顺式-甲基丙二酸-二氨合铂(II)的合成、表征及抗癌活性

为合成新的铂配合物顺式-甲基丙二酸-二氨合铂(II),以顺式二碘-二氨合铂(II)为起始原料,先后与硝酸银和甲基丙二酸反应合成目标化合物。采用元素分析、质谱、核磁共振氢谱和红外光谱分析其组成和结构,采用MTT法对配合物进行了初步的体外活性评价。结果显示合成的化合物结构与理论一致,具有一定的体外肿瘤生长抑制活性。     

Cis-[Pt(NH_3)_2(H_2O)_2](NO_3)_2与1,1-环丁烷二羧酸钠形成的一种新的Pt(Ⅱ)配合物(英文)

从Cis-[Pt(NH3)2(H2O)2](NO3)2 与1,1-环丁烷二羧酸钠的化学反应中,分离出一种新的Pt(II)配合物,通过元素分析、红外光谱, 质谱和高效液相色谱的分析测试,初步推测结构为顺式-四氨-μ-二(1,1-环丁烷二羧酸根-O1,O2)合二铂的新化学结构式.     

顺式-水杨酸-(反式-(-)-1,2-环己二胺)合铂(II)的合成、表征及抗肿瘤活性

用顺式-二碘-(反式-(-)-1,2-环己二胺)合铂(Ⅱ)先后与硝酸银和水杨酸反应,制备得到新的铂配合物顺式-水杨酸-(反式-(-)-1,2-环己二胺)合铂(Ⅱ)。采用元素分析、质谱、核磁共振氢谱和红外光谱等方法分析了其组成和结构,采用SRB比色法对配合物进行了初步体外活性评价。结果显示合成的化合物结构与理论一致,化合物对肺癌细胞株(A549)和口腔表皮样癌细胞株(KB)的IC50值分别为2.3和3.1μg/mL。     

顺式-没食子酸-氨,2-甲基吡啶合铂(Ⅱ)的合成、表征及抗肿瘤活性

为合成新的铂配合物顺式-没食子酸-氨,2-甲基吡啶合铂(Ⅱ),以氯亚铂酸钾为起始原料,先后与碘化钾、2-甲基吡啶、氨水、硝酸银和没食子酸反应合成目标化合物。采用元素分析、质谱、核磁共振氢谱和红外光谱分析其组成和结构,利用MTT体外检测法进行了初步的体外活性评价。结果显示合成的化合物结构与理论值一致,具有一定的体外肿瘤生长抑制活性。     

顺式-碘氯[(1R,2R)-(-)-1,2-环己二胺]合铂(Ⅱ)的合成及结构表征

为了合成新型铂抗癌药物米铂的代谢产物之一顺式-碘氯[(1R,2R)-(-)-1,2-环己二胺]合铂(Ⅱ),以K2PtCl4为起始原料先后与二甲基亚砜、(1R,2R)-(-)-1,2-环己二胺、AgNO3、KI和KCl反应合成目标化合物。采用元素分析、质谱、核磁共振氢谱、红外光谱和热分析方法分析其组成和结构,结果显示合成的化合物结构与标题化合物一致。     

((R)-(-)-1,2-丙二胺)(1,3-丙二酸)合铂(II)的合成、表征及抗肿瘤活性研究

以1,2-丙二胺为起始原料,经手性拆分得到R-(-)-1,2-丙二胺,再同氯亚铂酸钾、碘化钾、硝酸银、1,3-丙二酸钠等物质反应,制成((R)-(-)-1,2-丙二胺)(1,3-丙二酸)合铂(II),通过元素分析、红外光谱、核磁共振等对其进行化恘结构确证,结果表明所合成产品同理论一致,并进行初步体外活性评价,表明该化合物对于肺癌A-549及白血病HL-60肿瘤细胞有一定活性。     

