Designing amorphous formulations of polyphenols with naringin by spray-drying for enhanced solubility and permeability

Naringin (NAR), a major flavanone (FVA) glycoside, is a component of food mainly obtained from grapefruit. We used NAR as a food additive to improve the solubility and permeability of hydrophobic polyphenols used as supplements in the food industry. The spray-dried particles (SDPs) of NAR alone show an amorphous state with a glass transition temperature (T_g) at 93.2 °C. SDPs of hydrophobic polyphenols, such as flavone (FVO), quercetin (QCT), naringenin (NRG), and resveratrol (RVT) were prepared by adding varying amounts of NAR. All SDPs of hydrophobic polyphenols with added NAR were in an amorphous state with a single T_g, but SDPs of hydrophobic polyphenols without added NAR showed diffraction peaks derived from each crystal. The SDPs with NAR could keep an amorphous state after storage at a high humidity condition for one month, except for SDPs of RVT/NAR. SDPs with NAR enhanced the solubility of hydrophobic polyphenols, especially NRG solubility, which was enhanced more than 9 times compared to NRG crystal. The enhanced solubility resulted in the increased membrane permeability of NRG. The antioxidant effect of the hydrophobic NRG was also enhanced by the synergetic effect of NAR. The findings demonstrated that NAR could be used as a food additive to enhance the solubility and membrane permeability of hydrophobic polyphenols.     

{X,Y}-Cyclacene Graphs with Next Nearest Neighbor Interactions

Eigensolutions of {X( = C,B,N),Y( = C,B,N)}-cyclacene graphs with next nearest neighbor (nnn) interactions have been obtained in analytical forms by adapting n-fold rotational symmetry followed by two-fold rotational symmetry (or a plane of symmetry). Expressions of eigensolution indicate the subspectral relationship among such cyclacenes with an even number of hexagonal rings e.g., eigenvalues of {X,Y}-di-cyclacene are found in the eigenspectra of all such even cyclacenes. Total π-electron energies and highest occupied molecular orbital and lowest unoccupied molecular orbital (HOMO–LUMO) gaps are calculated using the analytical expressions obtained and are found to vary negligibly with the variation of nnn interactions in such cyclacenes. Total π-electron energy is found to increase due to increase in restriction intensity of nnn interactions, whereas the HOMO–LUMO gap of polyacenecs having the even number of hexagonal rings and with one electron at each site (atom) decreases with increase in the restriction intensity since such systems contain degenerate half-filled HOMO (bonding or nonbonding) that are much more vulnerable for perturbations imposed through nnn interactions.     

新型高k栅介质材料研究进展

随着半导体技术的不断发展，MOSFET（metal-oxide-semiconductor field effect transistor）的特征尺寸不断缩小，栅介质等效氧化物厚度已小至nm数量级。这时电子的直接隧穿效应将非常显著，将严重影响器件的稳定性和可靠性。因此需要寻找新型高k介质材料，能够在保持和增大栅极电容的同时，使介质层仍保持足够的物理厚度来限制隧穿效应的影响。本文综述了研究高k栅介质材料的意义；MOS栅介质的要求；主要新型高k栅介质材料的最新研究动态；展望了高k介质材料今后发展的主要趋势和需要解决的问题。     

毛家河水电站库区岩溶发育特征及邻谷渗漏分析

毛家河水电站位于碳酸盐岩地区，库首距左岸邻谷可渡河14—23km、距右岸邻谷北盘江干流14．8km，水库两岸大型落水洞、溶洞及地下岩溶管道相对较为发育。为初步判断水库存在邻谷渗漏的可能性，对水库两岸可溶岩地层岩溶发育形态、特征及规律进行了勘察，并根据现场地质调查资料对3条可疑渗漏带进行了分析论证。     

种分Δαk与种分首槽αk的关系

针对烧结法和拜尔法种分槽的 Δαk 变化进行了概述 ,阐述了种分 Δαk 与种分首槽 αk 的关系。     

Rectilinear steiner tree heuristics and minimum spanning tree algorithms using geographic nearest neighbors

We study the application of the geographic nearest neighbor approach to two problems. The first problem is the construction of an approximately minimum length rectilinear Steiner tree for a set ofn points in the plane. For this problem, we introduce a variation of a subgraph of sizeO(n) used by YaO [31] for constructing minimum spanning trees. Using this subgraph, we improve the running times of the heuristics discussed by Bern [6] fromO(n ² log n) toO(n log² n). The second problem is the construction of a rectilinear minimum spanning tree for a set ofn noncrossing line segments in the plane. We present an optimalO(n logn) algorithm for this problem. The rectilinear minimum spanning tree for a set of points can thus be computed optimally without using the Voronoi diagram. This algorithm can also be extended to obtain a rectilinear minimum spanning tree for a set of nonintersecting simple polygons.The results in this paper are a part of Y. C. Yee's Ph.D. thesis done at SUNY at Albany. He was supported in part by NSF Grants IRI-8703430 and CCR-8805782. S. S. Ravi was supported in part by NSF Grants DCI-86-03318 and CCR-89-05296.     

Barrier layer effect of tantalum on the electromigration in sputtered copper films on hydrogen silsesguioxane and SiO2

As IC devices scale down to the submicron level, the resistance-capacitance (RC) time delays are the limitation to circuit speed. A solution is to use low dielectric constant materials and low resistivity materials. In this work, the influence of underlying barrier Ta on the electromigration (EM) of Cu on hydrogen silsesquioxane (HSQ) and SiO₂ substrates was investigated. The presence of a Ta barrier not only improves the adhesion between Cu and dielectrics, but also enhances the crystallinity of Cu film and improves the Cu electromigration resistance. The activation energy obtained suggests a grain boundary migration mechanism and the current exponent calculated indicates the Joule heating effect.     

不含4圈的最大简单图边数的下界

证明了具有不小于6个顶点的不包含4圈的简单图的最大可能边数的下界是2n-5。     

一种智能卡口令认证方案的分析与改进

袁,吕提出了一种智能卡口令认证方案.在他们的方案中,用户能随意更改口令,远程系统不需要存储用户的口令表或验证表,并能防止重放攻击.作者指出袁-吕方案不能抵抗假冒攻击,并进行了改进.     

DKNNS:面向延迟敏感型应用的可扩展精确分布式K近邻搜索算法研究

为了降低用户访问延迟,延迟敏感型网络应用需要选择合适的邻近服务节点响应用户访问请求.分布式K近邻搜索通过可扩展的选择距任意用户节点邻近的K个服务节点,可以有效满足网络应用延迟优化的目的.已有工作在精确度以及可扩展性等方面存在不足.针对可扩展精确的K近邻搜索问题,文中提出了分布式K近邻搜索方法DKNNS(distributed K nearest neighbor search).DKNNS将大量的服务节点组织为邻近性感知的多级环,通过最远节点搜索机制选择优化的K近邻搜索初始化节点,然后基于回退方式快速的在目标节点邻近区域发现K个近邻.基于理论分析,模拟测试以及真实环境下的部署实验发现,在不同规模的节点集合下,DKNNS算法能够确定近似最优的K个服务节点.且DKNNS的查询延迟,查询开销均显著低于Meridian算法.最后,DKNNS的返回结果相对于Meridian具有较高的稳定性.