Congenital atrophic plaque

OBJECTIVE: To determine the distribution and severity of arterial lesions of intracranial and extracranial arteries in stroke patients in Chinese. METHODS: We studied 120 consecutive autopsy cases including 100 cases of stroke (50-80 years) and 20 cases of cancer as controls (50-80 years). Medium intracranial arteries and their primary branches, small intracerebral arteries, arterioles and extracranial carotid arteries (from 16 cases only) were examined with light microscopy. RESULTS: The stroke patients had significantly lower mean LA-VA ratios of the medium sized intracranial arteries and their primary branches, small intracerebral arteries and arterioles than the controls (P < 0.001). The stroke patients had higher mean VW-VR ratios of these arteries than the controls (P < 0.001). Atherosclerotic narrowing of the medium sized intracranial arteries and their primary branch were more severe than those of the extracranial caotid arteries. Moreover, the proximal portion of the primary branch arteries was much more severe than that of extracranial caotid arteries (P < 0.01, P < 0.05) in the stroke patients. CONCLUSION: Stroke patients had atherosclerotic lesions of the intracranial medium sized arteries and their primary branches and sclerotic lesions of the small intracerebral arteries and arterioles. These pathological changes resulted in thickening arterial walls and narrowing arterial lumens.     

A self-aligned gate GaAs MESFET with p-pocket layers forhigh-efficiency linear power amplifiers

This paper describes a newly developed GaAs metal semiconductor field-effect transistor (MESFET)-termed p-pocket MESFET-for use as a linear power amplifier in personal handy-phone systems. Conventional buried p-layer technology, the primary technology for microwave GaAs power MESFET's, has a drawback of low power efficiency for linear power applications. The low power efficiency of the buried p-layer MESFET is ascribed to the I-V kink which is caused by holes collected in the buried p-layer under the channel. In order to overcome this problem, we have developed the self-aligned gate p-pocket MESFET which incorporates p-layers not under the channel but under the source and drain regions. This new MESFET exhibited high transconductance and uniform threshold voltage. The problematic I-V kink was successfully removed and an improved power efficiency of 48% was achieved under bias conditions, which resulted in adjacent channel leakage power at 600-kHz offset as low as -59 dBc for 1.9-GHz π/4-shift QPSK modulated input     

Chemical Modification of Phage-Displayed Helix-Loop-Helix Peptides to Construct Kinase-Focused Libraries

Conformationally constrained peptides hold promise as molecular tools in chemical biology and as a new modality in drug discovery. The construction and screening of a target-focused library could be a promising approach for the generation of de novo ligands or inhibitors against target proteins. Here, we have prepared a protein kinase-focused library by chemically modifying helix-loop-helix (HLH) peptides displayed on phage and subsequently tethered to adenosine. The library was screened against aurora kinase A (AurA). The selected HLH peptide Bip - 3 retained the α-helical structure and bound to AurA with a K_D value of 13.7 μM. Bip - 3 and the adenosine-tethered peptide Bip - 3 - Adc provided IC₅₀ values of 103 μM and 7.7 μM, respectively, suggesting that Bip - 3 - Adc bivalently inhibited AurA. In addition, the selectivity of Bip - 3 - Adc to several protein kinases was tested, and was highest against AurA. These results demonstrate that chemical modification can enable the construction of a kinase-focused library of phage-displayed HLH peptides.     

β核磁共振和β核四极共振谱仪

为了开展核物理、粒子物理和凝聚态物理方面的研究 ,在中国原子能科学研究院建成了 1台 β核磁共振及 β核四极共振谱仪。利用该谱仪精确测量了12 B的极化度和12 B基态磁矩 ,所测量的12 B在Cu中的极化度为 1 1 4%± 0 6% ,12 B磁矩 μ =1 0 0 0 2± 0 0 0 2 8nm。实验应用证实该谱仪性能可靠。     

A Quasi-ARMAX approach to modelling of non-linear systems

This paper proposes a class of quasi-ARMAX models for non-linear systems. Similar to ordinary non-linear ARMAX models, the quasi-ARMAX models are flexible black-box models, but they have various linearity properties similar to those of linear ARMAX models. A modelling scheme is introduced to construct models consisting of two parts: a macro-part and a kernel-part. By using Taylor expansion and other mathematical transformation techniques, it is first constructed as a class of quasi-ARMAX interfaces (macro-parts) that have various linearity properties but contain some complicated coefficients. MIMO neurofuzzy models (kernel-parts) are then introduced to represent the complicated coefficients. It is shown that the proposed quasi-ARMAX models have both good approximation ability and some easy-to-use properties. The proposed models have been successfully applied to prediction, fault detection and adaptive control of non-linear systems.     

