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1.
Dr. Ying Wang Prof. Dr. Andrew Ewing 《Chembiochem : a European journal of chemical biology》2021,22(5):807-813
Exocytosis plays an essential role in the communication between cells in the nervous system. Understanding the regulation of neurotransmitter release during exocytosis and the amount of neurotransmitter content that is stored in vesicles is of importance, as it provides fundamental insights to understand how the brain works and how neurons elicit a certain behavior. In this minireview, we summarize recent progress in amperometric measurements for monitoring exocytosis in single cells and electrochemical cytometry measurements of vesicular neurotransmitter content in individual vesicles. Important steps have increased our understanding of the different mechanisms of exocytosis. Increasing evidence is firmly establishing that partial release is the primary mechanism of release in multiple cell types. 相似文献
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ABSTRACT Supply chains are becoming increasingly complex, and many companies and researchers are looking to nature for finding solutions. In this paper, we provide a narrative synthesis and systematic review to explore state-of-the-art, and identify key areas for exploration of nature inspired solutions in the supply chain area. We consider strategic, tactical, and operational decisions within supply chains and identify analogies between biological systems and supply chains to create a new research agenda. Our findings show that the majority of the research in nature inspired supply chains from the systemic perspective focuses on closed loop supply chains. In contrast, similar systemic solutions such as industrial symbiosis, circular economy, and industrial ecology have not been explored as frequently. Reducing production waste (industrial symbiosis) in addition to end-of-life product waste (closed loop supply chains), optimising raw material use and extending the life of used resources (circular economy), investigating the interactions between biosphere and technosphere (industrial ecology), and seeking solutions to industrial problems from nature (biomimicry) are all possible paths for reaching a zero-waste economy. These systemic solutions have a considerable impact on the supply chains at the strategic, tactical, and operational levels, which need to be explored to identify efficient and effective solutions. 相似文献
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对我国常用的闭口闪点测定方法宾斯基-马丁闭口杯法、阿贝尔闭口杯法和泰格闭口杯法的测定原理进行对比分析,并采用这3种方法分别对2种有证标准样品、4种有机试剂样品和7种喷气燃料样品的闭口闪点进行测定。结果表明:这3种方法在适用范围、仪器结构、升温速率和点火操作要求等方面都有一定差异,导致采用这3种方法测定同一样品的闭口闪点结果略有差异,闪点测定结果之间的最大差值与样品闪点的高低呈正相关;与阿贝尔闭口杯法相比,宾斯基-马丁闭口杯法测得的闪点结果较高,对于3号喷气燃料,二者之差为0~1.0 ℃,阿贝尔闭口杯法更适合3号喷气燃料闭口闪点的测定;对于纯有机试剂样品,阿贝尔闭口杯法和宾斯基-马丁闭口杯法测得的闪点结果呈现较好的线性关系。 相似文献
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为了在双盘式磁力耦合器设计阶段分析振动噪声特性,优化双盘式磁力耦合器设计,提出了一种利用模态叠加原理来分析其振动噪声的方法。双盘式磁力耦合器具有高转矩密度与高效率等优势,因此逐渐发展成为煤矿机械柔性传动装置。由于双盘式磁力耦合内部的转子磁场非正弦分布以及涡电流谐波等因素影响,双盘式磁力耦合器输出转矩中不可避免的存在波动。若根据计算得出的双盘式磁力耦合器的电磁振动噪声特点,在设计时选取振动噪声小的参数进行优化组合,可在实际中降低其电磁振动及噪声,有利于减少制造成本。本文结合双盘式磁力耦合器的结构特征,提出了一种模态叠加响应法计算电磁振动噪声,建立了其电磁径向力的解析模型,并在多物理场耦合作用下分析主要电磁径向力波在工作频率内的谐波响应,最后在额定功率为55 kW双盘式磁力耦合器实验台上进行试验验证。基于麦克斯韦张量法,建立了双盘式磁力耦合器的径向电磁力解析模型,并得出0阶与10阶电磁径向力波是产生振动噪声的最主要原因;利用多物理场耦合分析法进行谐波响应NVH特性分析,结果显示0阶力波的振动加速度与形变量均大于10阶力波的振动加速度与形变量,因此双盘式磁力耦合器的电磁振动主要来源于0阶力波;在额定功率为55 kW,最高转速为1 500 r/min的双盘式磁力耦合器实验台进行振动测试,试验结果显示在1 500 r/min时,试验得出的最大振动峰值及频率约为35 m/s^2和4 950 Hz,与有限元仿真结果的误差对应为6.3%和1.1%;而当变频电机的输入转速依次增大时,振动加速度的理论值、仿真值与试验值的曲线形态较为接近,误差较小;噪声估计值与实测值的最大误差仅为8.9%,基本验证了本文所提出模态叠加法的正确性。 相似文献
