In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model

An improved glucose-chelator-albumin bioconjugate (GluCAB) derivative, GluCAB-2^Mal, has been synthesized and studied for in vivo ⁶⁴Cu-PET/CT imaging in breast cancer mice models together with its first-generation analogue GluCAB-1^Mal. The radioligand works on the principle of tumor targeting through the enhanced permeability and retention (EPR) effect with a supportive role played by glucose metabolism. [⁶⁴Cu]Cu-GluCAB-2^Mal (99 % RCP) exhibited high serum stability with immediate binding to serum proteins. In vivo experiments for comparison between tumor targeting of [⁶⁴Cu]Cu-GluCAB-2^Mal and previous-generation [⁶⁴Cu]Cu-GluCAB-1^Mal encompassed microPET/CT imaging and biodistribution analysis in an allograft E0771 breast cancer mouse model. Tumor uptake of [⁶⁴Cu]Cu-GluCAB-2^Mal was clearly evident with twice as much accumulation as compared to its predecessor and a tumor/muscle ratio of up to 5 after 24 h. Further comparison indicated a decrease in liver accumulation for [⁶⁴Cu]Cu-Glu-CAB-2^Mal.     

液体饮料PET无菌灌装工艺与装备研发进展

文章对目前液体饮料PET无菌灌装工艺与装备进行了归纳与总结，并对其研发趋势进行了展望，以期为液体饮料生产中PET无菌灌装技术的应用及优化提供相关依据。     

导热油在线再生装置的介绍与计算分析

聚酯工业中液相导热油在高温使用环境中会发生裂解甚至劣化的现象,从而影响导热油的使用性能。对劣化后的合成导热油的再生工艺流程进行了说明,提出了理论推导得到的导热油中低沸物质量分数、在线再生量、低沸物初始质量分数和再生批次之间的关系式。然后根据具体案例进行了导热油在线再生的计算分析,得出结论:导热油再生比更换导热油有较大的经济性优势;在导热油再生中确定合理的再生低沸物质量分数,能够以较小的能耗代价完成再生导热油的再生;另外选取适当大一点的单批次再生量,也有利于降低再生过程的能耗。     

18F-NaF注射液的制备及新西兰兔骨折显像

由外伤或肿瘤骨转移造成的隐匿性骨折和愈合情况的准确诊断对制定合适的治疗方案具有非常重要的意义。为考查¹⁸F-NaF PET显像用于骨折诊断的诊断效能，本研究制备了¹⁸F-NaF注射液，并对其进行了质量控制和稳定性研究，然后建立新西兰兔骨折动物模型，模型建立约2周后进行了¹⁸F-NaF PET显像和⁹⁹Tc^m-亚甲基二磷酸盐（⁹⁹Tc^m-MDP）SPECT显像的自身对照实验，并对显像效果进行了比较。结果表明：¹⁸F-NaF的产量大于37 GBq，各项检验结果均符合质控要求，40 ℃下放置8 h和30 ℃下放置10 h所有检验结果均无明显变化；¹⁸F-NaF PET和⁹⁹Tc^m-MDP SPECT两种显像方式均可见全身骨骼，骨折部位呈明显放射性浓聚，但¹⁸F-NaF给药后30 min即可进行PET显像，骨折部位显示更为清晰，骨折部位与对侧正常骨骼的放射性摄取比（T/NT）明显高于⁹⁹Tc^m-MDP，而⁹⁹Tc^m-MDP需在给药后2 h才能进行SPECT显像。本研究表明¹⁸F-NaF PET对骨折的显像性能优于⁹⁹Tc^m-MDP，可明显提高检查流通量和诊断效能。     

PET熔体长距离输送影响因素探讨

介绍了PET熔体长距离输送工艺流程,重点分析易对PET熔体输送带来不利影响的因素,如熔体压力降、停留时间、管道粗糙度、焊缝品质等,并针对熔体输送的不利因素,提出了相应的解决方案,对熔体直纺设计、实践提供必要的参考。     

Dynamic viscoelasticity and molecular orientation in uniaxially drawn PC/PET blends

