Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies

Opioids are the drugs of choice in severe pain management. Unfortunately, their use involves serious, potentially lethal side effects. Therefore, efforts in opioid drug design turn toward safer and more effective mechanisms, including allosteric modulation. In this study, molecular dynamics simulations in silico and ‘writhing’ tests in vivo were used to characterize potential allosteric mechanism of two previously reported compounds. The results suggest that investigated compounds bind to μ opioid receptor in an allosteric site, augmenting action of morphine at subeffective doses, and exerting antinociceptive effect alone at higher doses. Detailed analysis of in silico calculations suggests that first of the compounds behaves more like allosteric agonist, while the second compound acts mainly as a positive allosteric modulator.     

Colored apparel and its potential influence on heterosexual attraction

The objective of this study is to determine if men would follow the “red effect” when choosing colors for women to wear on a date, and also to determine if the colors that men would wear when going on a date would be the same as the colors that females (their date) would wish them to wear. A set of psychophysical data was generated from this experiment, where participants were asked to rank a set of 10 colored samples based on preference for each question asked. There were three different sets of colored samples. The set of colored samples given to the participant depended on the question. A total of five questions were asked. Scaling analysis was done on the data to organize a set of items according to preferences providing values, an interval scale (Z values), that correspond to the relative perceptual differences among the stimuli. The Z values were graphed to show the general preference of colors for women to wear, and the preference of colors for men to wear. A Spearman's rank-order correlation coefficient (SRCC) was calculated comparing each individual's rank order with the mean rank order for that specific question. An average Spearman's rank order was calculated for each question and each gender in order to determine the variability in answers. Scaling results indicate that men follow the “red effect,” but women preferred to wear other colors such as turquoise, blue, or yellow depending on the outfit. Males and females agreed that no matter the colored bottoms (denim or black), blue was the preferred color top for men to wear. SRCC results showed a lot of variability between individual answers and the mean answer indicating that participants' rankings did not necessarily agree with general color preferences presented in the scaling analysis. While scaling analysis might suggest certain color preferences such as men following the “red effect” and women preferring to wear blue, the poor correlation found using SRCC between the individual answers and the mean rank orders suggests that color preferences for each individual are inherently unique.     

基于视觉暗示的战争纪念建筑设计手法探究

当代建筑中，视觉暗示的设计手法对纪念建筑的营造有着至关重要的作用。现试图从建筑学的视角出发，以当代战争纪念建筑实际案例为研究对象，对战争纪念建筑的设计方法展开讨论。首先着重分析视觉暗示与格式塔心理学的关系，其次阐述视觉暗示给参观者心理带来的微妙变化，之后探讨视觉暗示对空间纪念效果造成的影响，最终归纳为可操作的设计策略：图形暗示、内容暗示、秩序暗示，并明确其如何相互影响。立足于格式塔心理学及心理暗示的理论基础，是对纪念建筑设计方法的补充，亦可为今后的战争纪念馆设计提供启示。     

智能网联汽车APP中控制模块的视觉设计与应用

目的研究智能网联汽车手机APP中控制模块的视觉设计与应用,强化视觉设计过程的合理性,为智能汽车HMI设计实践工作提供启示与借鉴。方法首先从用户体验的角度分析APP控制模块存在的视觉设计问题,主要是视觉结构单一、视觉层级混乱、视觉特征缺失,再从行为逻辑的角度思考视觉设计方法,"由面及点"地提出控制模块的视觉设计思路,并结合设计应用案例论证其可行性。结果从合理视觉布局、明确视觉层级和提炼视觉语言的角度提出APP控制模块的视觉设计思路。结论智能网联汽车APP控制模块的视觉设计应该重视行为逻辑的影响。从任务角度思考视觉布局、从行为逻辑的角度思考视觉层级、从行为特征的角度思考视觉语言,提高视觉设计工作的合理性,减少与交互设计工作脱节的现象,强化控制求助的高效性和安全性。     

Virtual shopping and unconscious persuasion: The priming effects of avatar age and consumers’ age discrimination on purchasing and prosocial behaviors

This study examined how operating elderly or young avatars affected shoppers’ product perceptions and purchasing behaviors. It also investigated how virtual shopping experiences translated into prosocial behavior regarding a nonprofit organization supporting the elderly. Operating elderly avatars influenced shoppers’ product choice and walking speed while shopping compared to operating younger avatars. In addition, operating elderly avatars positively affected participants’ attitudes and willingness to donate to and volunteer for a nonprofit organization supporting the elderly. Statistical interactions between avatar age and a shopper’s ageism on behavioral and persuasion outcomes were also confirmed, and these findings implied an assimilation/contrast effect influenced by a shopper’s preexisting prejudices toward the elderly.     

视觉心理学在住宅室内设计中的应用浅谈

论文将视觉心理学与住宅室内设计相结合，通过具体案例分析视觉心理学在室内设计中的应用。     

工程项目可持续发展政策有效性的行为经济学分析

工程项目由于消耗的大量的能源和资源,因此带来环境极大的负荷,如何实现项目的可持续发展越来越受到政府的重视。本文结合有限理性理论的预期理论、认知的不协调、信息的显著性理论和可见惯性,分析了在有限理性下,行为经济学影响政策有效性的潜在原因。最后对政策的制定提出了应该明确的方向和侧重点。     

从本体分析入手探索铁路客站设计方法

基于“以人为本”的思想,利用环境和运输心理学理论分析了旅客出行的行为活动和心理状态,针对客运的实际情况提出客站设计的理念,目的在于改善环境和流程及服务手段以满足旅客的功能需求和精神需求,不断完善客站设计理论,从而推动铁路客站建设的现代化.     

城市照明的环境理念

通过对人类环境构成的分析，应用环境心理学方法，阐明了影响城市照明的人、光、物等环境要素及其关系，在研究人的视觉特点和心理需求的基础上，总结了城市总体、城市广场、建筑物、园林景区等要素的照明特点，揭示了城市照明环境的规律，建构了绿色照明的理论体系。研究发现城市照明不仅是从技术上营造视觉环境，更要通过城市的空间要素和人的生理感知的相协调，以营造与功能氛围相和谐的心理环境。最后，从基于环境理念出发，提出了综合自然条件、物体形态、人眼视觉、光学特性和环境特色的城市照明设计思路。