Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet

BACKGROUND: Reduced oxygen availability at high altitude is associated with increased neonatal and infant mortality. We hypothesized that native Tibetan infants, whose ancestors have inhabited the Himalayan Plateau for approximately 25,000 years, are better able to maintain adequate oxygenation at high altitude than Han infants, whose ancestors moved to Tibet from lowland areas of China after the Chinese military entered Tibet in 1951. METHODS: We compared arterial oxygen saturation, signs of hypoxemia, and other indexes of neonatal wellbeing at birth and during the first four months of life in 15 Tibetan infants and 15 Han infants at 3658 m above sea level in Lhasa, Tibet. The Han mothers had migrated from lowland China about two years previously. A pulse oximeter was placed on each infant's foot to provide measurements of arterial oxygen saturation distal to the ductus arteriosus. RESULTS: The two groups had similar gestational ages (about 38.9 weeks) and Apgar scores. The Han infants had lower birth weights (2773 +/- 92 g) than the Tibetan infants (3067 +/- 107 g), higher concentrations of cord-blood hemoglobin (18.6 +/- 0.8 g per deciliter, vs. 16.7 +/- 0.4 in the Tibetans), and higher hematocrit values (58.5 +/- 2.4 percent, vs. 51.4 +/- 1.2 percent in the Tibetans). In both groups, arterial oxygen saturation was highest in the first two days after birth and was lower when the infants were asleep than when they were awake. Oxygen saturation values were lower in the Han than in the Tibetan infants at all times and under all conditions during all activities. The values declined in the Han infants from 92 +/- 3 percent while they were awake and 90 +/- 5 percent during quiet sleep at birth to 85 +/- 4 percent while awake and 76 +/- 5 percent during quiet sleep at four months of age. In the Tibetan infants, oxygen saturation values averaged 94 +/- 2 percent while they were awake and 94 +/- 3 percent during quiet sleep at birth and 88 +/- 2 percent while awake and 86 +/- 5 percent during quiet sleep at four months. Han infants had clinical signs of hypoxemia--such as cyanosis during sleep and while feeding--more frequently than Tibetans. CONCLUSIONS: In Lhasa, Tibet, we found that Tibetan newborns had higher arterial oxygen saturation at birth and during the first four months of life than Han newborns. Genetic adaptations may permit adequate oxygenation and confer resistance to the syndrome of pulmonary hypertension and right-heart failure (subacute infantile mountain sickness).     

布正伟新作八人谈——思想与创作共舞：读《创作视界论》谈布正伟先生

作为在高等院校设计院工作的一名建筑师．除埋头设计外，我对理论问题有相当的偏好．这种偏好又带有很强的实用主义色彩。尤其对那些既有精妙设计．又有睿智思想的建筑师很是崇拜．这当然包括设计作品和理论专著文章。而且每每喜欢将作品与理论文章对照着来读，字里行间仿佛看到一个个作品跃然纸上．而实际工程又仿佛在叙述着作者的思想．这种读法令我了解了许多建筑师。然而不难发现．     

用最小二乘法恢复逐行倒相副载波

介绍ＰＡＬ制彩色全电视信号中色同步信号编码原理及恢复逐行倒相副载波的过程中，两种计算色同步信号相位角的方法。并且在实验的基础上得出：最小二乘法在ＰＡＬ制电视信号的副载波相位角计算中不仅可以满足精度要求，而且简便灵活。     

Optic flow field segmentation and motion estimation using a robustgenetic partitioning algorithm

Optic flow motion analysis represents an important family of visual information processing techniques in computer vision. Segmenting an optic flow field into coherent motion groups and estimating each underlying motion is a very challenging task when the optic flow field is projected from a scene of several independently moving objects. The problem is further complicated if the optic flow data are noisy and partially incorrect. In this paper, the authors present a novel framework for determining such optic flow fields by combining the conventional robust estimation with a modified genetic algorithm. The baseline model used in the development is a linear optic flow motion algorithm due to its computational simplicity. The statistical properties of the generalized linear regression (GLR) model are thoroughly explored and the sensitivity of the motion estimates toward data noise is quantitatively established. Conventional robust estimators are then incorporated into the linear regression model to suppress a small percentage of gross data errors or outliers. However, segmenting an optic flow field consisting of a large portion of incorrect data or multiple motion groups requires a very high robustness that is unattainable by the conventional robust estimators. To solve this problem, the authors propose a genetic partitioning algorithm that elegantly combines the robust estimation with the genetic algorithm by a bridging genetic operator called self-adaptation     

Loss of heterozygosity of the von Hippel Lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas

