Present Status of the Nd:YAG Thomson Scattering System Development for Time Evolution Measurement of Plasma Profile on Heliotron J

A new high repetition rate Nd:YAG Thomson scattering system is developed for the Heliotron J helical device.A main purpose of installing the new system is the temporal evolution measurement of a plasma profile for improved confinement physics such as the edge transport barrier (H-mode) or the internal transport barrier of the helical plasma.The system has 25 spatial points with ～10mm resolution.Two high repetition Nd:YAG lasers (>550mJ@ 50Hz) realize the measurement of the time evolution of the plasma profile with ～10ms time intervals.Scattered light is collected by a large concave mirror (D=800 mm,f/2.25) with a solid angle of ～100 mstr and transferred to interference filter polychromators by optical fiber bundles in a staircase form.The signal is amplified by newly designed fast preamplifiers with DC and AC output,which reduces the low frequency background noise.The signals are digitized with a multi-event QDC,fast gated integrators.The data acquisition is performed by a VME-based system operated by the CINOS.     

Thermophysical properties of (U,Y)O2

We prepared polycrystalline pellets of (U,Y)O₂, containing YO_1.5 up to 11 mol.%. We performed indentation tests on the pellets, and evaluated the Young’s modulus and hardness. We measured the heat capacity and the thermal diffusivity, and evaluated the thermal conductivity. We succeeded in evaluating the effect of Y content on the thermophysical properties of (U,Y)O₂. We revealed that the Young’s modulus, hardness, and thermal conductivity of (U,Y)O₂ decreased with increasing the Y content.     

Discovery of a Novel Scaffold as an Indoleamine 2,3‐Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid,Longamide B

Indoleamine 2,3‐dioxygenase 1 (IDO1) has emerged as a key target for cancer therapy, as IDO1 plays a critical role in the capacity of tumor cells to evade the immune system. The pyrrolopiperazinone alkaloid longamide B and its derivatives were identified as novel IDO1 inhibitors based on docking studies and small library synthesis. The thioamide derivative showed higher IDO1 inhibitory activity than longamide B, and displayed an activity similar to that of a representative IDO1 inhibitor, 1‐methyl‐tryptophan. These results suggest that the pyrrolopiperazinone scaffold of longamide B could be used in the development of IDO1 inhibitors.     

Estimating the germicidal effect of upper-room UVGI system on exhaled air of patients based on ventilation efficiency

Upper room (UR)-ultraviolet germicidal (UVGI) systems, one of several disinfection applications of UV, target airborne infectious diseases in rooms of buildings such as healthcare facilities. Previous studies have introduced many experiments showing the germicidal effect of UR-UVGI systems. In this study, a novel numerical method of estimating the germicidal effect of UR-UVGI systems for air exhaled by ward patients was introduced. The method adopts and modifies the concept of ventilation efficiency because the germicidal effect depends upon how the air containing airborne infectious particles flows and stays within UV-radiated area. A case study based on a four-patient ward showed that UV doses were correlated with the age of the air exhaled by a source patient, as expected. Moreover, the UV doses were considerably affected by the position of the UR-UVGI system. Inactivation rates of the influenza virus estimated using the UV doses, were in the range of 48–74%, and those of Mycobacterium tuberculosis were 68–90% in the breathing area of a neighboring patient. The results indicate not directly the decreased concentration of airborne infectious particles, but the possibility of inactivation caused by the UR-UVGI system, which is useful for system optimization.     

Ventilation efficiency of void space surrounded by buildings with wind blowing over built-up urban area

This paper outlines methods for evaluating wind-induced ventilation efficiency in void spaces in built-up urban areas. The indices of ventilation efficiency express quantitatively the ability to deliver fresh upper-tier wind to the lower tiers of void spaces and dilute pollutants emitted therein. The evaluation of ventilation efficiency is based on detailed flow analysis. The scales for ventilation efficiency, (SVEs l, 2, 3, and 6) were originally derived by the authors for room air ventilation and are also useful when applied to the exchange of air in void spaces in built-up urban areas. The other scales, namely local purging flow rate (L-PRF), visitation frequency (VF), and residence time (RT), were also re-defined by the authors for room air ventilation and had been applied for urban street canyons. They are based on detailed flow analysis and can be evaluated more easily with computational fluid dynamics (CFD) than flow modeling experiments. CFD simulation example is used to illustrate the concept of the proposed method and it is not meant to indicate the level of CFD set up for urban flow calculations. The effectiveness of the proposed method will be demonstrated more in future study.     

Denatured-jacalin derivatives with selective recognition for O-linked glycosides (ST,T, Tn,and STn Type) on IgA1 hinge region

Immunoglobulin A1 (IgA1) concentration in the plasma of patients with IgA nephropathy (IgAN) as the cause of renal failure is higher than that in the plasma of normal controls. IgA1 with abnormal sugars is considered to deposit in the glomerular mesangium, aggravating nephritis in IgAN. Jacalin is a lectin that recognizes sugars on IgA1. However, its selective-recognition for normal-type (ST type, NeuAc-α(2,3)-Gal-β(1,3)-GalNAc) and abnormal-type (T type, Gal-β(1,3)-GalNAc; Tn type, GalNAc; STn type, NeuAc-α(2,6)-GalNAc) sugars α-O-linked to serine/threonine in IgA1 is weak. Therefore, jacalin cannot be used for recognizing specific sugar types on IgA1. We attempted to develop a new recognition method for specific sugar types on IgA1 by utilizing the multirecognition capability of jacalin. Its binding abilities were regulated by heat denaturation with suitable template sugar (galactose or N-acetylgalactosamine). Further, we successfully prepared denatured-jacalin derivatives, which recognized ST-/T-type sugars on IgA1, by sugar-immobilized affinity chromatography. Enzyme-linked immunosorbent assay of denatured-jacalin derivatives, showed the ratios of abnormal sugars on IgA1 in the plasma of IgAN patients and normal controls to be approximately 60% and 20%, respectively. The results proved that profiling of sugar types in IgAN can successfully be performed by solely using jacalin derivatives.     

