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排序方式: 共有1500条查询结果,搜索用时 265 毫秒
1.
Kyle J. Sommers Brian S. Bentley Dr. Robert G. Carden Savannah J. Post Ryan A. Allen Renee C. Kontos Jacob W. Black Prof. William M. Wuest Prof. Kevin P. C. Minbiole 《ChemMedChem》2021,16(3):467-471
Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs. 相似文献
2.
Daylon Black Ryan Harper Patrick Ward Jacob Davlin Omar Bentancourt Donald Plumlee Jim Browning 《International Journal of Applied Ceramic Technology》2020,17(5):2393-2406
A low temperature co-fired ceramic (LTCC) material system has been used to develop a protype field emission cathode structure for use in an experimental magnetron oscillator. The structure is designed for used with 30 gated field emission array (GFEA) die electrically connected through silver metal traces and electrical vias. To approximate a cylinder, the cathode structure (48 mm long and 13.7 mm in diameter) is comprised of 10 faceted plates which cover the GFEA dies. Slits in the facet plates allow electron injection. The GFEA die (3 mm × 8 mm) are placed in axial columns of 3 and spaced azimuthally around a cylindrical support structure in a staggered configuration resulting in 10 azimuthal locations. LTCC manufacturing techniques were developed in order to fabricate the newly designed cathode with seven layers wrapped to form the cylinder with electrical traces and vias. Two different cathode wrapping techniques and two different via filling techniques were studied and compared. Two different facet plate manufacturing techniques were studied. Finally, four different support stand configurations for firing the cylindrical structure were also compared with a square post stand having the best circularity and linearity measurements of the fired structure. 相似文献
3.
Dr. Mengjun Xue Prof. Roy A. Black Caitlin E. Cornell Prof. Gary P. Drobny Prof. Sarah L. Keller 《Chembiochem : a European journal of chemical biology》2020,21(19):2764-2767
A major challenge in understanding how biological cells arose on the early Earth is explaining how RNA and membranes originally colocalized. We propose that the building blocks of RNA (nucleobases and ribose) bound to self-assembled prebiotic membranes. We have previously demonstrated that the bases bind to membranes composed of a prebiotic fatty acid, but evidence for the binding of sugars has remained a technical challenge. Here, we used pulsed-field gradient NMR spectroscopy to demonstrate that ribose and other sugars bind to membranes of decanoic acid. Moreover, the binding of some bases is strongly enhanced when they are linked to ribose to form a nucleoside or – with the addition of phosphate – a nucleotide. This enhanced binding could have played a role in the molecular evolution leading to the production of RNA. 相似文献
4.
Aika Davis P. Barry Ryan Jordan A. Cohen Debra Harris Marilyn Black 《Indoor air》2021,31(5):1473-1483
Upholstered furniture is often manufactured with polyurethane foam (PUF) containing flame retardants (FRs) to prevent the risk of a fire and/or to meet flammability regulations, however, exposure to certain FRs and other chemicals have been linked to adverse health effects. This study developed a new methodology for evaluating volatile organic compound (VOC) and FR exposures to users of upholstered furniture by simulating use of a chair in a controlled exposure chamber and assessing the health significance of measured chemical exposure. Chairs with different fire-resistant technologies were evaluated for VOC and FR exposures via inhalation, ingestion, and dermal contact exposure routes. Data show that VOC exposure levels are lower than threshold levels defined by the US and global indoor air criteria. Brominated FRs were not detected from the studied chairs. The organophosphate FRs added to PUF were released into the surrounding air (0.4 ng/m3) and as dust (16 ng/m2). Exposure modeling showed that adults are exposed to FRs released from upholstered furniture mostly by dermal contact and children are exposed via dermal and ingestion exposure. Children are most susceptible to FR exposure/dose (2 times higher average daily dose than adults) due to their frequent hand to mouth contact. 相似文献
5.