The dependence of dynamic viscoelasticity on molecular orientation of the hot-drawn polycarbonate (PC)/poly(ethylene terephthalate) blends was studied experimentally. The oriented states of samples were investigated by wide-angle X-ray diffraction and quantified by Hermans' factor. The viscoelasticity was probed by dynamic mechanical analysis. For the fitting curves of dynamic modulus versus orientation, the PC-rich blends with different compositions had an opposite concavity and convexity compared with the neat PC. The difference revealed the influence of molecular mobility on orientation and viscoelasticity. The assumption on the phase morphological change from sea-island to local sandwich-like structure in blends was proposed and used to interpret the variation of slope of fitting curves. The relationship between orientation and viscoelasticity was observed in PC-rich blends, which can help understand the mechanism of molecular orientation and develop the constitutive relations for simulation. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47514.     

Self-doped N-propansulfonic acid polyaniline-polyethylene terephthalate film used as active sensor element for humidity or gas detection

In this work, we report the fabrication of sensors’ element for humidity or gases, prepared by in situ polymerization of aniline N-propansulfonic acid using ammonium persulfate in acidic medium. The polymer is being used in the form of powder or deposited in multiple layers onto the PET film. Various techniques including Fourier Transform infrared (FTIR), ultraviolet-–visible spectroscopy (UV–vis), X-ray diffraction (XRD) and scanning electron microscopy (SEM) were employed to characterize the as-prepared sensing materials. The film has been tested for humidity influence, where the significant variations in electrical characteristics were observed, suggesting its usefulness for humidity sensors. Also, for different organic and inorganic gases, a relatively low operating temperature and important sensitivity were observed that indicate its applicability as an active element for general gases sensors. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47743.     

Poly(ethylene terephthalate)/poly(ethylene glycol‐co‐1,3/1,4‐cyclohexanedimethanol terephthalate)/clay nanocomposites: Mechanical properties,optical transparency,and barrier properties

Poly(ethylene terephthalate) (PET)/clay, PET/poly(ethylene glycol‐co‐1,3/1,4‐cyclohexanedimethanol terephthalate) (PETG), and PET/PETG/clay nanocomposites were fabricated using the twin‐screw extrusion technique. The spherulitic morphologies, thermomechanical, mechanical, and gas‐barrier properties, as well as the effect of clay on the transparency of the resulting nanocomposites were identified. The clay induced the heterogeneous nucleation of the nanocomposites during the cold crystallization process, thereby increasing the crystallinities and melting temperatures of the resulting nanocomposites. The incorporation of clay increased the storage moduli, Young's moduli, impact strengths, and barrier properties of the PET, PETG, and PET/PETG blend. Regarding the optical transparency, the inclusion of clay can make the crystallizable PET matrix crystalline opaque. However, the amorphous PETG maintained its transparency. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 39869.     

Atom transfer radical polymerization (ATRP): A versatile and forceful tool for functional membranes

The progress in atom transfer radical polymerization (ATRP) provides an effective means for the design and preparation of functional membranes. Polymeric membranes with different macromolecular architectures applied in fuel cells, including block and graft copolymers are conveniently prepared via ATRP. Moreover, ATRP has also been widely used to introduce functionality onto the membrane surface to enhance its use in specific applications, such as antifouling, stimuli-responsive, adsorption function and pervaporation. In this review, the recent design and synthesis of advanced functional membranes via the ATRP technique are discussed in detail and their especial advantages are highlighted by selected examples extract the principles for preparation or modification of membranes using the ATRP methodology.     

聚对苯二甲酸乙二醇酯/聚丙二醇共聚醚酯热性能研究

采用熔融缩聚法制备了聚对苯二甲酸乙二醇酯/聚丙二醇共聚醚酯（PET/PPG）,并采用核磁共振氢谱（1H-NMR）、热重分析（TGA）、差示扫描量热分析（DSC）、动态热分析（DMA）等研究了材料的结构与热性能,1H NMR结果证明了PET/PPG共聚物结构的存在,而且共聚物的组成与投料比非常接近;热分析的结果表明,聚醚链段的引入对热稳定性和熔融温度的影响不大,而玻璃化转变温度、冷结晶温度、冷结晶焓、储能模量、损耗正切的峰温均有明显下降.