A survey of dynamic parameter setting methods for nature-inspired swarm intelligence algorithms

Neural Computing and Applications - Parameter settings for nature-inspired optimization algorithms are essential for their effective performance. Evolutionary algorithms and swarm intelligence...     

Data-driven placemaking: Public space canopy design through multi-objective optimisation considering shading,structural and social performance

In the context of ongoing densification of cities and aging urban populations, public spaces are a crucial infrastructure to support the physical and mental wellbeing of urban residents. The design of public space furniture elements is often standardised, and not considered in relation to environmental conditions and mechanisms of social interaction. This article presents a digital workflow to generate site-specific designs for shaded public seating, considering the relationships of local public places to their surroundings. A strategy for customised and site-specific design is developed through the use of multiple software tools, employing evolutionary algorithms and multi-objective optimisation. The method is applied to a small public space canopy prototype installed within a public housing estate in Hong Kong, incorporating additional criteria to achieve a low-cost and light-weight structure. Through multiple stages of refinement and optimisation, a material, structural and social performance-driven outcome was achieved that creates a shaded space for public seating, people watching and social interaction. As part of a larger research agenda exploring architectural form-finding and environmental psychology, the project represents potential new applications in the emerging field of socially driven computational design.     

Novel Furin Inhibitors with Potent Anti‐infectious Activity

New peptidomimetic furin inhibitors with unnatural amino acid residues in the P3 position were synthesized. The most potent compound 4‐guanidinomethyl‐phenylacteyl‐Arg‐Tle‐Arg‐4‐amidinobenzylamide (MI‐1148) inhibits furin with a K_i value of 5.5 pM . The derivatives also strongly inhibit PC1/3, whereas PC2 is less affected. Selected inhibitors were tested in cell culture for antibacterial and antiviral activity against infectious agents known to be dependent on furin activity. A significant protective effect against anthrax and diphtheria toxin was observed in the presence of the furin inhibitors. Furthermore, the spread of the highly pathogenic H5N1 and H7N1 avian influenza viruses and propagation of canine distemper virus was strongly inhibited. Inhibitor MI‐1148 was crystallized in complex with human furin. Its N‐terminal guanidinomethyl group in the para position of the P5 phenyl ring occupies the same position as that found previously for a structurally related inhibitor containing this substitution in the meta position, thereby maintaining all of the important P5 interactions. Our results confirm that the inhibition of furin is a promising strategy for a short‐term treatment of acute infectious diseases.     

Strategic Planning for Employment Self-Containment in Metropolitan Sub-Regions

Metropolitan strategic plans often focus on strengthening local employment opportunities to address the congestion and commuting issues threatening city sustainability. The success of such strategies relies on a more equitable distribution of jobs between sub-regions and can be comparatively benchmarked through one of the three related measures of employment self-sufficiency, self-containment or jobs-housing balance. However, in practice, planning policy implementation to meet these targets seldom reduces automobile commuting. This paper investigates self-containment across a range of occupation and industry types to highlight large differences in commuting and employment patterns through a case study of Perth’s Northwest sub-region, Western Australia. Its findings suggest the application of current sub-regional policy and targets within Perth may reinforce the wage and skill disadvantage of outer metropolitan sub-regions over the inner core. It recommends a more nuanced understanding of these measures taking into account the complex dynamics of both employment opportunities and commuting patterns across sub-regions of a city.     

Farm-scale bio-power-to-methane: Comparative analyses of economic and environmental feasibility

Power-to-gas technologies are considered to be part of the future energy system, but their viability and applicability need to be assessed. Therefore, models for the viability of farm-scale bio-power-to-methane supply chains to produce green gas were analysed in terms of levelised cost of energy, energy efficiency and saving of greenhouse gas emission. In bio-power-to-methane, hydrogen from electrolysis driven by surplus renewable electricity and carbon dioxide from biogas are converted to methane by microbes in an ex situ trickle-bed reactor. Such bio-methanation could replace the current upgrading of biogas to green gas with membrane technology. Four scenarios were compared: a reference scenario without bio-methanation (A), bio-methanation (B), bio-methanation combined with membrane upgrading (C) and the latter with use of renewable energy only (all-green; D). The reference scenario (A) has the lowest costs for green gas production, but the bio-methanation scenarios (B-D) have higher energy efficiencies and environmental benefits. The higher costs of the bio-methanation scenarios are largely due to electrolysis, whereas the environmental benefits are due to the use of renewable electricity. Only the all-green scenario (D) meets the 2026 EU goal of 80% reduction of greenhouse gas emissions, but it would require a CO₂ price of 200 € t⁻¹ to achieve the levelised cost of energy of 65 €ct Nm⁻³ of the reference scenario. Inclusion of the intermittency of renewable energy in the scenarios substantially increases the costs. Further greening of the bio-methanation supply chain and how intermittency is best taken into account need further investigation.     

Stiff gelatin hydrogels can be photo-chemically synthesized from low viscous gelatin solutions using molecularly functionalized gelatin with a high degree of methacrylation

Gelatin is a very promising matrix material for in vitro cell culture and tissue engineering, e.g. due to its native RGD content. For the generation of medical soft tissue implants chemical modification of gelatin improves the mechanical properties of gelatin hydrogels and the viscous behavior of gelatin solutions for liquid handling. We present a systematic study on the influence of high degrees of methacrylation on the properties of gelatin solutions and photo-chemically crosslinked hydrogels. Changes from shear thinning to shear thickening behavior of gelatin solutions were observed depending on mass fraction and degree of methacrylation. Degrees of swelling of crosslinked hydrogels ranged from 194 to 770?% and storage moduli G′ from 368 to 5?kPa, comparable to various natural tissues including several types of cartilage. Crosslinked gels proofed to be cytocompatible according to extract testings based on DIN ISO 10933-5 and in contact with porcine chondrocytes.     

Design and implementation of multiaxial force sensing gripper fingers

This paper focuses on the integration of elementary force sensors into the fingers of parallel grippers. The theory of the approach of integrating three sensor elements into a gripper finger is described and the results of the practical evaluations are given. Strain gauges are used as elementary sensor elements. Two different design approaches are evaluated. The first one uses H-shaped cut-outs to weaken the structure at designated areas. The measurement accuracy of this system is compared with a second approach without cut-outs, which is easier to manufacture. Finite element analysis is used in both approaches to simulate the behaviour and to determine the best locations for strain gauge application. The performances of both design concepts are experimentally evaluated. It can be seen that the results of the finite-element analysis are correct and that a satisfactory decoupling of the basic sensors can be achieved using a physical or mathematical approach. Both prototypes are able to measure the gripping force with sufficient accuracy.