Optimistic Personality and Psychosocial Well-Being During Treatment Predict Psychosocial Well-Being Among Long-Term Survivors of Breast Cancer.

In considering well-being among survivors of life-threatening illnesses such as breast cancer, 2 important questions are whether there is continuity between initial adjustment and longer term adjustment and what role personality plays in long-term adjustment. In this research, a sample of 163 early stage breast cancer patients whose psychosocial adjustment was first assessed during the year after surgery completed the same measures 5-13 years after surgery. Initial reports of well-being were relatively strong predictors of follow-up well-being on the same measures. Initial optimism and marital status also predicted follow-up adjustment, even controlling for earlier adjustment, which exerted a substantial unique effect in multivariate analyses. In contrast, initial medical variables played virtually no predictive role. There is substantial continuity of subjective well-being across many years among survivors of breast cancer, rooted partly in personality and social connection. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Expanded Polystyrene Foam Formed from Polystyrene Beads Coated with a Nanocrystalline SiO2 Film and the Analysis of Its Moisture Adsorption and Resistance to Mechanical Stress

Conventional expanded polystyrene can absorb moisture, which significantly degrades its properties. In the present study, it was demonstrated that SiO₂ can be deposited on polystyrene beads before pre-expansion and molding steps. Under the applied test conditions, expanded polystyrene with nanocrystalline SiO₂ additives had approximately 10% lower moisture adsorption and an 8.4% better resistance to deformation. Expanded polystyrene analysis suggested that the observed improvements were caused by the hydrophobic nature of nanocrystalline SiO₂ and, even more importantly, because SiO₂ acted as an amalgamation catalyst and significantly increased adhesion between the expanded polystyrene beads during the expanded polystyrene molding process.     

The diagnostic utility of HASTE MRI in the evaluation of acute cholecystitis. Half-Fourier acquisition single-shot turbo SE

OBJECTIVE: To investigate the incidence of complications in the use of assisted reproductive technology in the management of infertile couples. DESIGN: Retrospective study. SETTING: The Egyptian IVF & ET Center, Maadi, Cairo, Egypt. PATIENT(S): Two thousand nine hundred twenty-four patients underwent IVF-ET or intracytoplasmic sperm injection (ICSI) in 3,500 cycles. INTERVENTION(S): IVF-ET, ICSI, ejaculate sperm, epididymal sperm aspiration, and testicular sperm extraction. MAIN OUTCOME MEASURE(S): Complications of the procedure and complications of pregnancy in 702 patients. RESULT(S): Fifteen hundred ovum pickups for IVF-ET and 2,000 ovum pickups for ICSI were performed. Clinical pregnancy occurred in 1,078 patients (30.8%). Four groups of complications were identified. Complications of the procedure occurred in 291 patients (8.3%). Complications of pregnancy included ectopic pregnancy in 1.9%, heterotopic pregnancy in 0.2%. abortion in 20.6%, multiple pregnancy in 28%, pregnancy-induced hypertension in 10%, preterm labor in 21.5%, low birth weight in 30.5%, and intrauterine death in 2%. Coincidental complications occurred in five patients (0.15%). Other complications that were difficult to measure included psychological breakdown and socioeconomic problems. CONCLUSION(S): Assisted reproductive technology is effective for the management of infertility and has an acceptable incidence of complications. Complications rarely endanger the life of the patient. When this line of treatment is offered, the indications should be definitive. Patients should be monitored properly and measures should be taken to minimize the incidence of complications.     

Search for unstable DNA in schizophrenia families with evidence for genetic anticipation

Evidence for genetic anticipation has recently become an important subject of research in clinical psychiatric genetics. Renewed interest in anticipation was evoked by molecular genetic findings of a novel type of mutation termed "unstable DNA." The unstable DNA model can be construed as the "best fit" for schizophrenia twin and family epidemiological data. We have performed a large-scale Southern blot hybridization, asymmetrical PCR-based, and repeat expansion-detection screening for (CAG)n/(CTG)n and (CCG)n/(CGG)n expansions in eastern Canadian schizophrenia multiplex families demonstrating genetic anticipation. There were no differences in (CAG)n/(CTG)n and (CCG)n/(CGG)n pattern distribution either between affected and unaffected individuals or across generations. Our findings do not support the hypothesis that large (CAG)n/(CTG)n or (CCG)n/(CGG)n expansions are the major etiologic factor in schizophrenia. A separate set of experiments directed to the analysis of small (30-130 trinucleotides), Huntington disease-type expansions in individual genes is required in order to fully exclude the presence of (CAG)n/(CTG)n- or (CCG)n/(CGG)n-type unstable mutation.     

