2种侧围加强内框总成检具结构对比分析

概述了侧围加强内框总成与周边零件的匹配关系,从检具操作的人机工程出发,描述了侧围加强内框总成检具的2种定位方式和结构设计,对比了2种定位方式对于检测结果的影响,总结了其优点和弊端,结果表明侧围加强内框总成检具采用车内方向朝下的定位方式效果更好。     

Lake charr (Salvelinus namaycush) clotting response may act as a plasma biomarker of sea lamprey (Petromyzon marinus) parasitism: Implications for management and wound assessment

Sea lampreys (Petromyzon marinus) have decimated the Great Lakes fisheries over the past century, and their control is central to protecting native fish populations. Wounding data collected from host fish, including classifying wounds as Type A (penetrating the integument) or Type B (superficial), is an integral part of sea lamprey monitoring efforts and helps inform management decisions; however, wound assessment is subjective and error-prone. This study aimed to determine if protein biomarkers of parasitism could be quantified in host fish plasma to serve as a potential objective aide in current wound assessment practices. Male siscowet lake charr (Salvelinus namaycush) were parasitized in a lab setting for four days, after which the sea lamprey was removed, host blood was collected, and the wound Type recorded. A second blood sample was collected from host fish with Type A wounds 7 months later. The plasma proteome was quantified using iTRAQ, and the relative abundances of 169 proteins were compared between parasitized and non-parasitized control fish. Three functional classes of proteins were modified by sea lamprey parasitism: immune response, lipid transport, and blood coagulation. A major finding was evidence of a concerted anticoagulation response in fish with Type A wounds, including changes in protein components and regulators of fibrin clot formation, some of which did not fully recover within 7 months. A modified clotting assay yielded a smaller thrombin-induced fibrin clot from parasitized fish, supporting the proteomic results. Therefore, measuring blood clottability could improve sea lamprey damage estimates by providing a more objective and quantitative index of parasitism than is offered by wounding data alone.     

Design,Synthesis, and in vitro Evaluation of P2X7 Antagonists

The P2X7 receptor is a promising target for the treatment of various diseases due to its significant role in inflammation and immune cell signaling. This work describes the design, synthesis, and in vitro evaluation of a series of novel derivatives bearing diverse scaffolds as potent P2X7 antagonists. Our approach was based on structural modifications of reported (adamantan-1-yl)methylbenzamides able to inhibit the receptor activation. The adamantane moieties and the amide bond were replaced, and the replacements were evaluated by a ligand-based pharmacophore model. The antagonistic potency of the synthesized analogues was assessed by two-electrode voltage clamp experiments, using Xenopus laevis oocytes that express the human P2X7 receptor. SAR studies suggested that the replacement of the adamantane ring by an aryl-cyclohexyl moiety afforded the most potent antagonists against the activation of the P2X7 cation channel, with analogue 2-chloro-N-[1-(3-(nitrooxymethyl)phenyl)cyclohexyl)methyl]benzamide ( 56 ) exhibiting the best potency with an IC₅₀ value of 0.39 μM.     

公民水素养评价表征因素模型构建与分析

针对我国水资源紧缺、水生态损害、水环境污染等相关水问题,以提升全民爱水惜水节水护水的意识和能力为目标,从水素养概念出发,通过扎根理论质性研究方法对公民水素养评价的表征因素进行筛选和提炼,最终得出包含水知识、水态度、水行为为主范畴的10个表征因素并运用解释结构模型(ISM)深入剖析各因素之间的内在联系。在此基础上建立了3级多层次递阶结构模型,进一步精确描述系统各要素两两之间的直接关系。结果表明:公民水素养评价的表征因素自上而下形成了表象层、中间层和根源层等3个层级,可直观、清晰地反映表征因素之间的递阶、层级关系;水态度在各表征因素中具有调节作用以及各表征因素之间存在内在逻辑关系。研究成果为提高公民水素养水平提供一定的科学依据和政策参考。     

Muddling between science and engineering: an epistemic strategy for developing human factors and ergonomics as a hybrid discipline

Human Factors and Ergonomics (HFE) recognises itself as a design-driven, systemic and scientific discipline geared towards well-being and performance. Being a scientific discipline and design-oriented requires that the epistemic basis of science and design/engineering be fully comprehended. In interdisciplinary research where these two viewpoints meet, there are often dilemmas posed in terms of knowledge construction and labelling of activity. Therefore, this article scrutinises these two orientations and addresses the differences and commonalities, using case studies from engineering and psychological science (both constituents of HFE). Based on these insights, a way forward is suggested in terms of (1) a reflexive engagement with epistemic concepts and methods; (2) finding a conceptual space for balancing and bridging the science-engineering divide; (3) comprehending ‘design-thinking/design knowledge’ and not treating it as an application of science; (4) providing emphasis on problem formulation and practices of HFE focusing on developing them in systemic terms.     

