ResearchGate and Google Scholar: how much do they differ in publications,citations and different metrics and why?

ResearchGate has emerged as a popular professional network for scientists and researchers in a very short span. Similar to Google Scholar, the ResearchGate indexing uses an automatic crawling algorithm that extracts bibliographic data, citations, and other information about scholarly articles from various sources. However, it has been observed that the two platforms often show different publication and citation data for the same institutions, journals, and authors. While several previous studies analysed different aspects of ResearchGate and Google Scholar, the quantum of differences in publications, citations, and metrics between the two and the probable reasons for the same are not explored much. This article, therefore, attempts to bridge this research gap by analysing and measuring the differences in publications, citations, and different metrics of the two platforms for a large data set of highly cited authors. The results indicate that there are significantly high differences in publications and citations for the same authors captured by the two platforms, with Google Scholar having higher counts for a vast majority of the cases. The different metrics computed by the two platforms also differ in their values, showing different degrees of correlation. The coverage policy, indexing errors, author attribution mechanism, and strategy to deal with predatory publishing are found to be the main probable reasons for the differences in the two platforms.

     

Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs

Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the Bunyaviridae family that causes high rates of mortality and morbidity in humans and ruminant animals. Previous studies indicated that DEAD-box helicase 17 (DDX17) restricts RVFV replication by recognizing two primary non-coding RNAs in the S-segment of the genome: the intergenic region (IGR) and 5′ non-coding region (NCR). However, we lack molecular insights into the direct binding of DDX17 with RVFV non-coding RNAs and information on the unwinding of both non-coding RNAs by DDX17. Therefore, we performed an extensive biophysical analysis of the DDX17 helicase domain (DDX17_135–555) and RVFV non-coding RNAs, IGR and 5’ NCR. The homogeneity studies using analytical ultracentrifugation indicated that DDX17_135–555, IGR, and 5’ NCR are pure. Next, we performed small-angle X-ray scattering (SAXS) experiments, which suggested that DDX17 and both RNAs are homogenous as well. SAXS analysis also demonstrated that DDX17 is globular to an extent, whereas the RNAs adopt an extended conformation in solution. Subsequently, microscale thermophoresis (MST) experiments were performed to investigate the direct binding of DDX17 to the non-coding RNAs. The MST experiments demonstrated that DDX17 binds with the IGR and 5’ NCR with a dissociation constant of 5.77 ± 0.15 µM and 9.85 ± 0.11 µM, respectively. As DDX17_135–555 is an RNA helicase, we next determined if it could unwind IGR and NCR. We developed a helicase assay using MST and fluorescently-labeled oligos, which suggested DDX17_135–555 can unwind both RNAs. Overall, our study provides direct evidence of DDX17_135–555 interacting with and unwinding RVFV non-coding regions.     

CO2 Hydrogenation over Ru-NPs Supported Amine-Functionalized SBA-15 Catalyst: Structure–Reactivity Relationship Study

Catalysis Letters - We gave an effective protocol to support Ru NPs on amine-functionalized SBA-15 mesoporous silica to catalyze the CO2 hydrogenation reaction. The amine groups present in the...     

The Structures of Gd(III) Chelates Conjugated at the Periphery of 3-(1’-Hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH) Have a Significant Impact on the Imaging and Therapy of Cancer

3-(1’-Hexyloxyethyl)-3-devinyl-pyropheophorbide-a (HPPH or Photochlor), a tumor-avid chlorophyll-a derivative currently undergoing human clinical trials, was conjugated at various peripheral positions (position-17 or 20) of HPPH with either Gd(III)-aminobenzyl-DTPA (Gd(III) DTPA) or Gd(III)-aminoethylamido-DOTA (Gd(III) DOTA). The corresponding conjugates were evaluated for in vitro PDT efficacy, T₁, T₂ relaxivities, in vivo fluorescence, and MR imaging under similar treatment parameters. Among these analogs, the water-soluble Gd(III)-aminoethylamido-DOTA linked at position-17 of HPPH, i. e., HPPH-17-Gd(III) DOTA, demonstrated strong potential for tumor imaging by both MR and fluorescence, while maintaining the PDT efficacy in BALB/c mice bearing Colon-26 tumors (7/10 mice were tumor free on day 60). In contrast to Gd(III) DTPA (Magnevist) and Gd(III) DOTA (Dotarem), the HPPH-Gd(III) DOTA retains in the tumor for a long period of time (24 to 48 h) and provides an option of fluorescence-guided cancer therapy. Thus, a single agent can be used for cancer-imaging and therapy. However, further detailed pharmacokinetic, pharmacodynamic, and toxicological studies of the conjugate are required before initiating Phase I human clinical trials.     