Cis-[Pt（NH3）2（H2O）2]（NO3）2与1，1-环丁烷二羧酸钠形成的一种新的Pt（II）配合物

从Cis-[Pt（NH3）2（H2O）2]（NO3）2与1,1-环丁烷二羧酸钠的化学反应中,分离出一种新的Pt（II）配合物,通过元素分析、红外光谱,质谱和高效液相色谱的分析测试,初步推测结构为顺式-四氨-μ-二（1,1-环丁烷二羧酸根-O^1,O^2）合二铂的新化学结构式。     

顺式-乙二酸-(反式-1,2-二甲胺基环丁烷)合铂(Ⅱ)的合成、表征及抗肿瘤活性

设计并合成了一种洛铂衍生物顺式-乙二酸-(反式-1,2-二甲胺基环丁烷)合铂(Ⅱ)(C8H14O4N2Pt)。采用元素分析、质谱(ESI-MS)、红外光谱(IR)、核磁共振氢谱(1H NMR)对其化学组成和结构进行了确认和表征,用高效液相色谱(HPLC)测定其在水溶液中的稳定性,并用MTS法对其进行抗肿瘤活性评价。结果表明化合物结构与理论一致,在水溶液中比较稳定,对5种常见肿瘤细胞具有明显的抑制作用。     

双(二叔丁基苯基膦)二卤化Pt(Ⅱ)配合物的合成及结构测试

采用铂替代钯合成了以二叔丁基苯基膦[(t-Bu)_2PPh]和卤素(Cl、Br)为配体的Pt(Ⅱ)配合物。以氯化铂(PtCl_2)和溴化铂(PtBr_2)为起始原料,二甲亚砜(DMSO)为溶剂,在氮气保护下与二叔丁基苯基膦反应,得到目标化合物。结果表明,Pt[(t-Bu)_2PPh]_2Cl_2产率为96.9%,Pt[(t-Bu)_2PPh]_2Br_2产率为94.1%,2种化合物的纯度均大于99%。通过元素分析、核磁共振(~1H-NMR)分析和单晶X射线衍射(XRD)分析测定了目标化合物的化学结构,结果显示,配合物均为trans-四配位的平面正方形配合物,Pt(Ⅱ)处于配位平面的中心,分别与2个Cl或者Br和P键合,形成4配位的平面四边形的结构,2个卤素原子和膦配体处于反位。     

离子交换法制备铂(II)和钯(II)的硝酸四氨络合物及结构表征

采用一种全新的方法—离子交换法,以二氯四氨合铂(II)和二氯四氨合钯(II)为原料,水为溶剂,制备铂、钯的重要催化前驱体化合物—硝酸四氨合铂(II)和硝酸四氨合钯(II)。通过元素分析、红外光谱、质谱、核磁共振表征其化学结构。方法的产率＞90%,产品纯度＞99.0%(以金属铂、钯计),适合于批量生产要求。     

The corrosion of steel and aluminium in calcium chloride/ammonia,magnesium chloride/methylamine and magnesium chloride/methylamine/decane

The corrosion of St 37, StE 36, Al 99,5 and Al-Mg 3 in the chemical pairs of substances calcium chloride/ammonia, magnesium chloride/methylamine and magnesium chloride/methylamine/decane was investigated. The corrosion tests were performed in autoclaves at room temperature to 180 °C. The nominal duration of the experiments was 1000 hours. Rod shaped fatigue specimens with polished surfaces served as test specimens; these were fatigue tested after the corrosion treatments. All materials tested were compatible with calcium chloride/ammonia under the experimental conditions employed. Steel and aluminium showed similar behaviour against magnesium chloride/methylamine and magnesiumchloride/methylamine/decane, respectively. At room temperature and 70°C to 80°C the corrosion of steel and aluminium was low (wall losses in the order of 1 m?m/a). Corrosion increased with increasing temperature. The activation energy for the reaction, which determined the rate of weight loss in magnesium chloride/methylamine/decane, was AE_st = 0, 60 ± 0,18 eV for steel, and AE_Al = 1, 07 ± 0,07 eV for aluminium. A corrosion treatment on aluminum fatigue specimens after 1000-1500 hours at 110 °C caused a notable decrease in fatigue strength; no such behaviour was noted for steel, even when corroded at 170 °C.     

Chromium base high performance materials: Where and how do they come from?