Sequence-Dependent Nanofiber Structures of Phenylalanine and Isoleucine Tripeptides

The molecular design of short peptides to achieve a tailor-made functional architecture has attracted attention during the past decade but remains challenging as a result of insufficient understanding of the relationship between peptide sequence and assembled supramolecular structures. We report a hybrid-resolution model to computationally explore the sequence–structure relationship of self-assembly for tripeptides containing only phenylalanine and isoleucine. We found that all these tripeptides have a tendency to assemble into nanofibers composed of laterally associated filaments. Molecular arrangements within the assemblies are diverse and vary depending on the sequences. This structural diversity originates from (1) distinct conformations of peptide building blocks that lead to different surface geometries of the filaments and (2) unique sidechain arrangements at the filament interfaces for each sequence. Many conformations are available for tripeptides in solution, but only an extended β-strand and another resembling a right-handed turn are observed in assemblies. It was found that the sequence dependence of these conformations and the packing of resulting filaments are determined by multiple competing noncovalent forces, with hydrophobic interactions involving Phe being particularly important. The sequence pattern for each type of assembly conformation and packing has been identified. These results highlight the importance of the interplay between conformation, molecular packing, and sequences for determining detailed nanostructures of peptides and provide a detailed insight to support a more precise design of peptide-based nanomaterials.     

Data envelopment analysis based on team reasoning

Existing approaches to data envelopment analysis focus mainly on the derivation of the efficiency of the individual decision‐making unit (DMU) or on the calculation of the weights of multiple inputs or outputs, but pay little attention to the team interest of all the DMUs. Motivated by the idea of team reasoning, in which the benefit of the team is of higher importance than that of each individual, this paper considers all the DMUs as a team and introduces the team indexes including the overall efficiencies, variance, boundaries of all the DMUs, and relationships between DMUs. Several models are first developed to estimate values of the team indexes based on which decision makers can provide their preferences regarding them. Then, models are established to obtain the interval efficiencies of individual DMUs under the condition that the team indexes are satisfied. Several examples are given to illustrate the proposed approaches and verify their applicability.     

Olfactory responses of Stegobium paniceum to different Chinese medicinal plant materials and component analysis of volatiles

Stegobium paniceum (L.) (Coleoptera: Anobiidae) is among the major pests of stored products, causing great damage to stored Chinese medicinal plant materials (CMPMs) in China. Effective control strategies are urgently needed. The aim of this study was to explore the role of volatile organic compounds in the host preference of S. paniceum. First, the olfactory behavioral responses of S. paniceum adults to volatiles from four CMPMs (Panax notoginseng, Angelica sinensis, Gastrodia elata, and Peucedanum praeruptorum) were tested in Y-tube olfactometer experiments. Then, the volatile composition of these plant materials were analyzed by gas chromatography-mass spectrometry (GC-MS). S. paniceum showed significant preferences for volatiles from the four CMPMs, compared with clean air (CA). When S. paniceum was presented with choices among different CMPMs, it showed the strongest preference for P. notoginseng, followed by A. sinensis, then G. elata, and P. praeruptorum. GC-MS analysis identified 43, 34, 28 and 60 components in the volatile profiles of P. notoginseng, A. sinensis, G. elata, and P. praeruptorum, respectively. Falcarinol (14.4%), 3-n-butyl phthalide (78.7%), p-cresol (40.1%), and β-pinene (29.1%) were the most abundant components of the volatiles of P. notoginseng, A. sinensis, G. elata, and P. praeruptorum, respectively. The olfactory responses of S. paniceum to the four CMPMs demonstrated that host-related volatiles play an important role in the host-searching process by adult beetles. This information will be useful for the development of safe and effective trapping strategies for this pest.