排序方式: 共有54条查询结果,搜索用时 78 毫秒
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固体药物晶型定量分析方法 总被引:1,自引:0,他引:1
药物的不同晶型会影响药效及其生物利用度,药物晶型及其含量的确定是确保药物产品的最终质量并指导药物制剂开发和生产的主要问题。针对近年来固体药物多晶型定量分析领域的研究进展进行了综述,并结合实例对3类定量分析方法(X射线粉末衍射(XRPD)法、光谱法、热分析法)的特点、适用场合进行了分析评述。目前XRPD法仍是鉴别多晶型的最主要手段,但晶体的择优取向与试样制备过程均会影响定量分析的准确度。各种光谱法对于晶体结构差异的敏感性高,且快速、无损检测,试样处理简单,在晶型定量分析中的应用具有潜力。热分析法对试样具有不可逆损害,但由于其准确度相对较高且操作方便,将来仍会得到广泛应用。 相似文献
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过程分析技术(PAT)因其具有"可以实时测量体系中各种参数变化来实现过程开发、优化、设计、分析和调控"的优点,而被广泛应用于工业生产和过程监测中。针对近年来PAT技术在工业结晶领域的应用,在对几种常用PAT技术的工作原理进行介绍的基础上,重点阐述了过程拉曼光谱(Raman)、衰减全反射傅里叶变换红外光谱(ATR-FTIR)、聚光束反射测量仪(FBRM)和粒子影像测量系统(PVM)在工业结晶过程中多晶型溶解度的测量、多晶型成核以及多晶型转晶方面的应用。上述PAT技术在结晶过程中的应用,有助于进一步了解结晶过程机理,进而有助于指导工业结晶过程的开发、优化、设计和放大。 相似文献
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熔融结晶及其耦合技术研究的进展 总被引:1,自引:0,他引:1
介绍逐步冻凝熔融结晶过程和悬浮熔融结晶过程以及各自特点,综述了近年来新型熔融结晶技术与设备的应用研究进展;着重介绍了耦合技术在熔融结晶过程中的应用研究动态;最后展望了熔融结晶技术与设备的发展趋势与方向。 相似文献
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论述了溶剂气浮分离技术研究现状,对所涉及的工艺和设备等关键问题进行了重点论述,展望了利用溶剂气浮法分离有机物稀溶液的工业化应用前景及研究重点. 相似文献
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The possibility of multiplicity in an isothermal continuous mixed suspension-mixed product removal crystallizer is explored using the bifurcation theory.A process involving agglomeration controlled precipitation is considered in which secondary nucleation occurs simultaneously with primary nucleation.The determinant equations for the existence of multiple steady states are developed and the multiplicity boundaries dependent on the physical and kinetic properties and operational parameters of the process are obtained by resolving these determinant equations.The number of steady states in the precipitator for various multiplicity regions is determined and the linear stability of these steady states is analyzed by using the Routh criterion. 相似文献
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Experimental densities, viscosities and heat capacities at different temperatures were presented over the entire range of mole fraction for the binary mixture of p-xylene and acetic acid. Density values were used in the determination of excess molar volumes, VE. At the same time, the excess viscosity and excess molar heat capacities were calculated. The values of V^E, η^E and cE/p were fitted to the Redlich-Kister equation. Good agreements were observed. The excess molar volumes are positive with a large maximum value located in the central concentrationrange. The excess viscosity has an opposite trend to the excess molar volume V^E. η^E values are negative over the entire range of the mixture. The cure of dependence of c E/p on concentration has a special shape. The molecularinteraction between v-xvlene and acetic acid is discussed. 相似文献
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1-环丙基-7-氯-6-(1-哌嗪基)-4-氧-1,4-二氢-3-喹啉羧酸盐酸盐为环丙沙星合成中主要的杂质之一,研究其物化性质对于改善环丙沙星的结晶分离提纯具有重要意义。本文研究了1-环丙基-7-氯-6-(1-哌嗪基)-4-氧-1,4-二氢-3-喹啉羧酸盐酸盐的熔化,分解特性,溶解度与离子强度,温度和pH值的关系,并测定了该物质的离解常数,估算了该物质在水溶液中的活度积。 相似文献
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