The origin of chromium base performance materials (CBPM) is described. CBPM may include (1) trivalent chromium chemicals such as chromic acetate, chromic chloride, chromic bromide, chromic fluoride, chromic iodide, chromic phosphate, and chromic sulfate; (2) hexavalent chromium chemicals such as chromic acid, lithium chromate, sodium chromate, sodium dichromate, and potassium dichromate; (3) oxide forms of chromium such as black chrome, chromium dioxide, chromium oxide, and chromium hydroxide; and (4) other chromium compounds such as chromium aluminide, chromium boride, chromium carbide, chromium molybdate, chromium nitride, chromium silicide, chromium tungstate and lanthanum chromite. Extensive reviews of production processes, properties, and applications/end uses of CBPM are made.     

铁矿粉烧结电除尘灰中氯化钾的赋存形态及其水浸动力学分析

为分析氯化钾从烧结电除尘灰中水浸出速率及浸出动力学,使用扫描电镜-线扫描分析氯化钾在烧结电除尘灰中的赋存状态及其与其它颗粒之间的赋存关系。实验发现烧结电除尘的平均粒径小于10μm,大多以团聚形式存在;氯化钾和氯化钠颗粒在烧结电除尘中的部分表面与其它粉尘颗粒如铁氧化物、钙镁化合物等有粘附连接。氯化钾在烧结电除尘中的存在形式表明其水浸出过程可视为可溶水的物质的溶解过程。借助于在线电导率测量手段分析烧结电除尘灰的水浸动力学。结果证明该粉尘的水浸过程符合扩散控制的溶解过程模型。浸出平衡在5min之内即可达到,同时氯化钾的浸出率达到 95%以上。     

Experimental and theoretical structural analysis of Zn(II)‐1‐hydroxyethane‐1,1‐diphosphonic acid corrosion inhibitor films in chloride ions solution

This work aims to analyze, through weight loss and X‐ray photoelectron spectroscopy (XPS) methods, the inhibitive films of 1‐hydroxyethane‐1,1‐diphosphonic acid (1‐hydroxyethylidene‐1,1‐diphosphonic acid, HEDP) and zinc(II) ions formed on AISI 1020 carbon steel when immersed in solutions containing 30 ppm of chloride ions, 50 ppm of HEDP, and three different concentrations of zinc(II) ions (14, 20, and 30 ppm). Moreover, the results of the experimental surface analyses were compared to molecular modeling studies of the proposed HEDP–Fe(III)/Zn(OH)₂/HEDP–Zn(II) protective film. The film presented dissimilar structures responsible for the different levels of metallic protection for each particular zinc(II) concentration. In general, the increase in Zn(II) concentration leads to more compact and adherent film formation, with decreased corrosion rates of carbon steel.     

系列金(I)有机膦化合物的合成

以氯金(III)酸(HAuCl4)为起始原料,经过两步反应合成了3种有机膦氯化金化合物,产率均在95%以上。首先HAuCl4与二甲基硫醚(Me2S)反应,制备二甲基硫醚氯化金(I)中间体;然后与有机膦,包括三苯基磷(PPh3)、双(二苯基膦)二茂铁(dppf)、1,2-双(二苯基膦)乙烷(dppe)反应,合成了的三苯基膦氯化金(I)[AuCl(PPh3)]等有机膦氯化金,[AuCl(PPh3)]与三氟甲烷磺酸银(AgSO3CF3)反应,可进一步获得三氟甲烷磺酸三苯基膦金(I)[(CF3SO3)][Au(PPh3)]。     

Isophorone-based analogues with A-π-D-π-A structure for red organic light emitting devices

New electroluminescent materials, two DCM analogues 1,4-Bis[2-[3-(1,1-dicyan ovinyl)-5,5-dimethyl-cyclohexeneyl]vinyl]benzene (1) and 1,4-Bis{2-[3-(1,1-dicya novinyl)-5,5-dimethyl-cyclohexeneyl]vinyl}-2,5-di-(n-butoxy)benzene (2) with A-π-D-π-A structure were synthesized and characterized. Optical properties (UV–vis and fluorescence) were studied for both compounds according to the spectra analysis. Theoretical calculation and cyclic voltammetry were used to analyzed the frontier molecular orbital of the two compounds. The result suggest that compound 2 can used not only as dopants but also as host emission and electron injection materials. Two kinds of red OLEDs were fabricated using 2 and all the devices achieved good CIE coordinates.     