Socially aware microcloud service overlay optimization in community networks

Community networks are a growing network cooperation effort by citizens to build and maintain Internet infrastructure in regions that are not available. Adding that, to bring cloud services to community networks (CNs), microclouds were started as an edge cloud computing model where members cooperate using resources. Therefore, enhancing routing for services in CNs is an attractive paradigm that benefits the infrastructure. The problem is the growing consumption of resources for disseminating messages in the CN environment. This is because the services that build their overlay networks are oblivious to the underlying workload patterns that arise from social cooperation in CNs. In this paper, we propose Select in Community Networks (SELECTinCN), which enhances the overlay creation for pub/sub systems over peer-to-peer (P2P) networks. Moreover, SELECTinCN includes social information based on cooperation within CNs by exploiting the social aspects of the community of practice. Our work organizes the peers in a ring topology and provides an adaptive P2P connection establishment algorithm, where each peer identifies the number of connections needed based on the social structure and user availability. This allows us to propagate messages using a reduced number of hops, thus providing an efficient heuristic to an NP-hard problem that maps the workload graph to the structured P2P overlays resulting in a number of messages close to the theoretical minimum. Experiments show that, by using social network information, SELECTinCN reduces the number of relay nodes by up to 89% using the community of practice information versus the state-of-the-art pub/sub notification systems given as baseline.     

Fuzzynet: Ringless routing in a ring-like structured overlay

Many structured overlay networks rely on a ring invariant as a core network connectivity element. The responsibility ranges of the participating peers and navigability principles (greedy routing) heavily depend on the ring structure. For correctness guarantees, each node needs to eagerly maintain its immediate neighboring links - the ring invariant. However, the ring maintenance is an expensive task and it may not even be possible to maintain the ring invariant continuously under high churn, particularly as the network size grows. Furthermore, routing anomalies in the network, peers behind firewalls and Network Address Translators (NATs) create non-transitivity effects, which inevitably lead to the violation of the ring invariant. We argue that reliance on the ring structure is a serious impediment for real life deployment and scalability of structured overlays. In this paper we propose an overlay called Fuzzynet, which does not rely on the ring invariant, yet has all the functionalities of structured overlays. Fuzzynet takes the idea of lazy overlay maintenance further by dropping any explicit connectivity and data maintenance requirement, relying merely on the actions performed when new Fuzzynet peers join the network. We show that with sufficient amount of neighbors (O(log N), comparable to traditional structured over-lays), even under high churn, data can be retrieved in Fuzzynet w.h.p. We validate our novel design principles by simulations as well as PlanetLab experiments and compare them with ring based overlays.     

A miniaturized flow reaction chamber for use in combination with QCM-D sensing

A miniaturized flow chamber for quartz crystal microbalance with dissipation monitoring (QCM-D) has been developed. The main purpose was to reduce the total liquid sample consumption during an experiment, but also to gain advantages with respect to kinetics and mass transport by reducing the boundary diffusion layer. The bottom of the flow chamber is a QCM-D sensor surface, on which a polydimethylsiloxane spacer ring, fabricated onto a poly(methyl methacrylate) lid, is placed symmetrically around the QCM-D electrode (diameter ~10 mm). The spacer ring defines the inner chamber height (typically 40–50 μm) and provides sealing. Through the lid, there are inlet and outlet channels. The typical chamber volume is in the range of 2.5–3.5 μl (with a 10 μl dead volume). In flow mode, we have operated the cell at flow rates of 6–50 μl/min, i.e., volume turnovers of 2–17 per min. As a model system, to test the microcell, the formation of supported phospholipid bilayers on a SiO₂ surface was studied. For comparison, the same process was studied in a commercially available QCM-D equipment with significantly larger total volume (by a factor of 20). The decrease in effective sample consumption to produce a bilayer on the sensor surface in the chamber was approximately proportional to the decrease in chamber volume. Smaller volume also reduced the liquid exchange time. Potential improvements of the chamber include further optimization of the flow profile and, in addition, further miniaturization by decreasing the chamber height and the sensor radius.