景交界处的强轮廓作为基准轮廓。然后提出了一种环形动态轮廓搜索算法,沿着基准轮廓搜索位于重叠细胞区域的弱轮廓。经过轮廓搜索算法获得细胞的稀疏轮廓点组成初始轮廓,采用 GVF（gradient vector flow ） Snake 模型进行细胞的精确分割。通过对2个细胞图像数据集的图像样本进行的分割实验验证了算法对于分割单细胞图像、同种颜色重叠细胞图像和不同颜色重叠细胞图像的准确性。     

一种改进的重叠细胞分离算法

在细胞图像识别中,经常会遇到细胞重叠的现象,需要有一种有效的方法将重叠在一起的细胞分离成单个的细胞。目前很多分离算法都是基于数学形态学的,但这些算法都存在着一定的局限性。为此,提出了一种改进的基于数学形态学的分离算法,该算法首先采用一种简单、快速的边界剥离方法得到距离变换结果,然后再用分水岭方法对细胞图像进行分离。实验结果表明,算法获得了较好的分离效果。     

结合数学形态学和无边界主动轮廓模型的图像分割方法

为了改善主动轮廓模型的效率,并扩大其适用范围,提出了一种将数学形态学和无边界主动轮廓模型相结合的图像分割方法,先利用数学形态学的平滑算子ASF进行预处理,再利用无边界主动轮廓模型分割平滑图像.试验分析表明,该方法不仅能够提高分割的精确度,还可以减少迭代次数,从而使得主动轮廓模型可以应用到一些背景比较复杂的图像分割中.     

基于主凹点检测的血细胞图像去粘连分割算法研究

针对医学中血细胞图像研究中粘连细胞难以分割的问题,提出一种基于主凹点检测的分割算法。通过滤波预处理去除图像的噪声以改善图像质量,基于改进的活动轮廓模型初步提取细胞轮廓,通过寻找主凹点的方法准确定位粘连细胞凹点位置,标记并融合细胞图像轮廓、粘连形状等特性,实现粘连细胞分离。实验结果表明,该方法具有很好的分割准确度和完整度,且该算法具有普适性。     

一种新的几何活动轮廓模型在图像分割中的应用

针对传统几何活动轮廓模型不能准确分割图像内弱边界区域目标以及对噪声的干扰容易使曲线陷入局部极值的情况,提出了一种基于区域梯度流力的几何活动轮廓模型.由于该区域力是对图像进行区域分割后产生的,所以能够从全局的角度为模型提供区域内目标的边界信息,进而达到分割弱边界的目的.通过引入一个扩散方程可以扩大区域力的捕捉范围,达到消除噪声干扰的目的.实验证明,该模型较好地解决了传统活动轮廓模型分割图像目标存在的问题.     

基于异常检测的尿沉渣图像分割

在尿沉渣图像中,由于其样本特性,使得在细胞图像采集时会有大量的杂质。这些杂质形状不规则,颜色不单一,用传统的图像分割算法难以去除。针对这个问题,提出一种基于异常检测的图像分割算法。该方法用形态学的方法对二值图像进行轮廓提取,根据其轮廓进行特征提取并且进行标记,然后用提取的轮廓特征以及标记构建异常检测模型。最终根据该模型对图象进行分割,并且定量地对该模型进行评价。实验结果表明,基于异常检测模型的尿沉渣检测方法能够以较高精度将杂质从细胞图像中分离。     

煤矿井下安全监控分站的设计及其仿真实现

为了设计一种具有低成本、低功耗、易操作、功能强且可靠性高的煤矿井下安全分站,针对煤矿安全生产实际,文章提出了采用MCS-51系列单片机为核心、具有CAN总线通信接口的煤矿井下安全监控分站的设计方案;首先给出煤矿井下安全监控分站的整体构架设计,然后着重阐述模拟量输入信号处理系统的设计过程,最后说明单片机最小系统及其键盘、显示、报警、通信等各个组成部分的设计;为验证设计方案的可行性与有效性,使用Proteus软件对设计内容进行仿真验证,设计的煤矿井下安全监控分站具有瓦斯、温度等模拟量参数超标报警功能和电机开停、风门开闭等开关量指示功能;仿真结果表明:设计的煤矿井下安全监控分站具有一定的实际应用价值.     

