Performance investigation on a novel 3D wave flow channel design for PEMFC

Flow field structure can largely determine the output performance of Polymer electrolyte membrane fuel cell. Excellent channel configuration accelerates electrochemical reactions in the catalytic layer, effectively avoiding flooding on the cathode side. In present study, a three-dimensional, multi-phase model of PEMFC with a 3D wave flow channel is established. CFD method is applied to optimize the geometry constructions of three-dimensional wave flow channels. The results reveal that 3D wave flow channel is overall better than straight channel in promoting reactant gases transport, removing liquid water accumulated in microporous layer and avoiding thermal stress concentration in the membrane. Moreover, results show the optimal flow channel minimum depth and wave length of the 3D wave flow channel are 0.45 mm and 2 mm, respectively. Due to the periodic geometric characteristics of the wave channel, the convective mass transfer is introduced, improving gas flow rate in through-plane direction. Furthermore, when the cell output voltage is 0.4 V, the current density in the novel channel is 23.8% higher than that of conventional channel.     

0?1膨胀负二项回归模型在COVID?19疫情分析中的应用

在公共卫生等应用领域，经常会同时出现零观测值、一观测值较多的情况. 为更好地拟合这类数据，采用0?1膨胀负二项分布及其回归模型进行分析. 在数据扩充基础上，结合Pólya?Gamma潜变量对模型参数进行贝叶斯推断. 最后，对我国湖北省2019冠状病毒病(COVID?19)死亡数据集进行分析. 研究表明，0?1膨胀负二项回归模型能够达到更好的拟合效果.     

紫色马铃薯酒发酵工艺优化及主发酵期花青素与色泽的动态变化

以紫色马铃薯为原料，在单因素的基础上，通过响应面法对紫色马铃薯酒的发酵工艺参数进行优化。最佳发酵工艺参数为:马铃薯与面粉比1:0.6、料水比1:1 (g/mL)、α-淀粉酶添加量8.5 U/g、酒曲添加量0.45%。此工艺在28 ℃下发酵14 d，得到的紫色马铃薯酒酒精度13.5%vol，花青素含量166.34 mg/mL，酒体澄清透明呈紫红色，酸甜适中，有独特酒香，综合感官评定得分90分。测定主发酵期花青素和色泽的动态变化，分析表明，紫色马铃薯酒在发酵过程中花青素呈现先上升后下降的趋势，色度呈现先下降后趋于平缓的趋势，色调则与之相反。聚合色度和褐变指数总体均呈现逐渐上升的趋势。试验结果为工业化生产紫色马铃薯酒提供理论依据。     

基于Freescale的水质氨氮检测系统的设计

针对水质污染情况的严重性和水质主要污染源之一的氨氮缺乏实时检测的情况，设计了一套基于Freescale单片机芯片的水质氨氮检测系统，可以实时和快速地计算出水质中氨氮的含量。检测系统的硬件部分设计主要包括微处理器模块、温度控制模块、存储模块、信号采集模块以及通信模块的电路设计，软件部分对不同的模块进行程序设计以及上位机软件平台的开发。最后对整个系统进行实验测试，实验结果表明检测系统可以满足氨氮检测的精度要求。     

Improved Input and State Estimation for Linear Stochastic Systems with Direct Feedthrough

This paper is concerned with the problem of joint input and state estimation for linear stochastic systems with direct feedthrough. Based on the fact that each unknown input between any two time steps is always bounded, a novel improved algorithm is proposed. Compared with existing results, this algorithm can effectively enhance estimation accuracy. Moreover, the stability of the algorithm is also discussed. Finally, an illustrative example is given to demonstrate the effectiveness of the proposed approach.     

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation.     

开关磁阻直线电机的设计及其推力优化

设计了一种开关磁阻直线电机,使用JMAG软件对其进行了仿真和优化。进行了推力公式的推导,研究了导通顺序和初始位置对电机推力的影响,并分析了三种典型情况的磁力线分布。对电机的定子和动子的齿部和轭部高度、宽度及铁耗进行仿真优化,得出了最优参数。将有取向硅钢应用于该电机,研究了推力与轧制角的关系,并与使用普通硅钢的开关磁阻直线电机进行了对比,推力有一定提升。提出在动子齿部开切向槽的方案,结果表明,开切向槽对推力的影响较小,并能显著减小推力波动。