Jennifer Simmons Paul Ziemkiewicz D. Courtney Black 《Mine Water and the Environment》2002,21(2):91-99
Steel slag from the Waylite steel-making plant in Bethlehem, Pennsylvania was leached with acidic mine drainage (AMD) of a known quality using an established laboratory procedure. Leaching continued for 60 cycles and leachates were collected after each cycle. Results indicated that the slag was very effective at neutralizing acidity. The AMD/slag leachates contained higher average concentrations of Ba, V, Mn, Cr, As, Ag, and Se and lower average concentrations of Sb, Fe, Zn, Be, Cd, Tl, Ni, Al, Cu, and Pb than the untreated AMD. Based on these tests, slag leach beds were constructed at the abandoned McCarty mine site in Preston County, West Virginia. The leach beds were constructed as slag check dams below limestone-lined settling basins. Acid water was captured in limestone channels and directed into basins to leach through the slag dams and discharge into a tributary of Beaver Creek. Since installation in October 2000, the system has been consistently producing net alkaline, pH 9 water. The treated water is still net alkaline and has a neutral pH after it encounters several other acidic seeps downstream. 相似文献
6.
Kyrsten E. Black Jennifer A.H. Lowe Michael F. Billett Malcolm S. Cresser 《Water research》1993,27(7)
River water has been sampled under baseflow conditions in both summer and winter at c. 250-m intervals along the length of each of seven rivers in northeast Scotland, and the nitrate contents have been determined. The resultant data have been examined in the context of the nitrogen saturation hypothesis. Capacity of the catchment soils to retain nitrate was generally minimal in winter. Although biological uptake of nitrate was evident in summer, in the upper part of each catchment substantial nitrate leaching still occurred. The phenomenon was most marked in water draining from hill peats, except where these were conspicuously waterlogged. The results are discussed in the context of possible nitrogen saturation effects on upper catchment slopes. 相似文献
7.
S. Weichenthal G. Mallach R. Kulka A. Black A. Wheeler H. You M. St‐Jean R. Kwiatkowski D. Sharp 《Indoor air》2013,23(3):175-184
Few studies have examined indoor air quality in First Nations communities and its impact on cardiorespiratory health. To address this need, we conducted a crossover study on a First Nations reserve in Manitoba, Canada, including 37 residents in 20 homes. Each home received an electrostatic air filter and a placebo filter for 1 week in random order, and lung function, blood pressure, and endothelial function measures were collected at the beginning and end of each week. Indoor air pollutants were monitored throughout the study period. Indoor PM2.5 decreased substantially during air filter weeks relative to placebo (mean difference: 37 μg/m3, 95% CI: 10, 64) but remained approximately five times greater than outdoor concentrations owing to a high prevalence of indoor smoking. On average, air filter use was associated with a 217‐ml (95% CI: 23, 410) increase in forced expiratory volume in 1 s, a 7.9‐mm Hg (95% CI: ?17, 0.82) decrease in systolic blood pressure, and a 4.5‐mm Hg (95% CI: ?11, 2.4) decrease in diastolic blood pressure. Consistent inverse associations were also observed between indoor PM2.5 and lung function. In general, our findings suggest that reducing indoor PM2.5 may contribute to improved lung function in First Nations communities. 相似文献
8.
9.
Robert B. Black 《Journal of the American Planning Association. American Planning Association》2013,79(3):28-35
Abstract A SYMPOSIUM OF CURRENT PLANNING THEORY: Planning for America , By GEORGE B. GALLOWAY AND ASSOCIATES. Henry Holt and Co., New York; 713 pages, price $3. A TEXTBOOK ON SUBDIVISION: Subdivision Regulations: An Analysis of Land Subdivision Control Practices. By HAROLD W. LAUTNER. Public Administration Service; 346 pages, price $3.75. EMPLOYMENT IN THE REGIONAL DEVELOPMENT OF RESOURCES: Development of Resources and Stabilization of Employment in the United States. By THE NATIONAL RESOURCES PLANNING BOARD; 409 pages, price $1.20. 相似文献
10.
Marilyn Domas White 《国际互联网参考资料服务季刊》2013,18(1):79-80
ABSTRACT Included in this bibliography are Internet sites pertaining to the United States Congress. Covered are the official sites from Congress and its supporting agencies. In addition, there are unofficial sites that contain Congress-related information. These include general Web sites of interest groups, document collections sites, general Congress-related sites, voter information and e-mail sites, as well as sites providing access to newsgroups, newsletters, and bulletin boards. There is a great deal of information on Congress to be found on the Internet. With public Internet stations popping up in libraries, and the increase in personal Internet accounts, the Internet can help technology meet democracy. And with the ever-increasing trend by government agencies, including the Government Printing Office, to move toward electronic information, it will be important to know where to find the information. Hopefully, this bibliography will help you locate the information you are seeking on Congress. 相似文献