液相色谱-串联质谱技术在临床检验中的应用研究进展

液相色谱-串联质谱（LC-MS/MS）技术具有高灵敏度、高特异性、高分辨率和高效率的优点。近年来随着仪器灵敏度的提高，LC-MS/MS在常规临床检验中显示出极大的潜力，并在疾病早期预防和诊断中发挥着不可替代的作用。本文对LC-MS/MS在新生儿疾病筛查、维生素D检测、内分泌激素检测、肽类和蛋白质定量分析等临床检验方面的研究进展进行综述，并讨论了未来面临的挑战。     

减水剂类型对赤泥—矿渣基地聚物注浆材料性能的影响及机理研究

针对赤泥等固体废弃物对环境危害性大且利用率低等问题,以碱激发赤泥-矿渣基地聚物注浆材料为 研究对象,研究了不同掺量的聚羧酸(PA)减水剂、醛酮缩合物(AKC)减水剂和萘系(N)减水剂对材料凝结时间、流动 性及强度等的影响,并通过 XRD、傅里叶红外光谱及 SEM 等设备对减水剂的作用机理进行研究。 结果表明:减水剂增 强了材料的流动性但降低了材料的剪切应力;N 和 PA 减水剂能缩短材料的凝结时间,但 AKC 减水剂会延长材料的凝 结时间;N 和 AKC 减水剂能提高材料的强度,但 PA 减水剂会降低材料的强度;N 减水剂对材料的综合性能提升效果 更加明显,其最优掺量为 0. 7%;减水剂对赤泥-矿渣基地聚物性能提升的作用机理主要是促进地聚合物凝胶的形成。 研究成果为拓展赤泥在工程上的使用途径和效率提供了理论指导。     

2.3–21 GHz broadband and high linearity distributed low noise amplifier

This paper focuses on the design of a 2.3–21 GHz Distributed Low Noise Amplifier (LNA) with low noise figure (NF), high gain (S₂₁), and high linearity (IIP3) for broadband applications. This distributed amplifier (DA) includes S/C/X/Ku/K-band, which makes it very suitable for heterodyne receivers. The proposed DA uses a 0.18 μm GaAs pHEMT process (OMMIC ED02AH) in cascade architecture with lines adaptation and equalization of phase velocity techniques, to absorb their parasitic capacitances into the gate and drain transmission lines in order to achieve wide bandwidth and to enhance gain and linearity. The proposed broadband DA achieved an excellent gain in the flatness of 13.5 ± 0.2 dB, a low noise figure of 3.44 ± 1.12 dB, and a small group delay variation of ±19.721 ps over the range of 2.3–21 GHz. The input and output reflection coefficients S₁₁ and S₂₂ are less than −10 dB. The input compression point (P_1dB) and input third-order intercept point (IIP3) are −1.5 dBm and 11.5 dBm, respectively at 13 GHz. The dissipated power is 282 mW and the core layout size is 2.2 × 0.8 mm².     

生物标志物在生物药临床研究中的应用及生物分析策略

中国生物药研发进入快车道，新药研发费用不断攀升，但并没有提高药物上市的成功率，因此亟需对药物研发模式进行转变。为了提高药物研发成功率，以生物标志物为核心的转化医学新药研发模式被普遍接受。本文综述了以生物标志物为核心的转化医学新药研发思路，生物标志物在生物药临床研究中的应用，生物标志物生物分析策略，生物标志物在生物药临床研究中的机遇与挑战。通过对标国际，寻找中国优势，从生物标志物为立足点的转化医学研发模式寻找机遇，中国可以尽早做成具有全球影响力的创新药。     

中医药临床研究电子数据管理特点及标准操作规程的制定

电子数据管理具有节约成本、缩短研发周期、提高数据质量等优势,已逐步成为临床研究数据采集与管理的主流形式,规范开展电子数据管理工作是提高中医药临床研究质量的重要措施。本文介绍了临床研究电子数据管理标准操作规程(standard operating procedure, SOP)的作用、制定原则、一般体例、制定流程、SOP的管理与培训以及实际工作中常用的SOP,最后讨论了中医药临床研究电子数据管理的特点及难点,并给出了建议的解决措施。     

