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排序方式: 共有2410条查询结果,搜索用时 46 毫秒
1.
Hyun Sun Choi Yun Kee Jo Gwang-Noh Ahn Kye Il Joo Dong-Pyo Kim Hyung Joon Cha 《Advanced functional materials》2021,31(46):2104602
The esophagus is a tubular-shaped muscular organ where swallowed fluids and muscular contractions constitute a highly dynamic environment. The turbulent, coordinated processes that occur through the oropharyngeal conduit can often compromise targeted administration of therapeutic drugs to a lesion, significantly reducing therapeutic efficacy. Here, magnetically guidable drug vehicles capable of strongly adhering to target sites using a bioengineered mussel adhesive protein (MAP) to achieve localized delivery of therapeutic drugs against the hydrodynamic physiological conditions are proposed. A suite of highly uniform microparticles embedded with iron oxide (IO) nanoparticles (MAP@IO MPs) is microfluidically fabricated using the genipin-mediated covalent cross-linking of bioengineered MAP. The MAP@IO MPs are successfully targeted to a specific region and prolongedly retained in the tubular-structured passageway. In particular, orally administered MAP@IO MPs are effectively captured in the esophagus in vivo in a magnetically guidable manner. Moreover, doxorubicin (DOX)-loaded MAP@IO MPs exhibit a sustainable DOX release profile, effective anticancer therapeutic activity, and excellent biocompatibility. Thus, the magnetically guidable locomotion and robust underwater adhesive properties of the proteinaceous soft microbots can provide an intelligent modular approach for targeted locoregional therapeutics delivery to a specific lesion site in dynamic fluid-associated tubular organs such as the esophagus. 相似文献
2.
Effects of operating parameters in the thermal gradient chemical vapor infiltration of propane such as thermal gradient, diffusion, infiltrations time, and concentration of propane were studied by focusing on the visualizations of the intrinsic effects of these parameters. A uniform deposition in the preform was obtained with a gradually increasing temperature along the gas flow. The uniformity of deposition through the preform got improved with increasing deposition time. Results of numerical modeling estimated the experimental data very well when the pre-exponential factor of the overall rate of carbon deposition from propane reported by Vaidyaraman[1] was multiplied by 4. The average density of a preform increased by about 3 times from 0.38 to 1.15 g/cm3 after 60 hr deposition with a thermal gradient under the conditions of 3% propane in nitrogen and 840 to 900 ℃. 相似文献
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Scientometrics - This study describes the increase of research productivity of latecomer countries (latecomers) in the high-energy physics (HEP) community by research strategies based on a national... 相似文献
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Solongontuya Boldmaa Cheoi Kyung Joo Kim Mi-Hye 《The Journal of supercomputing》2021,77(9):10424-10440
The Journal of Supercomputing - In recent years, low back pain rehabilitation exercises have been widely performed for spine-related illnesses. To facilitate rehabilitation exercises, pose-based... 相似文献
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Wireless Networks - Recently optimal Carrier Sense Multiple Access (CSMA) scheduling schemes have attracted much attention in wireless networks due to their low complexity and provably optimal... 相似文献
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Metallurgical and Materials Transactions B - We developed a simulation model to predict inclusion transformation during the solidification of steel by linking the Ohnaka model with the FactSage... 相似文献
9.
Park Joo Hyun Lee Jong-Woo Um Jong-Seok Yook Juhye Kim Kwangki Lim Soon-Bum 《The Journal of supercomputing》2021,77(6):6381-6407
The Journal of Supercomputing - Although Digital Accessible Information System, an international digital talking book standard, is conducting active research on upper level education for people... 相似文献
10.
Magnetic Resonance Materials in Physics, Biology and Medicine - Our goal is to design and validate a simple apparatus for the safety assessments of magnetically induced torques by four active... 相似文献