Criteria for versatile GaN MOVPE tool:high growth rate GaN by atmospheric pressure growth

Growth rate has a direct impact on the productivity of nitride LED production.Atmospheric pressure growth of GaN with a growth rate as high as 10μm/h and also Al_0.1Ga_0.9N growth of 1μm/h by using 4 inch by 11 production scale MOVPE are described.XRD of（002） and（102） direction was 200 arcsec and 250 arcsec, respectively.Impact of the growth rate on productivity is discussed.     

Effects of PbTiO 3 Seed Layer on the Characteristics of RF-Sputtered Pb(Zr 0.5 ,Ti 0.5 )O 3 Thin Films

The effects of seed layers on the characteristics of rf-sputtered lead zirconium titanate thin films were investigated. Prior to sputtering, PbTiO 3 seed layers (100 nm) were deposited onto the Pt/Ti/Si and Pt/Si substrates by sol-gel (spin coating) processing method. Structure-property relation was studied as functions of substrate temperature and sputtering conditions. Special efforts were given in optimizing the deposition parameters to prepare the films in the perovskite phase without post deposition annealing. Dielectric constant and loss tangent of the films were in the range 800-950 and 0.04 -0.06, respectively. Remanent polarization and coercive field were 23.1 w C/cm 2 and 75kV/cm, respectively, for the films without PbTiO 3 seed layer, where as the corresponding quantities for in situ -deposited perovskite Pb(Zr, Ti)O 3 films on PbTiO 3 seed layer were 28 w C/cm 2 and 65 kV/cm, respectively.     

Oxygen release behavior of metastable tetragonal t′meta-(Ce0.5Zr0.5)2 phases prepared by reduction and successive oxidation of t′ phase

Tetragonal CaF₂-related-type t′-/Ce_0.5Zr_0.5)O₂ phase was reduced at 773 K ≤ T_red. ≤ 1073 K to prepare precursors with various oxygen compositions: Ce₂Zr₂O_712d /0.111 < δ < 0.379). Metastable tetragonal t^′_meta-(Ce_0.5Zr_0.5)O₂ phases were prepared by oxidizing in O₂ at 873 K the precursors, and subjected to evolved oxygen gas analysis by heating the samples at a constant rate. When the precursor was prepared at T_red: ? 773 K; i.e. δ ? 0:379; the oxygen release behavior of the tetragonal phase agreed approximately with that of the t^′. For δ < 0.29, distinct features of the t^′_meta-(Ce_0.5Zr_0.5)O₂ appeared in the XRD results and Raman spectra. The temperature exhibiting the maximum release rate of oxygen from the t^′_meta became lower with decreasing the d value. It could be concluded that the thermodynamic behavior of the t^′_meta is related closely to the precursor composition and becomes more unstable with decrease in the δ value. The t^′ and t^′_meta phases with disordered arrangement of Ce and Zr ions may belong to the same space group; nevertheless, difference in the random arrays of the Ce and Zr ions was suggested on the basis of the present experimental results.     

Synthesis of charge transporting block copolymers containing 2,7-dimethoxycarbazole units for light emitting device

The block copolymers consisting of 2,7-dimethoxycarbazole- and oxadiazole-containing segments as hole and electron transporting units, respectively, were synthesized by NMRP manner. OLED devices were fabricated using block copolymer, random copolymer, and polymer blend for matrix of the emitting layer with Ir(ppy)₃ as a phosphorescent dopant in order to investigate morphological effect on the performance. From the finding that the block copolymer system overwhelmed the others in EQE, we assumed that a morphology with dimethoxycarbazole units assembled to the surface of PEDOT:PSS played a considerable role for effective recombination of charges as well as sufficient charge injection into the emitting layer.