全文获取类型
收费全文 | 1023篇 |
免费 | 26篇 |
国内免费 | 9篇 |
专业分类
电工技术 | 11篇 |
综合类 | 1篇 |
化学工业 | 153篇 |
金属工艺 | 12篇 |
机械仪表 | 15篇 |
建筑科学 | 96篇 |
矿业工程 | 29篇 |
能源动力 | 44篇 |
轻工业 | 48篇 |
水利工程 | 6篇 |
石油天然气 | 8篇 |
无线电 | 128篇 |
一般工业技术 | 124篇 |
冶金工业 | 96篇 |
原子能技术 | 7篇 |
自动化技术 | 280篇 |
出版年
2022年 | 4篇 |
2021年 | 11篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 15篇 |
2017年 | 16篇 |
2016年 | 14篇 |
2015年 | 15篇 |
2014年 | 18篇 |
2013年 | 95篇 |
2012年 | 42篇 |
2011年 | 39篇 |
2010年 | 28篇 |
2009年 | 41篇 |
2008年 | 44篇 |
2007年 | 55篇 |
2006年 | 62篇 |
2005年 | 62篇 |
2004年 | 55篇 |
2003年 | 56篇 |
2002年 | 34篇 |
2001年 | 31篇 |
2000年 | 33篇 |
1999年 | 32篇 |
1998年 | 23篇 |
1997年 | 22篇 |
1996年 | 24篇 |
1995年 | 19篇 |
1994年 | 15篇 |
1993年 | 8篇 |
1992年 | 6篇 |
1991年 | 12篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 14篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 10篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1975年 | 4篇 |
1973年 | 2篇 |
1968年 | 3篇 |
1963年 | 3篇 |
排序方式: 共有1058条查询结果,搜索用时 15 毫秒
21.
Peter K. Windsor Stephen P. Plassmeyer Dominic S. Mattock Jonathan C. Bradfield Erika Y. Choi Bill R. Miller III Byung Hee Han 《International journal of molecular sciences》2021,22(6)
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation of Aβ fibrils. In the present study, we further sought to investigate the structural basis of the Aβ disaggregating activity of biflavonoids and their interactions at the atomic level. A thioflavin T (ThT) fluorescence assay revealed that amentoflavone-type biflavonoids promote disaggregation of Aβ fibrils with varying potency due to specific structural differences. The computational analysis herein provides the first atomistic details for the mechanism of Aβ disaggregation by biflavonoids. Molecular docking analysis showed that biflavonoids preferentially bind to the aromatic-rich, partially ordered N-termini of Aβ fibril via the π–π interactions. Moreover, docking scores correlate well with the ThT EC50 values. Molecular dynamic simulations revealed that biflavonoids decrease the content of β-sheet in Aβ fibril in a structure-dependent manner. Hydrogen bond analysis further supported that the substitution of hydroxyl groups capable of hydrogen bond formation at two positions on the biflavonoid scaffold leads to significantly disaggregation of Aβ fibrils. Taken together, our data indicate that biflavonoids promote disaggregation of Aβ fibrils due to their ability to disrupt the fibril structure, suggesting biflavonoids as a lead class of compounds to develop a therapeutic agent for Alzheimer’s disease. 相似文献
22.
Mootaz M. Salman Zaid Al-Obaidi Philip Kitchen Andrea Loreto Roslyn M. Bill Richard Wade-Martins 《International journal of molecular sciences》2021,22(9)
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools. 相似文献
23.
Christer Löfstedt Bill S. Hansson Erik Petersson Peter Valeur Andrew Richards 《Journal of chemical ecology》1994,20(1):153-170
Extracts of different body parts of adult Trichoptera were tested for electrophysiological activity. Extracts of the IVth and Vth abdominal sternites of femaleHydropsyche angustipennis, Rhyacophila nubila, andR. fasciata, containing a paired exocrine gland, elicited significant electroan-tennographic responses when tested on conspecific male antennae. The paired gland occurs also in males of all the species, and inH. angustipennis, extracts from males were more active than female extracts when tested on male antennae. Female and male extracts from all species were analyzed by gas chromatography with simultaneous flame ionization and electroantennographic detection (EAD). EAD-active peaks in female extracts, stimulating male antennae, were identified inH. angustipennis as nonan-2-one; and inR. nubila andR. fasciata as heptan-2-one, heptan-2-ol, nonan-2-one, and nonan-2-ol. EAD-active components from maleH. angustipennis stimulating male antennae were octan-2-one, nonan-2-one (major peak), (Z)-6-nonen-2-one, decan-2-one, and a methylbranched decan-2-one. Female extracts and synthetic mixtures of compounds identified from femaleH. angustipennis andR. fasciata were tested for attractivity in the field. High catches with control traps obscured the results, but a synthetic mixture of the four identified compounds was significantly attractive and not different from female extracts for attracting maleR. fasciata. InH. angustipennis, a synthetic six-component male blend, in which nonan-2-one was the major component, attracted significant numbers of male and femaleH. angustipennis. Extracts of maleR. nubila andR. fasciata contained acetophenone and hexanoic and octanoic acids but did not have any electrophysiological or behavioral activity on either male or female antennae of conspecifics. The occurrence of a female sex pheromone inRhyacophila and an aggregation pheromone inHydropsyche corresponds to earlier described differences in mating behaviors in the Rhyacophilidae and Hydropsychidae. 相似文献
24.
