Gaming on the move: urban experience as a new paradigm for mobile pervasive game design

In this paper, we describe a pervasive treasure hunting game: “Team exploration” based on the Transhumance mobile ad-hoc network platform. The testers of this game came up with innovative suggestions that combined the technical features of the platform with their urban experience. They pointed to specific aspects of urban mobility that influence pervasive game design and contribute to the user’s pleasure. These tests show that the notion of space (geometrical organization) is not enough to characterize and organize pervasive games and that four main anthropological features have to be taken into consideration: the concrete city (physical organization), the imaginary city (narratives), the functional city (services) and the city events. The multilayered urban experience is also defined by our schedules (including repetitive or exceptional events) and by our assessment of other users (the distance or proximity as they are felt). These diverse aspects and qualifications of urban experience provide an interesting framework for the understanding of pervasive game experimentations, as well as point to new directions in pervasive game design. Our paper advocates that further anthropological observations are part of the pervasive game design methodology.     

Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL-1

Drimane sesquiterpenoid dialdehydes are natural compounds with antiproliferative properties. Nevertheless, their mode of action has not yet been discovered. Herein, we demonstrate that various drimanes are potent inhibitors of MCL-1 and BCL-xL, two proteins of the BCL-2 family that are overexpressed in various cancers, including lymphoid malignancies. Subtle changes in their structure significantly modified their activity on the target proteins. The two most active compounds are MCL-1 selective and bind in the BH3 binding groove of the protein. Complementary studies by NMR spectroscopy and mass spectrometry analyses, but also synthesis, showed that they covalently inhibit MCL-1 though the formation of a pyrrole adduct. In addition, cytotoxic assays revealed that these two compounds show a cytotoxic selectivity for BL2, a MCL-1/BCL-xL-dependent cell line and induce apoptosis.     

Modelling adaptive management of intercropping in vineyards to satisfy agronomic and environmental performances under Mediterranean climate

In the Mediterranean area, rainfed viticulture is exposed to irregular rainfall distribution. The impacts on production and environment can be mitigated by appropriate management practices like, for instance, the introduction of cover crop in the inter-rows in vineyards. This paper presents the VERDI simulation model created to study various adaptive intercrop management strategies at field scale. The purpose is to design management strategies that are responsive to the water status of the biophysical system (soil – grapevine – intercrop) and the past and current climatic conditions. VERDI realistically reproduces the dynamic interactions between the biophysical system and the decision system in varying Mediterranean rain regime. The decision system works as an interpreter of a management strategy, defined as a set of soil surface management activities (e.g. mechanical weeding of the intercrop) that are linked by temporal constraints (e.g. sequencing, synchronisation) and organisational or programmatic specifications (e.g. iteration). The adaptive capabilities of the strategies are distinguished according to the different sources of flexibility to be exploited at operational, tactical, and strategic levels. A simulation study is reported that involves more or less flexible strategies under different climate scenarios. The simulation results proved that, in case of severe drought, the most flexible strategy yields the best trade-off between agricultural production and environmental services over the years.     

Electrolytic methanogenic-methanotrophic coupling for tetrachloroethylene bioremediation: proof of concept

Coupling of methanogenic and methanotrophic catabolisms was performed in a single-stage technology equipped with a water electrolysis cell placed in the effluent recirculation loop. The electrolysis-generated hydrogen served as an electron donor for both bicarbonate reduction into CH4 and reductive dechlorination, while the O2 and CH4, supported the cometabolic oxidation of chlorinated intermediates left over by the tetrachloroethylene (PCE) transformation. The electrolytical methanogenic/methanotrophic coupled (eMaMoC) process was tested in a laboratory-scale setup at PCE loads ranging from 5 to 50 micromol/L(rx) x d (inlet concentrations from 4 to 11 mg/L), and at various hydraulic residence times (HRT). Degradation followed essentially a reductive dechlorination pathway from PCE to cis-1,2-dichloroethene (DCE), and an oxidative pathway from DCE to CO2. PCE reductive dechlorination to DCE was consistently over 98% while a maximum oxidative DCE mineralization of 89% was obtained at a load of 4.3 micromol PCE/ L(rx) x d and an HRT of 6 days. Controlling dissolved oxygen concentrations within a relatively low range (2-3 mg/L) seemed instrumental to sustain the overall degradation capacity. Degradation kinetics were further evaluated: the apparent half-saturation constant (K(s)) had to be set relatively high (29 microM) for the simulated data to best fit the experimental ones. In spite of such kinetic limitations, the eMaMoC system, while fueled by water electrolysis, was effective in building and sustaining a functional methanogenic/methanotrophic consortium capable of significant PCE mineralization in a single-stage process. Hence, degradation standards are within reach so long as the methanotrophic DCE-oxidizing potential, including substrate affinity, are optimized and HRT accordingly adjusted.     

Geodynamic and seismic constraints on the thermochemical structure and dynamics of convection in the deep mantle

We revisit a recent study by Forte & Mitrovica in which global geophysical observables associated with mantle convection were inverted and the existence of a strong increase in viscosity near a depth of 2000 km was inferred. Employing mineral-physics data and theory we also showed that, although there are chemical anomalies in the lowermost mantle, they are unable to inhibit the dominant thermal buoyancy of the deep-mantle mega-plumes below Africa and the Pacific Ocean. New Monte Carlo simulations are employed to explore the impact of uncertainties in current mineral-physics constraints on inferences of deep-mantle thermochemical structure. To explore the impact of the high-viscosity peak at a depth of 2000 km on the evolution of lower-mantle structure, we carried out time-dependent convection simulations. The latter show that the stability and longevity of the dominant long-wavelength heterogeneity in the lowermost mantle are controlled by this viscosity peak.     

Can bipolar disorder-specific neuropsychological impairments in children be identified?

This study examined neuropsychological deficits among children with bipolar disorder while attending to its comorbidity with attention-deficit/hyperactivity disorder (ADHD). Seventy-three unmedicated children (ages 6-17 years) with Diagnostic and Statistical Manual of Mental Disorders (4th ed.; American Psychiatric Association, 1994) bipolar disorder plus ADHD (BPD + ADHD) were compared with 102 unmedicated children with ADHD without bipolar disorder, and 120 children without bipolar disorder or ADHD. Ninety-four percent of participants were Caucasian, 58% were male, and 42% were female. On average participants were of middle to upper socioeconomic status. Participants were assessed with a comprehensive neuropsychological battery and measures of academic achievement, school failure, and special education placement. Participants with BPD + ADHD and with ADHD were impaired in interference control, verbal learning, and arithmetic achievement and had higher rates of special school services. Across all of the measures of neuropsychological functioning, the only difference observed between youths with BPD + ADHD and youths with ADHD was that youths with BPD + ADHD performed more poorly on one measure of processing speed. Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder. (PsycINFO Database Record (c) 2010 APA, all rights reserved)