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《Ceramics International》2021,47(23):32963-32968
Effects of carbon source in single-source ZrC-based liquid precursors on the properties of the precursors and precursor-derived nano ZrC powders were investigated. The liquid precursors were prepared by directly blending and heating zirconium n-butoxide with either 2,4-pentanedione, benzoyl acetone or 1,3-diphenyl-1,3-propanedione additives which have the same chemical composition and structure except for the number of benzene rings (0, 1 and 2, respectively) in order to control the carbon content in the precursors. The ceramic yield of the precursor decreased as the number of benzene rings in the precursors increased. The stability of the precursors in air and the carbon content of the ceramic powder increased when using 1,3-diphenyl-1,3-propanedione additive. X-ray pure nano zirconium carbide powders with ultra-fine size (30 nm), isotropic shape and homogeneous particle size distribution were synthesized from the liquid precursors containing two benzene rings in the structure. Compared with ZrC powders derived from the precursors containing zero or one benzene ring, the powder from the precursor containing two benzene rings was finer and more homogeneous in size distribution. 相似文献
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Friederike Freiin von Hvel Ekaterini Kefalakes Claudia Grothe 《International journal of molecular sciences》2021,22(1)
Fibroblast growth factor 2 (FGF-2), ubiquitously expressed in humans and mice, is functionally involved in cell growth, migration and maturation in vitro and in vivo. Based on the same mRNA, an 18-kilo Dalton (kDa) FGF-2 isoform named FGF-2 low molecular weight (FGF-2LMW) isoform is translated in humans and rodents. Additionally, two larger isoforms weighing 21 and 22 kDa also exist, summarized as the FGF-2 high molecular weight (FGF-2HMW) isoform. Meanwhile, the human FGF-2HMW comprises a 22, 23, 24 and 34 kDa protein. Independent studies verified a specific intracellular localization, mode of action and tissue-specific spatiotemporal expression of the FGF-2 isoforms, increasing the complexity of their physiological and pathophysiological roles. In order to analyze their spectrum of effects, FGF-2LMW knock out (ko) and FGF-2HMWko mice have been generated, as well as mice specifically overexpressing either FGF-2LMW or FGF-2HMW. So far, the development and functionality of the cardiovascular system, bone formation and regeneration as well as their impact on the central nervous system including disease models of neurodegeneration, have been examined. This review provides a summary of the studies characterizing the in vivo effects modulated by the FGF-2 isoforms and, thus, offers a comprehensive overview of its actions in the aforementioned organ systems. 相似文献
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基于CFD?DEM耦合方法,研究了颗粒在水室内的流动状态,分析了不同刀盘转速、粒子水通入量和水室出口角度对造粒过程的影响,发现提高刀盘转速、增加粒子水通入量和水室出口倾斜一定的角度都有利于水室内颗粒的排出。进一步研究了颗粒与碎屑在水室内的流动,发现在水室出口处二者的流动基本呈现出一定的分离角度。 相似文献
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Benedetta Russo Marika Menduni Patrizia Borboni Fabiana Picconi Simona Frontoni 《International journal of molecular sciences》2021,22(10)
The role of the autonomic nervous system in obesity and insulin-resistant conditions has been largely explored. However, the exact mechanisms involved in this relation have not been completely elucidated yet, since most of these mechanisms display a bi-directional effect. Insulin-resistance, for instance, can be caused by sympathetic activation, but, in turn, the associated hyperinsulinemia can activate the sympathetic branch of the autonomic nervous system. The picture is made even more complex by the implicated neural, hormonal and nutritional mechanisms. Among them, leptin plays a pivotal role, being involved not only in appetite regulation and glucose homeostasis but also in energy expenditure. The purpose of this review is to offer a comprehensive view of the complex interplay between leptin and the central nervous system, providing further insights on the impact of autonomic nervous system balance on adipose tissue and insulin-resistance. Furthermore, the link between the circadian clock and leptin and its effect on metabolism and energy balance will be evaluated. 相似文献
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西湖凹陷中部西斜坡地区超压成因机制 总被引:10,自引:5,他引:5
沉积盆地超压成因研究已取得了重要进展,关于超压主要成因的认识也发生了重要变化,以往一些被普遍认为属于典型不均衡压实成因的超压已被部分或完全否定,生烃作用作为超压成因的普遍性得到愈来愈多的证实。西湖凹陷多个构造带的不同层位均发育超压,目前认为超压的形成仍然离不开不均衡压实(欠压实作用)的贡献。根据异常压力形成的基本地质条件和异常压力产生的地质、地球物理效应两方面因素,利用测井曲线组合分析法、鲍尔斯法(加载-卸载曲线法)、声波速度-密度交会图法、孔隙度对比法、压力计算反推法以及综合分析法系统解剖分析了西湖凹陷中部西斜坡地区平湖组不同岩性异常压力成因。研究结果表明:西湖凹陷中部西斜坡泥岩中烃源岩超压主要为自源生烃增压,非烃源岩超压为邻源压力传导成因。储层中至少存在常压-超压型和常压-超压-常压型两种压力结构类型,异常压力自南向北顶界面逐渐变深,主要为油气在生烃增压驱动下向储层运移过程中的压力传导所致。 相似文献
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For industrial chemical process, preliminary-summation-based principal component analysis (PS-PCA), an amended PCA method was recently provided for coping with both Gaussian and non-Gaussian characteristics. By summing the training and monitoring data respectively, PS-PCA is capable of resolving the issue of non-Gaussian processes and achieves higher fault detection rate than the traditional PCA. However, in the PS-PCA summation operation, all data samples are regarded as the same weight, which results in the fault information of newly-samples may be diluted, leading to significant detection delays. To address this challenge, in this paper, we propose a novel weighted PS-PCA (WPS-PCA) method that employs an exponential weighting scheme to put more emphasis on recent information. Subsequently, a mathematical argument demonstrates that when the number of variables is enough plentiful, the obtained summation combined with the generalized central limit theorem conforms to approximately a Gaussian distribution. The kurtosis relationships indicate this conversion will bring out well-pleasing feasibility for conventional PCA. Ultimately, the proposed technique verifies detection performance using the Tennessee Eastman process, which is compared with the existing PCA and PS-PCA schemes, in terms of the fault detection time and fault detection rate. The simulation studies reveal that the proposed method is efficient and superior. 相似文献
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