Moving from the Consortium to the Reference Desk: Keeping Chat and Improving Reference at the MSU Libraries

The experience of the Mississippi State University (MSU) Libraries illustrates the challenges presented by moving from consortial to local chat, as well as an evaluation of the advantages of chat reference in an academic setting. Countering the consortial, instant-messaging model prevalent in virtual reference today, the MSU Libraries have found chat offers advantages in an academic community. Moving to a local setting, it was possible for the MSU Libraries to maintain quality control over chat transactions while building relationships with faculty and students across campus.     

Fostering Library as a Place for Distance Students: Best Practices From Two Universities

The concept of library as a place is now in action in many academic libraries: from physical library spaces to Web presences. In the constantly growing market of online and distance learning, however, libraries must foster library as a place for students who may never set foot in the physical building. This article provides a profile of two universities serving two very different bodies of distance students as well as the challenges associated with these populations. These libraries work to provide services to distance students that cultivate the library as a place to go for learning, research, and support by focusing on six categories: access, environment, resources, instruction, availability at the point of need, and “being real.” Tangible examples and best practices are provided throughout. This article is based on a presentation given at the 15th National Conference of the Association of College and Research Libraries in Philadelphia in March 2011.     

Structure based virtual screening-driven identification of monastrol as a potent urease inhibitor

Virtual screening uses computer based methods to discover new ligands on the basis of biological structures. Among all virtual screening methods structure based docking has received considerable attention. In an attempt to identify new ligands as urease inhibitors, structure-based virtual screening (SBVS) of an in-house database of 10,000 organic compounds was carried out. The X-ray crystallographic structure of Bacillus pasteurii (BP) in complex with acetohydroxamic acid (PDB Code 4UBP) was used as a protein structure. As a starting point, ~10,000 compounds of our in-house database were analyzed to check redundancy and the compounds found repeated were removed from the database. Finally 6993 compounds were docked into the active site of BP urease using GOLD and MOE-Dock software. A remarkable feature of this study was the identification of monastrol, a well-known KSP inhibitor already in clinical trials, as a novel urease inhibitor. The hits identified were further evaluated by molecular docking and on examination of the affinity predictions, twenty-seven analogs of monastrol were synthesized by a multicomponent Biginelli reaction followed by their in vitro screening as urease inhibitors. Finally twelve compounds were identified as new urease inhibitors. The excellent in vitro activity suggested that these compounds may serve as viable lead compounds for the treatment of urease related problems.     

变化环境下治涝效益估算方法研究

治涝工程建设前后涝区内状况往往会发生变化,承灾体的种类、数量和空间分布也会有所改变,因此,变化环境下治涝工程效益应为有治涝工程情况下比假设无该治涝工程情况下减少的涝灾损失;且各频率的暴雨导致的涝灾损失应为与承泄区各种水位组合下的涝灾损失的数学期望值。本文基于Copula函数和GIS构建的变化环境下治涝效益分析计算模型,用Copula函数构建涝区暴雨和承泄区水位的联合分布,借助GIS技术构建涝区数字高程模型。根据涝区暴雨和承泄区水位遭遇组合下的积水过程估算其涝灾损失,进而计算有治涝工程和假设无该治涝工程两种工况时所有组合下的涝灾损失期望值,从而得到治涝工程效益。以广州市南沙区的一个涝区为例简要说明了治涝效益的分析过程,结果表明,本文构建的治涝效益分析模型能分析涝区内状况和承灾体均发生改变、同时考虑涝区暴雨和承泄区水位全体组合下的治涝效益,可为治涝工程建设的合理决策提供科学依据。     

农民灌溉水费承受能力测算初步研究

应用2006年5个省份110份农户调查问卷,结合农业水价综合改革试点工作,分析了农 民灌溉水费承受能力研究的现状及存在问题,提出传统方法不能全面真实反映农民的承受能力。 通过调查数据分析,农民灌溉水费承受能力的影响因素主要包括经济因素和心理因素,据此提出 了在不同类型地区应测定不同的心理承受能力系数和经济承受能力系数的新承受能力测算模型的 初步设想。     

城镇河道景观规划设计研究——以都江堰博物馆园区河道景观设计为例

河道景观是城镇振兴的重要资源,开发河道景观对于提升城市环境质量、丰富城市景观内容、促进城市社会经济发展具有重要价值。自20世纪60年代环境改造运动兴起以来,城镇河道景观资源的开发受到普遍重视。出于对防洪、灌溉、航运、城市排水等因素的考虑,我国的城镇河道景观资源开发设计工作起步较晚,并且已有的河道景观开发大都千篇一律,流于形式。总结以往河道景观设计的经验教训,结合都江堰博物馆园区河道景观设计实践,提出城镇河道景观设计的思路和方法。     

QUAL2K模型在大凌河流域水资源保护管理中的应用

水质模型的应用,是水质评价及预测的重要手段.本文依据调查与监测的数据,建立了朝阳大凌河流域枯水期阎王鼻子水库至白石水库段的QUAL 2K水质模型,结合GIS系统完成模拟值与监测值的参数估计,并通过水质模型得到验证,为水资源综合管理提供依据.     

Local nonlinear unknown input observer

This paper proposes a new nonlinear unknown input observer. The observer design approach utilizes the first order Taylor expansion. The observer gains are then obtained by a systematic method. In this paper, we added some improvements to this method. The developed approach also can enable observer design for a large class of differentiable nonlinear systems. The necessary and sufficient conditions for the existence of the observer are given. A numerical example is given to illustrate the attractiveness and the simplicity of the new design procedure.     

基于HLA的虚拟战场仿真联邦成员设计与实现

高层体系结构为虚拟战场提供灵活的战场仿真环境。论文简述HLA的组成和原理,分析了基于HLA的虚拟战场仿真系统的组成,详细阐述了雷达、指挥控制和导弹联邦成员的设计,构建雷达发现目标概率、目标威胁排序和导弹命中概率的数学模型,并设计其对象类和交互类,完成战场仿真的联邦成员设计。仿真实验结果表明了所设计仿真系统联邦成员的有效性,使仿真系统中双方打击过程的实时测试仿真达到较好的仿真效果。该仿真系统中的数据模型分析方法,对其它领域内基于HLA的仿真系统设计和开发具有参考价值。     

基于领航位置信息的AUV三维编队控制方法

研究了自治水下机器人（Autonomous Underwater Vehicle,AUV）三维环境中编队控制问题,应用领航一跟随式队形控制方法,仅利用领航者的位置信息及期望编队队形得到虚拟机器人的航行轨迹及速度信息,作为跟随者的航行参考量,应用反步及滑模控制方法为跟随者设计自适应控制律,使其轨迹收敛于虚拟机器人的轨迹,从而与领航者保持期望位姿关系。随后,在具体AUV动力学模型上,利用MATLAB／SIMULINK平台进行了编队控制的仿真研究,实现了预期的控制效果,验证了算法的有效性及实用性。