全文获取类型
收费全文 | 136225篇 |
免费 | 8198篇 |
国内免费 | 2364篇 |
专业分类
电工技术 | 3460篇 |
技术理论 | 1篇 |
综合类 | 2645篇 |
化学工业 | 24250篇 |
金属工艺 | 5738篇 |
机械仪表 | 7885篇 |
建筑科学 | 5053篇 |
矿业工程 | 953篇 |
能源动力 | 5060篇 |
轻工业 | 10604篇 |
水利工程 | 1324篇 |
石油天然气 | 1603篇 |
武器工业 | 293篇 |
无线电 | 21419篇 |
一般工业技术 | 24208篇 |
冶金工业 | 12648篇 |
原子能技术 | 1673篇 |
自动化技术 | 17970篇 |
出版年
2024年 | 168篇 |
2023年 | 1337篇 |
2022年 | 1622篇 |
2021年 | 3800篇 |
2020年 | 2878篇 |
2019年 | 2757篇 |
2018年 | 3525篇 |
2017年 | 3480篇 |
2016年 | 4077篇 |
2015年 | 3634篇 |
2014年 | 5375篇 |
2013年 | 8613篇 |
2012年 | 8244篇 |
2011年 | 9648篇 |
2010年 | 7754篇 |
2009年 | 7984篇 |
2008年 | 7594篇 |
2007年 | 6656篇 |
2006年 | 6023篇 |
2005年 | 5161篇 |
2004年 | 4577篇 |
2003年 | 4324篇 |
2002年 | 4136篇 |
2001年 | 3527篇 |
2000年 | 2899篇 |
1999年 | 2692篇 |
1998年 | 4559篇 |
1997年 | 3024篇 |
1996年 | 2519篇 |
1995年 | 1945篇 |
1994年 | 1562篇 |
1993年 | 1428篇 |
1992年 | 1051篇 |
1991年 | 962篇 |
1990年 | 863篇 |
1989年 | 831篇 |
1988年 | 653篇 |
1987年 | 581篇 |
1986年 | 501篇 |
1985年 | 466篇 |
1984年 | 408篇 |
1983年 | 309篇 |
1982年 | 264篇 |
1981年 | 249篇 |
1980年 | 247篇 |
1979年 | 198篇 |
1978年 | 180篇 |
1977年 | 249篇 |
1976年 | 345篇 |
1975年 | 159篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Ji Hye Yang Sae Kwang Ku IL Je Cho Je Hyeon Lee Chang-Su Na Sung Hwan Ki 《International journal of molecular sciences》2021,22(4)
Hepatic fibrosis occurs when liver tissue becomes scarred from repetitive liver injury and inflammatory responses; it can progress to cirrhosis and eventually to hepatocellular carcinoma. Previously, we reported that neoagarooligosaccharides (NAOs), produced by the hydrolysis of agar by β-agarases, have hepatoprotective effects against acetaminophen overdose-induced acute liver injury. However, the effect of NAOs on chronic liver injury, including hepatic fibrosis, has not yet been elucidated. Therefore, we examined whether NAOs protect against fibrogenesis in vitro and in vivo. NAOs ameliorated PAI-1, α-SMA, CTGF and fibronectin protein expression and decreased mRNA levels of fibrogenic genes in TGF-β-treated LX-2 cells. Furthermore, downstream of TGF-β, the Smad signaling pathway was inhibited by NAOs in LX-2 cells. Treatment with NAOs diminished the severity of hepatic injury, as evidenced by reduction in serum alanine aminotransferase and aspartate aminotransferase levels, in carbon tetrachloride (CCl4)-induced liver fibrosis mouse models. Moreover, NAOs markedly blocked histopathological changes and collagen accumulation, as shown by H&E and Sirius red staining, respectively. Finally, NAOs antagonized the CCl4-induced upregulation of the protein and mRNA levels of fibrogenic genes in the liver. In conclusion, our findings suggest that NAOs may be a promising candidate for the prevention and treatment of chronic liver injury via inhibition of the TGF-β/Smad signaling pathway. 相似文献
2.
3.
4.
