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71.
为了得到时间更短加载效果相同的加速耐久性试验载荷谱,提出了基于多参数特征保留的载荷谱编辑方法。该方法同时考虑载荷谱的损伤、功率谱密度以及统计参数等信息,对零部件载荷谱的时间进行压缩。以汽车悬架螺旋弹簧的载荷谱为例,采用该方法进行缩减,同时从多个参数特征方面与传统的基于损伤保留的编辑方法所得到的载荷谱进行对比。为了进一步验证编辑效果,采用编辑谱和原始谱对弹簧进行疲劳仿真。结果表明,该方法能够有效缩短汽车零部件的载荷谱,可得到与原始载荷谱具有相同加载效果的编辑载荷谱。 相似文献
72.
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Despite numerous efforts to target epidermal growth factor receptor (EGFR), commonly dysregulated in GBM, approaches directed against EGFR have not achieved the same degree of success as seen in other tumor types, particularly as compared to non-small cell lung cancer (NSCLC). EGFR alterations in glioblastoma lie primarily in the extracellular domain, unlike the kinase domain alterations seen in NSCLC. Small molecule inhibitors are difficult to develop for the extracellular domain. Monoclonal antibodies can be developed to target the extracellular domain but must contend with the blood brain barrier (BBB). We review the role of EGFR in GBM, the history of trialed treatments, and the potential paths forward to target the pathway that may have greater success. 相似文献
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Junyuan Bai Xueyong Pang Xiangying Meng Hongbo Xie Hucheng Pan Yuping Ren Min Jiang Gaowu Qin 《材料科学技术学报》2020,(1):167-175
The crystal structure of the single-unit-cell thickness γ " phase,as a key strengthening phase in Mg-REZn(Ag) series alloys,has been extensively studied,and several structural models have been proposed in the past two decades.However,these reported models,and even the lattice constants at the same proposed structure,are scattered severely,which has led to considerable confusion and not available for further mechanical property simulation and prediction of Mg alloys containing this phase.In this study,by using first-principles calculations,the crystal structure of y" phase is clarified,resolving the discrepancies among different experiments,and its intrinsic mechanical properties have also been studied for the first time.It is verified that the γ " phase contains quasi-five atomic layers,instead of the previously reported tri-layer,and surprisingly,its crystal structure has many variants,which would change with the alloy composition.Besides,with the help of the simulated selected area electron diffraction(SAED) patterns,it is found that the atoms in the central layer remain partially ordered distribution,and this ordered extent primarily depends on the atomic ratio of RE:Zn(Ag) and the solute content in an alloy.That is,the ordered extent increases with decreasing the atomic ratio of RE:Zn(Ag) and/or increasing solute content of alloy,and vice versa.Ag and Zn dissolved in the γ" phase would produce almost opposed mechanical anisotropy for the γ " phase under the identical crystal structure,and the addition of Ag shows more efficient on increasing the shear modulus of γ" phase. 相似文献
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Fullerene decorated by iron compound (C60-Fe) is fabricated via solution reaction and characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), wide-angle X-ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). Upon incorporating C60-Fe into high-density polyethylene (HDPE) matrix by melt blending, the thermal and thermo-oxidative stability of HDPE are considerably increased, the oxidative induction time (OIT) is dramatically extend. When the concentration of C60-Fe reached 5 wt%, the onset degradation temperature in air increased from 352°C to 422°C, and the OIT dramatically delayed from 4.5 to 47.8 minutes. Moreover, from microscale combustion calorimetry (MCC), C60-Fe can reduce the peak heat release rate (PHRR), heat release capacity (HRC), and total heat release (THR) values of the composites, all of which are very important parameters for evaluating the fire retardancy of a polymeric material. 相似文献
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