Muddling between science and engineering: an epistemic strategy for developing human factors and ergonomics as a hybrid discipline

Human Factors and Ergonomics (HFE) recognises itself as a design-driven, systemic and scientific discipline geared towards well-being and performance. Being a scientific discipline and design-oriented requires that the epistemic basis of science and design/engineering be fully comprehended. In interdisciplinary research where these two viewpoints meet, there are often dilemmas posed in terms of knowledge construction and labelling of activity. Therefore, this article scrutinises these two orientations and addresses the differences and commonalities, using case studies from engineering and psychological science (both constituents of HFE). Based on these insights, a way forward is suggested in terms of (1) a reflexive engagement with epistemic concepts and methods; (2) finding a conceptual space for balancing and bridging the science-engineering divide; (3) comprehending ‘design-thinking/design knowledge’ and not treating it as an application of science; (4) providing emphasis on problem formulation and practices of HFE focusing on developing them in systemic terms.     

The sociotechnical constitution of cognitive work analysis: roles,affordances and malfunctions

Analysis of everyday work practices in sociotechnical systems for eliciting design/intervention requirements involves appropriate work analysis frameworks. The current article provides an extension to one such framework — Cognitive Work Analysis (CWA) — by scrutinising its sociotechnical basis. CWA's forte depends on its ‘design for adaptation’, system related operations, and operators. In contrast, sociotechnical work systems require not only operators and adaptation, but also a significant emphasis on ‘users’ and ‘appropriation’. The current article extends CWA (based on Rasmussen's original concepts) for users; subsequently allowing for system flexibility and possibilities of ‘appropriation’ within acceptable boundaries of the system's correct functioning. To this end, the first phase of Work Domain Analysis is extended by adding a new layer to the abstraction hierarchy (AH), based on Rasmussen's original insights.     

A Pyropheophorbide Analogue Containing a Fused Methoxy Cyclohexenone Ring System Shows Promising Cancer-Imaging Ability

Herein we report the synthesis, photophysical properties, positron emission tomography (PET) imaging and photodynamic therapy (PDT) efficacy of methyl 3-(1′-m-iodobenzyloxy)ethyl-3-devinyl-verdin 4 (with or without the ¹²⁴I isotope). The PET imaging ability and ex vivo biodistribution of [¹²⁴I] 4 were compared with the well-studied methyl [3-(¹²⁴1′-m-iodobenzyloxy)ethyl]-3-devinyl-pyropheophorbide-a methyl ester (PET-ONCO or [¹²⁴I] 2 ) and [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) in BALB/c mice bearing colon-26 tumors. Whole-body PET images of [¹²⁴I] 4 containing a fused methoxy cyclohexenone ring system showed excellent tumor contrast with time (72>48>24 h post-injection). Ex vivo biodistribution results indicate that relative to the current clinical standard [¹⁸F]FDG and [¹²⁴I] 2 in 2 % ethanol formulation, [¹²⁴I] 4 , at the same radioactive dose (25 μCi per mouse), showed higher tumor uptake at 24 h post-injection and longer tumor retention. In biological environments, compound 4 showed lower fluorescence and lower singlet oxygen yield than 2 , which is possibly due to higher aggregation caused by the presence of a fused cyclohexenone ring system, resulting in limited in vitro/in vivo PDT efficacy. Therefore, the chlorophyll-a analogue [¹²⁴I] 4 provides easy access to a novel PET imaging agent (with no skin phototoxicity) to image cancer types—brain, renal carcinomas, pancreas—in which [¹⁸F]FDG shows limitations.     

Design and calibration of a laminar soil box suitable for a low-capacity shake table using free-field tests on Ganga sand

The present study concentrates on design, commissioning and calibration of a uniaxial laminar soil box suitable for use on a low base-shear capacity shake table available at IIT Kanpur, India. The box is designed to simulate the behavior of soil deposits subjected to earthquake motions, with minimal boundary effects due to reflection of waves at the boundary. The 1.1 m × 1.6 m × 0.765 m box is comprised of a series of individual lamina supported independently on multiple roller bearings guided through a guide channel. The outer frame connected to the guide rods is designed in such as way that it can transfer the self weight of each lamina out of the shake table. A series of free-field tests are carried out on dry Ganga sand sample to calibrate the box. Dynamic response parameters, such as acceleration, displacement, stress-strain behavior, strain-dependant modulus and damping ratio of the sand at various depth are investigated. Large strain and subsequent increased inelasticity is observed towards the top of the sand bed. The experimental results are further compared with equivalent-linear SHAKE analysis and nonlinear finite element ground response analysis of the free-field soil using OpenSees for assessing the performance of the laminar box.     

The impact of alphabet size on pattern complexity of maxmin-$$\omega$$ω cellular automata

Natural Computing - We present an analysis of an additive cellular automaton (CA) under asynchronous dynamics. The asynchronous scheme is maxmin-$$\omega$$, a deterministic system, introduced in...