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Paclitaxel(PTX) is an effective anticancer drug with poor solubility in water.Recently,much effort has been devoted into alternative formulations of PTX for improving its aqueous solubility.In this study,PTX and poly(L-lactic acid)(PLLA) were co-precipitated by a supercritical antisolvent(SAS) process using dichloromethane(DCM) and the mixtures of DCM/ethanol(EtOH) or DCM/dimethyl sulfoxide(DMSO) as the solvent,with super-critical carbon dioxide as the antisolvent.The effects of solvent,solvent ratio,temperature,pressure,polymer con-centration and solution flow rate on particle morphology,mass median diameter(Dp50) and PTX loading were in-vestigated using single-factor method.The particle samples were characterized using X-ray diffraction(XRD),scanning electron microscopy(SEM),laser diffraction particle size analyzer and high pressure liquid chromatogra-phy(HPLC).XRD results indicate that the micronized PTX is dispersed into the PLLA matrix in an amorphous form.SEM indicates that the solvent and the solvent ratio have great effect on the particle morphologies,and particle morphology is good at the volume ratio of DCM/EtOH of 50/50.For the mixed DCM/EtOH solvent,Dp50 increases with the increase of the temperature,pressure,PLLA concentration and solution flow rate,and PTX loading in-creases with pressure.Suitable operating conditions for the experimental system are as follows:DCM/EtOH 50/50(by volume),35 ℃,10-12 MPa,PLLA concentration of 5 g·L-1 and solution flow rate of 0.5 ml·min-1. 相似文献
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本文测定了金塑复合管的阻力性能,并与同一规格的镀锌管、聚丙烯管进行比较,对实验结果进行分析,结果表明,金塑复合管在同一流量和同一R_e下,其阻力性能优于镀锌管和聚丙烯管,是一种性能优良的流体输送管路,符合环境保护对民用水管的要求。 相似文献
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废话水中有机污染物高级氧化过程的降解 总被引:6,自引:0,他引:6
讨论了废朱中有机污染物O3/H2O2高级氧化过程的降解及其反应机理,探讨了有机污染物高级氧化过程降解的控制机制。 相似文献
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焙烧温度对氧化铝膜孔性能的影响 总被引:4,自引:0,他引:4
利用TG-DTA、BET法分析研究了热处理过程的膜孔径分布、孔径大小及膜的比表面积、比孔容随焙烧温度的变化趋势,并用XRD研究了氧化铝膜的膜内晶体的晶面取向,用TEM、SEM观察用溶胶─凝胶法制备的氧化铝膜的表面及截面形貌.发现构成氧化铝膜的微晶的择优取向度决定着膜孔径分布的均匀性,焙烧温度越高,膜微晶的择优取向度越大,膜的孔径分布越窄,但孔径增大.膜的比表面积、比孔容在400℃有一最大值,400℃是合适的膜催化、反应用膜的焙烧温度,这时膜比表面积、比孔容和孔隙率分别为283m2/g、0.338mL/g和53%.700℃是分离用膜的合适焙烧温度,这时膜比表面积、比孔容和孔隙率分别为202m2/g、0.203mL/g和45%.700℃时膜的最大孔径为5nm;孔径为1~1.25nm的孔占孔体积的70%以上. 相似文献
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