Carcinoma in ulcerative colitis (UC) develops from dysplastic precursor lesions, which include flat dysplasia (FD) and polypoid dysplasias (PD). PD may present as single or multiple polypoid structures or as plaque-like lesions that, independent of histological grade, are an indication for colectomy. PDs are histologically similar to adenomas and may not be readily distinguished by light microscopy. It is not known whether FD and PD are different entities, or whether they represent etiologically similar lesions with different morphological expression. We microdissected 25 cases of UC with PD and 19 samples of FD with surrounding chronic colitis (CC) in UC. Loss of heterozygosity (LOH) at the von Hippel Lindau (vHL) gene locus and the putative tumor suppressor genes APC, INK4A (9p16), and p53 was studied. LOH of the vHL gene, INK4A (9p16), and APC was also studied in 11 sporadic adenomas of the colon. LOH at the vHL locus was present in 50% of the samples of PD and in 12% of the samples of FD. LOH was seen in CC close to PD and FD in 26% and 12% of cases, respectively. No adenoma showed LOH of the vHL gene markers studied. LOH in p53 was seen in PD in 16% cases and in FD in 42% cases and in CC close to PD and FD in 0% and 14% cases, respectively. LOH patterns between PD and FD of the markers for APC and 9p16 were not different. LOH in APC was seen in two of five cases of adenoma. We conclude that PD and FD share genetic alterations in APC and 9p16 genes. More frequent involvement of the VHL gene in PD and surrounding CC and involvement of p53 in HGD and CC in FD may represent genetic differences between the development of PD and FD and may be the cause of the different morphology. The infrequency of LOH at the vHL locus in adenomas versus PD may serve as a discriminator between adenomas and PD in diagnostically problematic cases.     

半导体光开关工作电流和速率的理论分析

本文从载流子连续性方程出发，采用半导体双异质结概念，从理论上推出了计算半导体光波导开关工作电流和速率的理论公式，为器件选取工作电流和提高开关速率提供了理论依据．     

精品课程教学录像的建设现状分析与建议

教学录像是精品课程建设的重要内容之一。为了开发集教学性、科学性、技术性与艺术性于一体的精品课程教学录像,针对精品课程教学录像的性质,参照其上网技术指标及网上浏览的特点,对其建设现状进行分析,并提出了精品课程教学录像建设的建议。     

基于SAP接口技术的移动终端解决方案

越来越多的企业正在或者即将用SAP作为ERP的应用载体。企业在得益于ERP精细化管理的同时,往往也为ERP与其他子系统整合集成所烦恼。介绍了几种应用于SAP的接口技术,其中包括RFC、ALE-IDOC、BAPI、SAP-DCOM以及Web Service接口技术。并且在此基础上,列举了企业内部的一个实例,展现了SAP通过接口技术与外部的PDA移动终端系统整合,从而解决了维修服务行业从接收工单、记录维修、备件管理等在移动环境下的应用需求。     

车联网中基于轨迹预测的无人机动态协同优化覆盖算法

针对城市车联网中出现的基站覆盖空洞及局部流量过载等问题,提出了一种基于车辆轨迹预测信息的动态预部署方案。首先,为了训练得到统一的seq2seq-GRU轨迹预测模型,多个携带边缘计算服务器的无人机在分布式联邦学习与区块链的架构下,去除中心聚合节点,采取改进的Raft算法,在每轮训练中根据贡献数据量的大小,选举得到节点来完成参数聚合及模型更新任务。其次,基于模型预测结果,提出了一种改进的虚拟力向导部署算法,通过各虚拟力来引导无人机进行动态地部署以提升车辆的接入率及通信质量。仿真结果表明,提出的训练架构能够加速模型的训练,部署算法在提升车辆接入率的同时提升了车辆与无人机之间的通信质量。     

含碘水源先氯后氨消毒中副产物生成特性研究

以含碘水为研究对象,探究了先氯后氨工艺的THM4与I-THMs生成特性,并探究了该工艺的关键影响因子——氯接触时间、溴碘比、pH,同时以CTI与GTI为指标对其进行毒性评价,为水厂工艺调节提供理论依据.其中,先氯后氨工艺的总T H Ms生成量介于氯胺消毒与自由氯消毒之间,并且随着氯接触时间的增加,生成的CHCl3增加了26.5％,而I-THMs减少了58.7％;随着溴碘比的增加,溴代率和生成的THM4呈上升趋势而碘代率和I-THMs呈下降趋势;溴碘共存时,该工艺受pH影响复杂,在pH=6时产生的THMs总量最少.从毒性方面进行评价,先氯后氨工艺的毒性介于氯化和氯胺化消毒之间,30 min为比较合适的氯接触时间,此时与pre-NH2 Cl相比,细胞毒性和基因毒性分别减少了79.0％和53.4％;在溴碘比为3:1时产生的毒性最低.