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Sawarot Phetsuk Robert Molloy Kanarat Nalampang Puttinan Meepowpan Paul D Topham Brian J Tighe Winita Punyodom 《Polymer International》2020,69(3):248-256
Understanding the underlying role of microstructural design in polymers allows for the manipulation and control of properties for a wide range of specific applications. As such, this work focuses on the study of microstructure–property relationships in l‐ lactide/?‐caprolactone (LL/CL) copolymers. One‐step and two‐step bulk ring‐opening polymerization (ROP) procedures were employed to synthesize LL/CL copolymers of various compositions and chain microstructures. In the one‐step procedure, LL and CL were simultaneously copolymerized to yield P(LL‐stat‐CL) statistical copolymers. In the two‐step procedure, poly(l‐ lactide) (PLL) and poly(?‐caprolactone) (PCL) prepolymers were synthesized in the first step before CL and LL respectively were added in the second step to yield P[LL‐b‐(CL‐stat‐LL)‐b‐LL] and P[CL‐b‐(LL‐stat‐CL)‐b‐CL] block copolymers as the final products. The findings reveal that, in addition to the copolymerization procedure employed, the length and type of the prepolymer play important roles in determining the chain microstructure and thereby the overall properties of the final copolymer. Moreover, control over the degree of crystallinity and the type of crystalline domains, which is controlled during the polymer chemistry process, heavily influences the physical and mechanical properties of the final polymer. In summary, this work describes an interesting approach to the microstructural design of biodegradable copolymers of LL and CL for potential use in biomedical applications. © 2019 Society of Chemical Industry 相似文献
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Nayyatip S Thaichana P Buayairaksa M Tuntiwechapikul W Meepowpan P Nuntasaen N Pompimon W 《International journal of molecular sciences》2012,13(4):5010-5018
A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC(50) values of 1.68 and 1.32 μM, respectively. 相似文献
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Wijitra Meelua Robert Molloy Puttinan Meepowpan Winita Punyodom 《Journal of Polymer Research》2012,19(2):9799
Four titanium(IV) alkoxides, namely: Ti(IV) n-propoxide (1), Ti(IV) n-butoxide (2), Ti(IV) tert-butoxide (3), and Ti(IV) 2-ethylhexoxide (4), have been used as initiators in the bulk ring-opening polymerization (ROP) of ε-caprolactone (ε-CL). The influence of the alkoxide group on the course of the ROP of ε-CL was investigated by means of 1H-NMR and differential scanning calorimetry (DSC). The 1H-NMR spectra confirmed that the ROP reaction of ε-CL proceeded via the widely accepted coordination-insertion mechanism for each of the four initiators. Isoconversional methods
have been used to evaluate non-isothermal DSC data via the equations of Friedman, Kissinger-Akahira-Sunose (KAS) and Ozawa-Flynn-Wall
(OFW). The kinetic studies showed that the polymerization rate for the four initiators (1-4) was in the order of 1 > 2 ≈ 4 > 3. The lowest activation energies (40–47, 42–44, and 49–52 kJ/mol for the Friedman, KAS and OFW methods respectively) were
found in the polymerizations using Ti(IV) n-propoxide (1), while the highest activation energies (84–107, 77–87, and 80–91 kJ/mol for the Friedman, KAS and OFW methods respectively)
were obtained using Ti(IV) tert-butoxide (3). Differences in the rates of polymerization and the activation energies amongst the four initiators appeared to be governed
mainly by the different degrees of steric hindrance in the initiator structure. These results represent important findings
regarding the steric influence of the alkoxide groups on the kinetics of the ROP of ε-CL initiated by titanium(IV) alkoxides. 相似文献
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Boontharika Thapsukhon Napaphat Thadavirul Pitt Supaphol Puttinan Meepowpan Robert Molloy Winita Punyodom 《应用聚合物科学杂志》2013,130(6):4357-4366
The main objective of this work has been to study the effects of copolymer microstructure, both chemical and physical, on the microporosity, in vitro hydrolytic degradability and biocompatibility of electrospun poly(l ‐lactide‐co‐ε‐caprolactone), PLC, copolymer tubes for potential use as absorbable nerve guides. PLC copolymers with L : C compositions of 50 : 50 and 67 : 33 mol % were synthesized via the ring‐opening copolymerization of l ‐lactide (L) and ε‐caprolactone (C) at 120°C for 72 h using stannous octoate (tin(II) 2‐ethylhexanoate) and n‐hexanol as the initiating system. Electrospinning was carried out from solution in a dichloromethane/dimethylformamide (7 : 3 v/v) mixed solvent at room temperature. The in vitro hydrolytic degradation of the electrospun PLC tubes was studied in phosphate buffer saline over a period of 36 weeks. The microporous tubes were found to be gradually degradable by a simple hydrolysis mechanism leading to random chain scission. At the end of the degradation period, the % weight retentions of the PLC 50 : 50 and 67 : 33 tubes were 15.6% and 70.2%, respectively. Pore stability during storage as well as cell attachment and proliferation of mouse fibroblast cells (L929) showed the greater potential of the PLC 67 : 33 tubes for use as temporary scaffolds in reconstructive nerve surgery. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 4357–4366, 2013 相似文献
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