Potential high temperature corrosion problems due to co‐firing of biomass and fossil fuels

Over the past few years, considerable high temperature corrosion problems have been encountered when firing biomass in power plants due to the high content of potassium chloride in the deposits. Therefore, to combat chloride corrosion problems co‐firing of biomass with a fossil fuel has been undertaken. This results in potassium chloride being converted to potassium sulphate in the combustion chamber and it is sulphate rich deposits that are deposited on the vulnerable metallic surfaces such as high temperature superheaters. Although this removes the problem of chloride corrosion, other corrosion mechanisms appear such as sulphidation and hot corrosion due to sulphate deposits. At Studstrup power plant Unit 4, based on trials with exposure times of 3000 h using 0–20% straw co‐firing with coal, the plant now runs with a fuel mix of 10% straw + coal. Based on results from a 3 years exposure in this environment, the internal sulphidation is much more significant than that revealed in the demonstration project. Avedøre 2 main boiler is fuelled with wood pellets + heavy fuel oil + gas. Some reaction products resulting from the presence of vanadium compounds in the heavy oil were detected, i.e. iron vanadates. However, the most significant corrosion attack was sulphidation attack at the grain boundaries of 18‐8 steel after 3 years exposure. The corrosion mechanisms and corrosion rates are compared with biomass firing and coal firing. Potential corrosion problems due to co‐firing biomass and fossil fuels are discussed.     

Triazole derivatives as corrosion inhibitors for mild steel in hydrochloric acid solution

The title compounds 1-(4,5-dihydro-3-phenyl pyridine-1-yl)-2-(1H-1,2,4-triazole-1-yl)ethyl ketones were studied as a corrosion inhibitor in a mild steel in 1 mol /L hy-drochloric acid solution using weight loss measurement,potentiodynamic polariza-tion,and electrochemical impedance spectroscopy(EIS).Results indicated that these compounds had excellent inhibition properties.Polarization curves indicated that the inhibitor behaved mainly as mixed-type inhibitor.The EIS results showed that the charge transfer ...     

A rotating disk study of gold dissolution by bromine

Gold dissolution with bromine was studied using the rotating disk technique with Geobrom? 3400 as a source of bromine. The parameters studied were speed of rotation, lixiviant concentration, pH, temperature, sulfuric acid and hydrochloric acid concentrations, and the concentrations of various cations (i.e., copper, iron, zinc, aluminum, manganese, potassium, and sodium) and anions (i.e., chloride, bromide, sulfate, nitrate, and iodide). According to the Lavich plot and activation energy, gold dissolution is controlled by a chemical reaction rate. Copper, iron, and manganese in their highest oxidation states, as well as aluminum, zinc, sodium, and potassium, have no effect on the rate of gold dissolution. The presence of manganous ion substantially decreases the gold dissolution rate. The kinetic performance of bromine was found to be dramatically better than the performance of cyanide and thiourea.     

Organic corrosion inhibitors for zinc pigment

Abstract

A severe problem with waterborne paints containing zinc pigments is hydrogen corrosion of the zinc in the aqueous alkaline paint media. The subject of the present study is the examination of corrosion inhibition of the zinc pigment in aqueous alkaline media by different high and low molecular weight organic inhibitors compared with that given by potassium dichromate. Potassium dichromate inhibits this corrosion reaction moderately, but a 4·0 mmol addition in 100 mL of the corrodent (1·2 wt-%) is required. Heterocyclic compounds are very poor corrosion inhibitors and less effective than potassium dichromate. Certain polymers with low acid numbers and low molecular weights and one particular epoxy ester resin are more effective inhibitors than potassium dichromate. Thus, some non-toxic polymers or paint resins can be considered as possible substitutes for toxic potassium dichromate.