View-based model-driven architecture for enhancing maintainability of data access services

In modern service-oriented architectures, database access is done by a special type of services, the so-called data access services (DAS). Though, particularly in data-intensive applications, using and developing DAS are very common today, the link between the DAS and their implementation, e.g. a layer of data access objects (DAOs) encapsulating the database queries, still is not sufficiently elaborated, yet. As a result, as the number of DAS grows, finding the desired DAS for reuse and/or associated documentation can become an impossible task. In this paper we focus on bridging this gap between the DAS and their implementation by presenting a view-based, model-driven data access architecture (VMDA) managing models of the DAS, DAOs and database queries in a queryable manner. Our models support tailored views of different stakeholders and are scalable with all types of DAS implementations. In this paper we show that our view-based and model driven architecture approach can enhance software development productivity and maintainability by improving DAS documentation. Moreover, our VMDA opens a wide range of applications such as evaluating DAS usage for DAS performance optimization. Furthermore, we provide tool support and illustrate the applicability of our VMDA in a large-scale case study. Finally, we quantitatively prove that our approach performs with acceptable response times.     

A pragmatic multi-method investigation of discrepant technological events: Coping,attributions, and ‘accidental’ learning

Discrepant technological events or situations that entail a problem, a misunderstanding or a difficulty with the Information Technology (IT) being employed, are common in the workplace, and can lead to frustration and avoidance behaviors. Little is known, however, about how individuals cope with these events. This paper examines these events by using a multi-method pragmatic approach informed by coping theory. The results of two studies – a critical incident study and an experiment – serve to build and test, respectively, a theoretical model that posits that individuals use a variety of strategies when dealing with these events: they experience negative emotions, make external attributions, and adopt engagement coping strategies directed at solving the event, eventually switching to a disengagement coping strategy when they feel they have no control over the situation. Furthermore, users’ efforts may result in ‘accidental’ learning as they try to overcome the discrepant IT events through engagement coping. The paper ends with a discussion of the results in light of existing literature, future opportunities for research, and implications for practice.     

The Distributed Time-Triggered Simulation Scheme: Core Principles and Supporting Execution Engine

Distributed real-time simulation is a young technology field but its practice is under increasing demands. In recent years the author and his collaborators have been establishing a new approach called the distributed time-triggered simulation (DTS) scheme which is conceptually simple and easy to use but widely applicable. The concept was initiated in the course of developing a new-generation object-oriented real-time programming scheme called the time-triggered message-triggered object (TMO) programming scheme. Some fundamental issues inherent in distributed real-time simulation that were learned during recent experimental studies are discussed along with some approaches for resolving the issues. An execution engine developed to support both the TMOs engaged in control computation and the TMOs engaged in DTS is also discussed along with its possible extensions that will enable significantly larger-scale DTSs.     

Software-Konfigurationsmanagement in großen Softwareprojekten

Zusammenfassung Mit zunehmender Größe der Softwaresysteme verschärfen sich die für die Software-Herstellung typischen Probleme: Beherrschen großer Objektmengen, Erhalten der Systemkonsistenz, Kontrolle der ständigen Änderungseinflüsse und Gewährleisten einer langen Lebensdauer. Die Disziplin Konfigurationsmanagement bildet den methodischen Ansatz, diese Probleme besser zu beherrschen. Software-Konfigurationsmanagement faßt die Herstellung von Softwaresystemen als eine Abfolge von kontrollierten Änderungen an gesicherten Zwischen- und Endergebnissen auf. Dargestellt werden die Objekte und Funktionen des Software-Konfigurationsmanagements sowie die hierfür in großen Software-Projekten benötigten Methoden, Instanzen und Hilfsmittel.     

Information for Authors

正http://www.zju.edu.cn/jzus http://www.springerlink.com Aim The Journals of Zhejiang University-SCIENCE(A/B/C)are edited by the international board of distinguished Chinese and foreign scientists,and are aimed to present the latest developments and achievements in scientific research in China and     

Editorial:Brain-machine interface(BMI) and cyborg intelligence

正Brain-machine interfaces(BMIs)aim at building a direct communication pathway between the brain and an external device,and represent an area of research where significant progress has been made during the past decade.Based on BMIs,mind information can be read out by neural signals to control     

Information for Authors

正http://www.zju.edu.cn/jzus http://www.springerlink.com Aim The Journals of Zhejiang University-SCIENCE(A/B/C)are edited by the international board of distinguished Chinese and foreign scientists,and are aimed to present the latest developments and achievements in scientific research in China and overseas to the world’s scientific circles,especially to stimulate     

SCIENCE CHINA Information Sciences SUBJECT INDEX TO VOLUME 57(2014)

正~~     

Information for Authors

正http://www.zju.edu.cn/jzus http://www.springerlink.com Aim The Journals of Zhejiang University-SCIENCE(A/B/C)are edited by the international board of distinguished Chinese and foreign scientists,and are aimed to present the latest developments and achievements in scientific research in China and overseas to the world’s scientific circles,especially to stimulate