Peiying Wang Juanli Zhao Yun Fan Wei Zhang Yuanyuan Cui Liangmiao Zhang Bin Liu Hongqiang Nian Yiran Li 《Ceramics International》2021,47(11):15023-15029
In this work, the composition-dependent point defect types and formation energies of RE2Hf2O7 (RE = La, Ce, Pr, Nd, Pm, Sm, Eu and Gd) as well as the oxygen diffusion behavior are systematically investigated by first-principles calculations. The possible defect reactions and dominant defect complexes under stoichiometric and non-stoichiometric conditions are revealed. It is found that O Frenkel pairs are the predominant defect in stoichiometric pyrochlore hafnates. Hf-RE cation anti-site defects, accompanied by RE vacancies and/or oxygen interstitials, are stable in the non-stoichiometric case of HfO2 excess. On the other hand, RE-Hf anti-site defects together with oxygen vacancies and/or RE interstitials are preferable in the case of RE2O3 excess. The energy barriers for the migration along the VO48f - VO48f pathway of pyrochlore hafnates were calculated to be between 0.81 eV and 0.89 eV. Based on these results, a defect engineering strategy is proposed and the pyrochlore hafnates investigated here are predicted to exhibit potential oxygen ionic conductivity. 相似文献
5.
Chenchen Zhou Jia Man Haibo Yu He Xia Luming Man Bin Qi Jianfeng Li 《Ceramics International》2021,47(8):10866-10872
Ceramic microparticles have great potentials in various fields such as materials engineering, biotechnology, microelectromechanical systems, etc. Morphology of the microparticle performs an important role on their application. To date, it remains difficult to find an effective and controllable way for fabricating nonspherical ceramic microparticles with 3D features. This work demonstrates a method that combines UV light lithography and single emulsion opaque-droplet-templated microfluidic molding to prepare the crescent-shaped ceramic microparticles. By tailoring the intensity of UV light and flow rate of fluid, the shapes of microparticles are accordingly tuned. Therefore, varieties of crescent-shaped microparticles and their variations have been fabricated. After sintering, the crescent-shaped alumina ceramic microparticles were obtained. Benefitting from the light absorption and scattering behavior of most ceramic nanoparticles, this system can serve as a general platform to produce crescent-shaped microparticles made from different materials, and hold great potentials for applications in microrobotics, structural materials in MEMS, and biotechnology. 相似文献
6.
Shin Hansub Sim Sungyong Kwon Hyukyoon Hwang Sangheum Lee Younho 《International Journal of Information Security》2022,21(1):25-36
International Journal of Information Security - This paper deals with a well-known problem in the area of the smudge attacks: when a user draws a pattern to unlock the pattern lock on a smartphone... 相似文献
7.
Hong Sae Jin Park Nam Il Hwang Dae Keun Yi Tae Gyu Eum Hyang Lan 《Food science and biotechnology》2022,31(6):669-679
Food Science and Biotechnology - Various hilling materials (rice hulls, pine sawdust, and perlite) were compared to produce sprout vegetables using beach silvertop (Glehnia littoralis Fr. Schm. ex... 相似文献
8.
Zhang Nan Zhao Man Liu Guangfa Wang Jiaoyang Chen Yunzhi Zhang Zhengjian 《Journal of Materials Science》2022,57(19):8687-8700
Journal of Materials Science - A green modification method for effectively enhancing toughness of PLA was established. Herein, alkaline lignin (LG) was firstly alkylated with dodecane, and then... 相似文献
9.
Ping-Chi Hsu Jia-Ying Jhong Li-Ping Huang Kuo-Hsin Lee Hsin-Pao Chen Yue-Leon Guo 《International journal of molecular sciences》2021,22(8)
Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in the manufacture of polyvinylchloride plastics and has been associated with concerns regarding male reproductive toxicity. In this study, we hypothesized that maternal exposure to DEHP induces transgenerational inheritance of adult-onset adverse reproductive outcomes through the male germline in the F1, F2, and F3 generations of male offspring. Pregnant rats were treated with 5 or 500 mg of DEHP/kg/day through gavage from gestation day 0 to birth. The offspring body weight, anogenital distance (AGD), anogenital index (AGI), sperm count, motility, and DNA fragmentation index (DFI) were measured for all generations. Methyl-CpG binding domain sequencing was performed to analyze sperm DNA methylation status in the F3. DEHP exposure at 500 mg/kg affected AGD, AGI, sperm count, mean DFI, and %DFI in the F1; AGD, sperm count, and mean DFI in the F2; and AGD, AGI, mean DFI, and %DFI in the F3. DEHP exposure at 5 mg/kg affected AGD, AGI, sperm count, and %DFI in the F1; sperm count in the F2; and AGD and AGI in F3. Compared with the control group, 15 and 45 differentially hypermethylated genes were identified in the groups administered 5 mg/kg and 500 mg/kg DEHP, respectively. Moreover, 130 and 6 differentially hypomethylated genes were observed in the groups administered 5 mg/kg and 500 mg/kg DEHP. Overall, these results demonstrated that prenatal exposure to DEHP caused transgenerational epigenetic effects, which may explain the observed phenotypic changes in the male reproductive system. 相似文献
10.