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Sirshendu Guha 《American Institute of Chemical Engineers》2022,68(3):e17505
In continuation to my previous work (Guha S. AIChE J. 2013;59(4):1390-1399), in this work, effects of ionic migration are evaluated for disk region of a rotating ring disk electrode system by numerically solving complex differential equations, developed for mass transfer along with kinetic complication in presence of ionic migration under limiting current condition. The system for simulation is 0.01 M Fe2(SO4)3 solution with H2SO4 as supporting electrolyte. Simulation cases are presence and absence of ionic migration with kinetic complication (oxidation of Fe2+ to Fe3+ under O2 pressure). Results show that concentration boundary layer thickness of reactant Fe3+ reduces appreciably and steady-state disk current reduces substantially in presence of migration. Simulated steady-state disk current in absence of migration case agrees well with published data. Results indicate higher Fe2+ concentration in presence of migration and thereby higher rate of oxidation of Fe2+ to Fe3+ at all rate constant values. 相似文献
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The increased concentration of CO2 due to continuous breathing and no discharge of human beings in the manned closed space, like spacecraft and submarines, can be a threat to health and safety. Effective removal of low concentration CO2 from the manned closed space is essential to meet the requirements of long-term space or deep-sea exploration, which is an international frontier and trend. Ionic liquids (ILs), as a widespread and green solvent, already showed its excellent performance on CO2 capture and absorption, indicating its potential application in low concentration CO2 capture. In this review, we first summarized the current methods and strategies for direct capture from low concentration CO2 in both the atmosphere and manned closed spaces. Then, the multi-scale simulation methods of CO2 capture by ionic liquids are described in detail, including screening ionic liquids by COSMO-RS methods, capture mechanism by density functional theory and molecular dynamics simulation, and absorption process by computational fluid dynamics simulation. Lastly, some typical IL-based green technologies for low concentration CO2 capture, such as functionalized ILs, co-solvent systems with ILs, and supported materials based on ILs, are introduced, and analyzed the subtle possibility in manned closed spaces. Finally, we look forward to the technology and development of low concentration CO2 capture, which can meet the needs of human survival in closed space and proposed that supported materials with ionic liquids have great advantages and infinite possibilities in the vital area. 相似文献
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为满足土地质量调查的需求,实现土壤中多组分的同时消解及准确测定,提高大批量样品的分析效率,建立了土壤样品经高压密闭消解后,采用电感耦合等离子体原子发射光谱法(ICP-AES)测定K2O、Na2O、CaO、MgO、Ba、Mn、Cu、Zn的方法。通过对消解体系、酸用量、消解温度等方面的考察,确定最佳实验条件;并对待测液中共存元素Al、Fe的干扰进行探讨,两者均不干扰测定。各组分校准曲线线性相关系数均大于0.999;检出限为0.01~10μg/g。实验方法用于测定土壤标准样品GBW07385、GBW07386、GBW07388中K2O、Na2O、CaO、MgO、Ba、Mn、Cu、Zn,测定结果的相对标准偏差(RSD,n=12)为1.1%~4.3%,相对误差RE为-4.0%~4.6%。采用实验方法对土壤实际样品中K2O、Na2O、CaO、MgO、Ba、Mn、Cu、Zn进行测定,结果的RSD(n=6)为1.2%~4.6%;并与地矿行业标准方法DZ/T 0279.2—2016测定结果进行比对,测得结果基本一致。 相似文献
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介绍了湖州南方物流有限公司中转仓储及输送工程项目的建设背景、建设条件,以及线路规划、主要技术方案,该项目是国内采用长距离越野曲线带式输送机系统运输熟料距离最长的绿色环保工程。项目以电力驱动运输替代汽车运输,日输送量达4.5~5万吨。采用密闭廊道输送,粉尘排放量低,噪声<50dB,日均减少汽车运输3000辆次,年节约燃油2000余吨,减少了尾气排放,缓解了沿线的交通拥堵,实现了良好的经济效益和社会效益。 相似文献