Augment low-field intra-operative MRI with preoperative MRI using a hybrid non-rigid registration method

Background

Preoperatively acquired diffusion tensor image (DTI) and blood oxygen level dependent (BOLD) have been proved to be effective in providing more anatomical and functional information; however, the brain deformation induced by brain shift and tumor resection severely impairs the correspondence between the image space and the patient space in image-guided neurosurgery.

Method

To address the brain deformation, we developed a hybrid non-rigid registration method to register high-field preoperative MRI with low-field intra-operative MRI in order to recover the deformation induced by brain shift and tumor resection. The registered DTI and BOLD are fused with low-field intra-operative MRI for image-guided neurosurgery.

Results

The proposed hybrid registration method was evaluated by comparing the landmarks predicted by the hybrid registration method with the landmarks identified in the low-field intra-operative MRI for 10 patients. The prediction error of the hybrid method is 1.92 ± 0.54 mm, and the compensation accuracy is 74.3 ± 5.0%. Compared to the landmarks far from the resection region, those near the resection region demonstrated a higher compensation accuracy (P-value = .003) although these landmarks had larger initial displacements.

Conclusions

The proposed hybrid registration method is able to bring preoperatively acquired BOLD and DTI into the operating room and compensate for the deformation to augment low-field intra-operative MRI with rich anatomical and functional information.     

Synthesis of poly[(methyl methacrylate)-co-acrylamide] modified by titanium-triisopropoxide and their thermal stability

Poly[(methyl methacrylate)-co-acrylamide] of various compositions were previously prepared by the radical copolymerization reaction of methyl methacrylate and the acrylamide monomer in a solvent. The copolymers were modified through a resonating salt by the addition reaction of a chlorotitanium-triisopropoxide; the modified resins are called Ti hybrid copolymers. The chemical structure of acrylamide side chain groups in the Ti hybrid copolymers was confirmed by the ash weight after combustion, the characteristic absorption band determined by Fourier transform infrared spectrophotometry (IR) and elementary analysis (EA). The curing temperature and time of the resins were determined from the change in the insoluble resin weight when the extraction was done with a mixture of acetone and methanol using the curing resin samples. The thermal stability of the Ti hybrid copolymers was evaluated using both the thermal-degradation temperature (T_x) measured by thermogravimetric analysis and the thermal degradation at 130 °C for 720 h. The cured resins improved the weight loss of the resins at the T_x, and exhibited a high thermal stability.     

基于Monte Carlo随机模拟的综合交通网络布局评价与决策方法

针对综合交通网络评价指标权重及属性值具有主观性和随机性的特点,提出了基于模拟运算的布局规划方案排序选优的群体随机决策方法.仿真生成满足集结的多个专家对指标重要性偏好排序统计分布的权重,同时考虑交通需求的不确定性对指标值的影响,结合客观熵权计算方案的综合评价值,由多次模拟得到的排序优势度确定方案的优劣差异.根据设计的仿真流程通过算例说明了方法应用的有效性,评价中考虑了主客观因素及随机性特征,可以为网络布局提供科学决策依据.     

基于群体动力学的协同过滤算法及应用

针对传统协同过滤算法稀疏矩阵和推荐精度不高的问题,根据一种社会心理学模型提出了基于群体动力学的协同过滤算法.该算法综合考虑了个体因素和环境因素对用户评分行为的影响,以此来调整传统的评分预测方法,然后为用户进行推荐.实验结果表明,该算法可以明显地提高推荐的精确度,有效地缓解稀疏矩阵问题;同时该算法还可以有效减少积累误差.最后将该算法成功运用在西安景点的推荐服务上.     

面向在线社区用户的群体推荐算法研究

结合现有两种主要群体推荐算法的优势, 建立新的算法框架, 并引入差异度因素对模型进行优化。另外, 考虑到在线社区用户的特点, 定义互动度指标来描述群体成员间的互动程度, 通过分析其与推荐精度之间的关系, 探讨互动度对群体推荐的影响。选取豆瓣网数据进行实验, 并与传统方法进行比较, 结果表明, 融入差异度的算法具有更好的推荐效果, 且有效的互动机制能够保证较高的推荐精度。     

基于海量搜索历史数据的用户兴趣模型

针对互联网搜索引擎环境中,基于海量搜索历史数据分析用户兴趣的问题,提出一种改进的用户兴趣模型。该模型根据用户搜索的历史数据,结合向量空间模型（ VSM ）和TF-IDF算法,递归地回溯出用户兴趣权重列表。为解决用户兴趣变化和时间性能的问题,该模型引入时间遗忘机制进行动态更新,并在Hadoop分布式系统架构下利用MapReduce分布式编程模型进行实现。实验结果表明,改进的用户兴趣模型的查准率和召回率都能达到50',具有较好的可行性和可用性。     

Synthesis and properties of optically active substituted polyacetylenes having carboxyl and/or amino groups

Polyacetylenes having carboxyl and/or amino groups in the side chain were synthesized by the polymerization of N-(2-propynyloxycarbonyl)-l-alanine (1) and l-alanine N-propargylamide (2) catalyzed with a rhodium cation complex. Poly(1_0.5-co-2_0.5) exhibited a larger CD signal than the homopolymers. The polymer mixtures obtained by the polymerization of 1 in the presence of poly(2), and those obtained by the polymerization of 2 in the presence of poly(1) showed specific rotations larger than calculated. The polymerization of propargylamine in the presence of poly(1) did not exhibit significant effect, while the polymer mixtures obtained by the polymerization of propiolic acid in the presence of poly(2) exhibited [α]_D of positive sign, although poly(2) alone exhibited [α]_D of negative sign.     

基于Hough圆卷积变换的孔组检测

为降低孔组测量的成本,提高测量的精确度,提出一种基于Hough国卷积的孔组检测方法.对孔组图像进行中值滤波、拉普拉斯锐化增强和边缘检测;根据孔组半径大小的变化范围,对Hough圆锥进行改进;在此基础上,利用改进的Hough圆锥与边缘检测后的图像进行三维卷积,得到Hough参数空间,计算出孔组的坐标和半径值;采用快速傅立叶变换法代替三维卷积,减少算法的计算时间.实验结果表明,该方法的检测精度高、实时性强,可以用于孔组的自动化检测.     

基于遗忘曲线的微博用户兴趣模型

为解决微博用户兴趣漂移问题,以人类记忆学中遗忘曲线为基础,提出一种微博用户兴趣模型,利用用户历史信息预测当前兴趣。在预测过程中,用户关注某信息的时间距离当前时间越远,该信息越容易被遗忘,其对用户当前兴趣的影响越小;用户关注某一领域的信息越多,印象越深刻,对该领域的兴趣度越高。这两点与人类对知识逐渐遗忘和重复学习的过程具有高度相似性,因此该模型预测准确性更高。实验结果表明,该模型能较好地预测微博用户兴趣,召回率可达85.3％,实用性较强。     

无线传感网动态可认证群组密钥交换协议

无线传感器网络中节点电池电量有限、节点计算能力及存储能力受限,使得现有的大部分群组密钥交换技术不适用于无线传感器网络。针对该问题,提出一种动态的可认证群组密钥交换协议。采用双线性映射技术实现无线传感器网络中节点之间的群组密钥交换。该协议具有可认证性,避免群组密钥交换过程中遭到欺骗攻击及中间人攻击;具有动态性,适用于无线传感器网络节点动态部署;在双线性计算Diffie-Hellman(bilinear computation Diffie-Hellman,BCDH)困难性假设下是可证安全的。分析结果表明,该协议具有较高的安全性和较好的性能。