Current immunosensors have an insufficient number of binding sites for the recognition of biomolecules, which leads to false positive or negative results. In this research, a facile, cost‐effective, disposable, and highly selective electrochemical immunosensing platform is developed based on cationic polyelectrolyte polyallylamine (PAAMI) anchored laser‐ablated graphene (LAG). Here, for the first time, PAAMI is introduced to stabilize LAG flakes, while retaining the intrinsic thermal and electronic properties of the substrate by noncovalent π–π interaction and electrostatic physical absorption. The sensing platform offers a suitable number of anchoring sites for the immobilized antibodies by providing ? NH2 functional groups. The proper grafting of PAAMI is confirmed through X‐ray photoelectron spectroscopy and Raman spectroscopy. The immunosensing platform is applied to detect immunoglobulin (IgG) biomarkers as a proof of concept. Under optimized conditions, the sensing platform exhibits a linear range of 0.012–15 and 15–352 ng mL?1 with a limit of detection of 6 pg mL?1 for IgG detection with high selectivity. Based on the analysis, the developed immunosensing platform can be used for point‐of‐care detection of IgG in clinical diagnostic centers. Furthermore, the developed strategy is well suited for the detection of other cancer biomarkers after immobilizing the relevant antibodies. 相似文献
This work demonstrates a means of automatic transformation from planar electronic devices to desirable 3D forms. The method uses a spatially designed thermoplastic framework created via extrusion shear printing of acrylonitrile–butadiene–styrene (ABS) on a stress‐free ABS film, which can be laminated to a membrane‐type electronic device layer. Thermal annealing above the glass transition temperature allows stress relaxation in the printed polymer chains, resulting in an overall shape transformation of the framework. In addition, the significant reduction in the Young's modulus and the ability of the polymer chains to reflow in the rubbery state release the stress concentration in the electronic device layer, which can be positioned outside the neutral mechanical plane. Electrical analyses and mechanical simulations of a membrane‐type Au electrode and indium gallium zinc oxide transistor arrays before and after transformation confirm the versatility of this method for developing 3D electronic devices based on planar forms. 相似文献
Thermal tempering is an industrial process widely used to make soda lime silica (SLS) glass panels stronger and tougher. During the tempering process, the upper and bottom sides of the glass may experience different cooling rates, and thus, their properties could be different. This study characterized changes in surface composition and subsurface glass network structures as well as indentation and wear resistance properties of the air- and tin-sides of 6-mm-thick SLS window panels faced toward the upper and sliding roller sides during thermal tempering. The results showed that although the chemical and structural differences detected with X-ray photoelectron spectroscopy and specular reflection infrared spectroscopy are subtle, there are large differences in nanoindentation behaviors and mechanochemical wear properties of the SLS glass surface. The findings of this study provide further insights into the performance difference between the air- and tin-sides of the SLS glass panel treated with thermal tempering. 相似文献
Functional materials exhibiting magnetic and luminescent properties have been recognized as an emerging class of materials with great potential in advanced applications. Herein, properties of multifunctional ceramic composites consisting of two garnets, luminescent cerium-doped Y3Al5O12 (Ce:YAG) and magnetic Y3Fe5O12 (YIG), are reported. On increasing the sintering temperature, both the photoluminescence and saturation magnetization of the Ce:YAG-YIG composites decreased gradually because of the interdiffusion of trivalent ions such as Al3+ and Fe3+. At a constant sintering temperature of 1100?°C, the YIG contents in the composites increased, thereby causing their luminescent properties to degrade and the saturation magnetizations to increase. For application to electronics, Ce:YAG-YIG composite thin films were integrated on quartz substrates by sputtering the ceramic target. The composite thin films exhibited both magnetic and luminescent properties after annealing. These techniques facilitate the incorporation of multifunctional nanocomposites into various devices. 相似文献
Journal of Mechanical Science and Technology - Confocal fringe patterns of evaporating sessile drops have provided initial evidence of the presence of a sub-micron thin liquid film emanating from... 相似文献
The synthesis of large‐area TiS2 thin films is reported at temperatures as low as 500 °C using a scalable two‐step method of metal film deposition followed by sulfurization in an H2S gas furnace. It is demonstrated that the lowest‐achievable sulfurization temperature depends strongly on the oxygen background during sulfurization. This dependence arises because Ti? O bonds present a substantial kinetic and thermodynamic barrier to TiS2 formation. Lowering the sulfurization temperature is important to make smooth films, and to enable integration of TiS2 and related transition metal dichalcogenides—including metastable phases and alloys—into device technology. 相似文献
In the present study, improved two-parameter mixed models for large eddy simulations are proposed based on previous two-parameter mixed models of Salvetti and Banerjee [1] and Horiuti [2]. The subgrid-scale (SGS) stress in our models is decomposed into the modified Leonard stress, modified cross stress and modified SGS Reynolds stress terms. Although the modified Leonard stress term is explicitly calculated based on the scale-similarity, the modified cross stress term is built using an extension of the filtered Bardina model proposed by Horiuti [3] for better predictions of the interaction between resolved and unresolved scales (i.e., energy exchange). The modified SGS Reynolds stress is modeled by the dynamic Smagorinsky model or by a dynamic global model, leading to two unknown model coefficients for the modified cross stress and the modified SGS Reynolds stress terms. In order to demonstrate the reliability of the proposed SGS models, large eddy simulations of two types of flows (i.e., a fully developed turbulent channel flow and a transitional boundary layer flow) are performed. It is shown that the modified cross stress term makes an important contribution to the accurate predictions of such flows because the emergence of negative SGS dissipation (backward scatter) by the modified cross stress term decreases the excessive positive SGS dissipation (forward scatter). A direct comparison of the turbulent statistics with those from previous SGS models shows that the proposed SGS models result in better prediction performance both in transitional and turbulent flows.