Protein binding study of isoflavone, perillyl alcohol and S-ibuprofen by high-performance frontal analysis

High-performance frontal analysis (HPFA) was used for a protein binding study of isoflavones (daidzein, genistin, and genistein), enantiomers of perillyl alcohol and S-ibuprofen to human serum albumin (HSA). The analyses were performed on a Develosil and Inertsil 100-Diol-5 column (10 cm×4.6mm). Sodium phosphate solution (pH 7.4, ionic strength 0.17) was used as the mobile phase at a flow rate of 1 ml/min. To ensure the drug to be eluted as a trapezoidal peak with a plateau, injection volumes were each fixed up the zonal profile with an evident plateau appears. The unbound drug concentration was determined from a plateau height of the plateau region after that experimental data were fitted by Scatchard equation. The binding constants (K) and total binding affinities (nK) of drugs to HSA were calculated, respectively.     

应用PIMS选油模型实施进口原油优化选购

应用AspenTech公司PIMS软件，模拟炼油企业生产经营过程，综合考虑原油成本、产品价格以及长岭分公司炼油厂加工流程特点和产品质量等要求，建立了适用于该厂的原油选购模型。利用该模型对该企业2002年第三季度进口原油品种进行优化选择，对综合效益好的原油实施采购。实际生产数据表明，该模型比较准确。     

真空联合堆载预压法加固软基实践研究

简要介绍了凫洲大桥南引道软基真空联合堆载预压处理方案,并对软基处理效果进行了分析,得出了真空联合堆载预压法施工工艺成熟,施工方法简单,能增加地基承载力的结论,可供类似工程参考。     

大坝洪水漫顶风险评估

洪水漫顶是导致大坝溃坝的主要原因之一,大坝洪水漫顶风险评估是大坝风险评估的重要组成部分。为此,简要介绍了大坝洪水漫顶的风险模型,并通过实例详细地讨论了模型中各有关参数的不确定性处理方法,探讨了入库洪水的不确定性对洪水漫顶风险率的影响以及按规范设计的大坝的防洪能力问题。     

MIP-CGP工艺专用催化剂CGP-1的开发与应用

阐述了生产汽油组分满足欧Ⅲ排放标准并多产丙烯的催化裂化工艺（简称MIP-CGP）专用催化剂（简称CGP-1）的研究开发与工业应用结果。CGP-1催化剂的基质具有良好的容炭性能，使活性组元受到良好保护，其优势作用在第二反应区得以充分发挥，具有更高的氢转移活性和强的汽油小分子烯烃裂化活性。中国石化九江分公司和镇海炼化公司的MIP-CGP工业试验标定结果表明，与常规FCC相比，采用CGP-1催化剂的MIP-CGP技术在生产烯烃体积分数小于18％的汽油组分的同时，丙烯产率达到8％以上。此外，汽油诱导期大幅提高，抗爆指数增加；总液体收率有所提高，干气产率下降，焦炭选择性良好。