森林抚育对森林生态系统的影响

伴随着我国社会经济的稳固发展,人们的生活质量逐渐有了明显改善,而在生态问题趋于严重使人们的环境保护意识显著提高的过程中,森林抚育对于森林生态系统的作用和价值愈发凸显。对此,文章针对森林抚育,从提高森林利用率、维持森林动植物生态平衡、增加可利用水资源等多个方面就其对森林生态系统的影响进行了分析,旨在给予相关森林保护工作者可行的帮助,并以此促进我国森林开发工作的可持续发展。     

中国废钢资源发展战略研究

 为提高中国钢铁工业的废钢比,推动钢铁工业的绿色发展,分析了中国废钢资源的概况、废钢行业技术发展现状和钢铁工业废钢利用的现状,并对中国未来废钢资源量进行预测。在此基础上,针对中国废钢资源的发展提出了3条战略判断和6条政策建议。     

道在山林，周弥六合——浙东天台山“洞天福地”的山岳景观流变及文化意象研究

道教洞天福地作为中国名山风景的经典类型之一，在宗教山岳景观中占据独特地位。浙东天台山水神秀，历代高道以入山隐修为主要目的，形成了道教在区域山林的景观文化基础。从天台山“神仙之乡”的文化背景出发，从“想象与实践”的视角切入，梳理了天台山洞天福地的景观流变：分析其“不死之福庭”地域性景观的形成经历了“赤城→桐柏”的信仰转移过程；以天台山为坐标，洞天福地格局打破了区域“层级”分布特征，而呈现大范围“州郡”空间格局。作为“联结点”的天台山，洞天世界沟通了宇宙、山、人3个基本场域，由此衍生出“洞宫”式和“周回”式山岳空间营建典范。旨在挖掘洞天福地中典型案例的价值，为中国洞天福地体系的构建提供理论依据。     

Rethinking Enterprise Architecture for Sustainable Energy System Development

The development of a sustainable energy system throughout an enterprise is a complex task, which requires an agile holistic approach. Such an approach needs to include a variety of objectives including energy strategy formation and strategic decision-making, which are directly related to the analysis and management of the main areas of sustainable development:The economic, technological, environmental, and social. These multidimensional requirements of sustainability are often difficult to achieve within the enterprise, because these aspects are interrelated and influenced by various internal and external environment factors. This paper first reviews the main challenges for an energy system, and then demonstrates how a strategic agile enterprise architecture driven approach could effectively guide the sustainable energy system development. The study presented in this paper provides a holistic approach that contributes to the advancement and usage of literature dealing with issues of sustainable energy system development and agile enterprise architecture, which has not been discussed before to any great extent.     

Resistive switching characteristics of ZnO–graphene quantum dots and their use as an active component of an organic memory cell with one diode-one resistor architecture

We investigated the resistive switching characteristics of a polystyrene:ZnO–graphene quantum dots system and its potential application in a one diode-one resistor architecture of an organic memory cell. The log–log I–V plot and the temperature-variable I–V measurements revealed that the switching mechanism in a low-current state is closely related to thermally activated transport. The turn-on process was induced by a space-charge-limited current mechanism resulted from the ZnO–graphene quantum dots acting as charge trap sites, and charge transfer through filamentary path. The memory device with a diode presented a ∼10³ I_ON/I_OFF ratio, stable endurance cycles (10² cycles) and retention times (10⁴ s), and uniform cell-to-cell switching. The one diode-one resistor architecture can effectively reduce cross-talk issue and realize a cross bar array as large as ∼3 kbit in the readout margin estimation. Furthermore, a specific word was encoded using the standard ASCII character code.