Antifungal activity of the fermentation product of herbs by lactic acid bacteria against tinea

The fermentation product of herbs by lactic acid bacteria (FHL), in which Enterococcus faecalis TH10 predominated, was assayed for antifungal activity against tinea. The antifungal activity of FHL was as high as that of a synthetic fungicide. Autoclaving FHL did not reduce its antifungal activity, whereas neutralizing it did. The results suggested that nonproteinaceous compounds or organic acids in FHL could inhibit the growth of the dermatophyte tinea under low-pH conditions, and that malonic acid and acetic acid could have especially high antifungal activity against tinea.     

New Paradigms in Wireless Communication Systems

This paper discusses what a new paradigm can be in wireless communication systems of the twenty-first century. First, it suggests two directions for the new paradigm; one is “micro- and nano-device communication system” which is the projected scenario considering that the entities in source and destination have been shrinking throughout the history of wireless communication systems. The second direction is “networked robot system”, which emerges as a natural extension of mobile ad hoc networking where the networking is closely related to motion control of robots. Secondly, it shows two interesting research topics, “the new communication protocol design” and “signal processing”, respectively, that arise in the wake of the fusion between the two directions in the novel communication paradigm. Finally, it considers a new science of wireless communications in the twenty-first century. Shinsuke Hara received the B.Eng., M.Eng. and Ph.D. degrees in communications engineering from Osaka University, Osaka, Japan, in 1985, 1987 and 1990, respectively. From April 1990 to March 1997, he was an assistant professor in the Department of Communication Engineering, School of Engineering, Osaka University, and from October 1997 to September 2005, he was an associate professor in the Department of Electronic, Information and Energy Engineering, Graduate School of Engineering, Osaka University. Since October 2005, he has been a professor in the Department of Physical Electronics and Informatics, Graduate School of Engineering, Osaka City University. In addition, from April 1995 to March 1996, he was a visiting scientist at Telecommunications and Traffic Control Systems Group, Delft University of Technology, Delft, The Netherlands. His research interests include wireless communications systems and digital signal processing. Hiroyuki Yomo received B.S. degree in communication engineering from Department of Communication Engineering, Osaka University, Osaka, Japan, in 1997, and M.S. and Ph.D. degrees in communication engineering from Department of Electronic, Information, and Energy Engineering, Graduate School of Engineering, Osaka University, Osaka Japan, in 1999 and 2002, respectively. From April 2002 to March 2004, he was a Post-doctoral Fellow in Department of Communication Technology, Aalborg University, Denmark. From April 2004 to September 2004, he was at Internet System Laboratory, NEC Corporation, Japan. Since October 2004, he has been an Assistant Research Professor in Center for TeleInfrastructure (CTIF), Aalborg University, Denmark. His main research interests are access technologies, radio resource management, and link-layer techniques in the area of short-range communication, cellular network, cognitive radio, and sensor network. Petar Popovski received the Dipl.-Ing. in electrical engineering and M.Sc. in communication engineering from the Faculty of Electrical Engineering, Sts. Cyril and Methodius University, Skopje, Republic of Macedonia, in 1997 and 2000, respectively. He received a Ph.D. degree from Aalborg University, Denmark, in 2004. From 1998 to 2001 he was a teaching and research assistant at the Institute of Telecommunications, Faculty of Electrical Engineering in Skopje. He is currently Assistant Professor at the Department of Communication Technology at the Aalborg University. His research interests are related to the PHY-MAC aspects of wireless protocols, wireless sensor networks, random access protocols, and network coding. Kazunori Hayashi received the B.E., M.E. and Ph.D. degrees in communication engineering from Osaka University, Osaka, Japan, in 1997, 1999 and 2002, respectively. He spent 3 months in 2000 at Aalborg University, Denmark, as a Visiting Scholar. Since 2002, he has been with the Department of Systems Science, Graduate School of Informatics, Kyoto University. He is currently an Assistant Professor there. His research interests include digital signal processing for communications systems.     

Development of new dosimetry using extended DNA fibers

We applied fluorescent microscopy to monitor the damage of DNA upon exposure to gamma radiation. Our developed dosimetry demonstrated that the number of breaks in DNA is proportional to the dose of the irradiation but is not dependent on dose rate of the irradiation and the GC content of DNA.     

Development of coincidence transmission electron microscope. III. Incorporation with gamma-type imaging energy filter

We have developed a new analytical transmission electron microscope (TEM), called coincidence TEM, which, in principle, enables observation of elemental mapping images at a high signal-to-noise ratio. We have previously reported the successful observation of an elemental mapping image of a specimen, but over a very long period of time (168 h). To solve this inefficiency, we installed a gamma-type imaging energy filter in the coincidence TEM to remove the no-loss electrons, which are mainly transmitted electrons. This has enabled the intensity of the background signals in the coincidence measurement to be markedly reduced. The coincidence TEM with a gamma-type imaging energy filter allows the coincidence image to be observed in 3 h, thus, the measurement time is shortened by two orders of magnitude. Moreover, the use of a silicon drift detector (SDD) will shorten the measurement time.