朝凯煤矿露天台阶爆破装药结构优化应用研究

本文以神达朝凯煤矿正在开采的台阶为工程背景,针对该矿在台阶爆破过程中存在着大块率高、根底多的现象,通过改变装药结构的方式对爆破参数进行优化。实践证明,优化后大块率和根底问题的治理效果明显。     

Efficient loading and entrapment of tamoxifen in human serum albumin based nanoparticulate delivery system by a modified desolvation technique

Herein, the poorly water-soluble drug, Tamoxifen (Tmx), was loaded in the amphipathic matrix of human serum albumin (HSA) nanoparticles by a modified desolvation method. In order to enhance the drug loading (DL) and drug entrapment efficiency (DEE) (<2% and 10%, respectively), ultrasonication of Tmx-HSA mixture was performed prior to desolvation process. Tmx loading and entrapment efficiency were optimized by employment of the response surface methodology (RSM)-central composite design (CCD) of experiments. Under the optimum conditions of 1.59 mg Tmx/ml concentration, 7.76 pH and 5 h incubation of HSA-Tmx, the DL of 6.7% and DEE of 74% are achievable. Particles with the average size of 195 nm, zeta potential of −21 mV and polydispersity index of 0.09 were produced under these conditions. A more sustained Tmx release behavior was observed from polyethylene glycol (PEG) conjugated nanoparticles in comparison to the non-PEGylated ones. The short-term stability investigation showed no alteration in physicochemical properties of nanoparticles at 4 and 37 °C, but small increase in nanoparticles size was observed after three months of storage at room temperature. This is the first report for efficient production of a Tmx delivery system based on HSA nanoparticles.     

Ti02／13X分子筛的合成、表征及催化脂肪氧化的研究

以钾长石与碳酸钠焙烧的热料为原料,经水热法合成13X型分子筛。进一步经溶胶一凝胶化过程和13X分子筛上负载TiO2以制稀TiO2／13X,并利用XRD、FTIR、SEM和EDS等对儿结构与性能进行表征。将13X和TiO2／13X用于催化脂肪氧化,测定氧化脂肪的过氧化值、p-茴香胺值和酸值,并以总钒化值和p-1茴香胺值作为反戍转化牢和选择性的评价参数,考察了催化剂的催化性能。结果表明,Ti／13X催化脂肪氧化的转化率和选择性者都远高于13X。此外,还研究了催化反应条件如温度、时间、空气流量等对催化反应的影响。     

刚壁气承轴心受压杆件的受力性能分析

为在受压杆件中充分利用材料的抗拉强度,提出一种新形式的杆件--刚壁气承轴心受压杆件,介绍杆件的结构形式,该杆件的主要特点为：杆件的轴心压力完全由内部高压气囊承受,约束刚壁不受压应力,稳定性好,承载力可调节。推导刚壁气承轴心受压杆件的承载力公式,并与薄壁圆管进行比较,表明刚壁气承轴心受压杆件具有很好的承载力,当长细比较大时,优势更加明显。以穹顶和射电望远镜结构为例,探讨刚壁气承轴心受压杆件在超大跨度结构和超高精度结构中的应用前景,结果表明：应用刚壁气承轴心受压杆件可以大幅度地降低结构自重,对于超高精度结构来说,还可通过对杆件充气或放气来主动调节杆件的承载力,随时补偿精度的损失,具有很好的应用前景与现实需求。     

Physicochemical properties of Ni-loaded yttrium stabilized zirconia nanotubes for solid oxide fuel cells

Yttrium-stabilized zirconia nanotubes (YSZNTs) were prepared using a conventional hydrothermal method, and their characteristics were compared with those of yttrium-stabilized zirconia nanoparticles (YSZNPs) synthesized in this study and with those of commercial YSZNPs (CYSZNPs). YSZNTs had widths and lengths of 20–30 nm and 100–700 nm respectively. The electrical conductivity of NiO (60.0 wt%)-loaded YSZNTs (40.0 wt%) was higher than those of NiO/YSZNPs and NiO/CYSZNPs at the same NiO loading. The zeta-potentials of YSZNTs in aqueous solution, determined by electrophoretic light scattering (ELS), indicated high positive surface charges at lower pH values, which is known to be related to surface stability, but negative values at high pH. The results of cyclic voltammetry (CV) and H₂-temperature-programmed reduction (H₂-TPR) confirmed that NiO(60.0 wt%)/YSZNTs (E_red = −0.445 mV) were more reduced than NiO/YSZNPs (E_red = −0.517 mV) and NiO/CYSZNPs (E_red = −0.516 mV).     

PHC桩在偏心荷载(横向位移)作用下的分析

本文根据材料力学原理和现行钢筋混凝土规范的规定,分析预应力混凝土管桩在偏心荷载作用下的内力和偏心距、偏心距与承载力的关系,以及偏心距的临界值等等,并对现行的预应力混凝土管桩规范谈谈个人的见解。分析结果表明:偏心承载明显地降低了桩的容许承载力,而且,桩在正常使用极限状态下所能容许的偏心距非常有限,这些特征应在预应力混凝土管桩的应用中慎重考虑。本文的分析方法可用于已产生横向位移桩的受力分析。     

竖向承载单桩优化设计及其准则法

提出了竖向承载单桩优化设计的数学模型及其求解的准则法 ,通过对均匀地基土层条件下的竖向受压桩与竖向抗拔桩的优化分析 ,说明竖向承载单桩优化设计方法可以应用于解决实际工程问题且经济效果明显     

弹塑性土体中竖向受荷单桩数值分析研究

建立了轴向受荷单桩有限元数值计算模型,利用广义Von Mises准则模拟土体的弹塑性,通过参数研究,对比了土的屈服准则的近似、剪胀性、初始自重应力及桩土界面的力学性状对单桩竖向承载力的影响。     

卷焊圆管、方管轴压杆的脆性屈曲

钢管截面构件受压时为脆性屈曲,可靠指标β与普通压杆理应有所不同,但目前国内有关设计规范(程)对此都没有反映。本文采用弹塑性梁柱理论、数值积分法计算了卷焊圆管、方管截面轴压杆完整的荷载-位移曲线,分析了纵向焊接残余应力、初弯曲、板件宽厚比(径厚比)对钢管压杆屈曲及屈曲后性能的影响,提出了圆管、方管截面轴压杆稳定承载力计算方法。