Colin?WilbornEmail author Jacqueline?Beckham Bill?Campbell Travis?Harvey Melyn?Galbreath Paul?La Bounty Erika?Nassar Jennifer?Wismann Richard?Kreider 《Journal of the International Society of Sports Nutrition》2005,2(2):4-31
Obesity and its associated disorders are a growing epidemic across the world. Many genetic, physiological, and behavioral
factors play a role in the etiology of obesity. Diet and exercise are known to play a valuable role in the treatment and prevention
of obesity and associated disorders such as hypertension, heart disease, and diabetes. Therefore, the purpose of this review
is to examine the prevalence, etiology, consequences, and treatment of obesity. 相似文献
25.
Michail V. Kozlov Junwei Zhu Peter Philipp Wittko Francke Elena L. Zvereva Bill S. Hansson Christer Löfstedt 《Journal of chemical ecology》1996,22(3):431-454
The fifth abdominal segment of femaleEriocrania semipurpurella (Stephens) andE. sangii (Wood) contains a pair of exocrine glands. Hexane extracts of this segment were prepared from both species and analyzed by gas chromatography with simultaneous flame ionization and electroantennographic detection (EAD). For both species, the EAD active peaks were identified as nonan-2-one, (Z)-6-nonen-2-one, and (Z)-6-nonen-2-ol by means of mass spectrometry and comparison of retention indices with those of synthetic standards. Enantiomeric separation of chiral alcohols from the female extracts was achieved by gas chromatographic analysis on a cyclodextrin column. InE. semipurpurella, a mixture of (2S,6Z)-nonen-2-ol and (2R,6Z)-nonen-2-ol (2: I) was found, whereas inE. sangii (2S,6Z)-nonen-2-ol was the predominant enantiomer and only traces of theR enantiomer were indicated by the antennal response. In field tests, a blend of the three compounds was not attractive to conspecific males. A subtractive assay showed that the alcohol in various enantiomeric mixtures was the only attractive compound, whereas addition of (Z)-6-nonen-2-one to the alcohol completely inhibited the attraction of both species. A trapping experiment including a wide range of ratios between theR andS enantiomers showed that baits containing 95–100% of theS enantiomer were attractive to maleE. sangii, whereas males ofE. semipurpurella were attracted to all tested ratios of the enantiomers. However, the response profiles of maleE. semipurpurella differed between populations from southern Sweden, south Finland, and the Kola Peninsula in Russia. In south Sweden males were maximally attracted to a racemic mixture of the alcohols. At the Kola PeninsulaE. semipurpurella was attracted to baits containing 95–100% of theR enantiomer. In south Finland all tested ratios between 0 and 100%R enantiomer trappedE. semipurpurella, but the trap catches appeared to be bimodally distributed with peaks around 15 and 70%R enantiomer. The trapping results suggest the existence of pheromone races or sibling species among the specimens identified asE. semipurpurella.Dedicated to Prof. H. J. Bestmann on the occasion of his 70th birthday. 相似文献
26.
Nataraj Nandita Adam Elisabeth Hansson Bill S. Knaden Markus 《Journal of chemical ecology》2021,47(12):1042-1048
Journal of Chemical Ecology - Many pollinating insects exhibit flower constancy, i.e. they target flower species they have already experienced and fed from. While the insects might profit from... 相似文献
27.
Bit commitment schemes are at the basis of modern cryptography. Since information-theoretic security is impossible both in the classical and in the quantum regime, we examine computationally secure commitment schemes. In this paper we study worst-case complexity assumptions that imply quantum bit commitment schemes. First, we show that QSZK \({\not\subseteq}\) QMA implies a computationally hiding and statistically binding auxiliary-input quantum commitment scheme. We then extend our result to show that the much weaker assumption QIP \({\not\subseteq}\) QMA (which is weaker than PSPACE \({\not\subseteq}\) PP) implies the existence of auxiliary-input commitment schemes with quantum advice. Finally, to strengthen the plausibility of the separation QSZK \({\not\subseteq}\) QMA, we find a quantum oracle relative to which honest-verifier QSZK is not contained in QCMA, the class of languages that can be verified using a classical proof in quantum polynomial time. 相似文献
28.
Bill Moran Du Q. Huynh Xuezhi Wang Michael Edwards Andrew Harris Barbara F. La Scala 《Digital Signal Processing》2009,19(5):793-808
We describe here a method for the analysis of materials on a conveyor belt using the natural gamma spectra collected with a BGO (Bismuth Germanate) gamma ray detector. This detector collects gamma ray emissions from the Potassium (K), Uranium (U), and Thorium (Th) atoms in the materials. Based on these data, and using a Poisson model for the data generation, a statistical model is proposed and an approximate maximum likelihood (ML) technique based on the expectation-maximization (EM) algorithm is then used to estimate the amount of each of the three elements in the material. The statistical model is further refined to incorporate parameters of drift in the detector and an estimation technique for this is developed and tested against real data. The Cramér–Rao lower bounds for the estimators are calculated. 相似文献
29.
Bill Venners 《程序员》2009,(5):81-83
Twitter将部分应用从Ruby迁移到了Scala。三位开发者详谈决策背后的因素、Scala在现实应用中遇到的困难以及Scala对编程风格的影响。 相似文献
30.
Bill 《Windows IT Pro Magazine》2009,(8):41-41
Windows XP模式可用在Windows 7的Professiona Enterprise和Ultimate版本中。它实质上由两部分构成版的Virtual PC,名为Windows Virtual PC:通过Windows Firewall进行配置并能自动更新的Windows XP Professiona SP3虚拟机(VM)。如果OEM选择安装Windows XP模式,可以预先在新计算机上安装它,也可以通过微软站点下载它。 相似文献